Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"fibrosarcoma"”.
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Glucocorticosteroid modification of lymphocyte blastogenesis in fibrosarcoma-bearing mice
… the influence of glucocorticoids on immunity in fibrosarcoma-bearing mice. Effects of hydrocortisone-21-sodium succinate (HCS) on mitogen-induced lymphocyte proliferation were assessed. T cells from nontumor-bearing mice showed a 2-fold suppression of phytohemagglutinin (PHA) responsiveness with …
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Fibrosarcoma-induced Dysregulation of Interleukin (IL)-1β and IL-18 Activities and their Modulation by Paclitaxel
Cancer remains an elusive killer due, in part, to the suppression of normal immunologic antitumor responses. Normal host (NH) macrophage (Mϕ) populations have tumoricidal effects such as tumor antigen phagocytosis and presentation, and cytokine production. Tumor-infiltrating Mϕs may evade these …
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Pengaruh ekstrak etanol akar widuri (Calotropis gigantea L.) terhadap kadar IFN-y dan ekspresi caspase 3 pada fibrosarcoma mencit (Mus musculus L.)
… IFN-γ, Caspase 3 dan rata-rata berat badan pada fibrosarcoma mencit (Mus musculus L.) akibat induksi 7,12-Dimetilbenz(α) Antrasena (DMBA). Penelitian ini merupakan penelitian eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan 5 ulangan, masing-masing adalah kelompok Kontrol …
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Investigation of protein induction in vascular-targeted strategies.
… of vascular disrupting agent CA-4-P. Two mouse fibrosarcoma models (expressing VEGF120/ VEGF188 isoforms only) following treatment with the tubulin-binding tumour vascular disrupting agent, combretastatin A-4-phosphate (CA-4-P) have been studied. The gross haemorrhagic pharmacological response …
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Creg1 And Its Enhancement Of P16ink4a-Induced Senescence
… We confirmed this in osteosarcoma and fibrosarcoma cancer cell lines, similar to those seen in patients with Li-Fraumeni Syndrome. Because CREG1 was shown to interact with Rb pocket proteins in vitro, we tested whether growth suppression by CREG1 may depend on the phosphorylation status …
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A tumour suppressor role for the T-box transcription factor TBX3 in fibroblasts
… in a number of transformed fibroblast and fibrosarcoma cell lines of mesenchymal origin. Fibro sarcoma is an aggressive soft-tissue sarcoma derived from fibroblasts and, while it occurs very rarely, there are no targeted therapy approaches and survival rates remain low. More work is clearly …
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Implicación de las quiomicinas CCL2 CCL5 en modelos de dolor neoplásico experimental.
… en ratones inoculados con células tumorales de fibrosarcoma NCTC 2472. Este efecto se produce tanto a nivel periférico como espinal y se acompaña del aumento de la quimiocina CCL2. La mayor presencia espinal de CCL2 se relaciona con la activación de astroglía y microglía. También el bloqueo de …
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Migration of tumor cells and leukocytes in extracellular matrix : proteolytic and nonproteolytic strategies for overcoming tissue barriers
… RT-PCR. Protease activity by migrating HT-1080 fibrosarcoma cells resulting in collagenolysis in situ and generation of tube-like matrix defects was detected by three newly developed techniques:(i) quantitative FITC-release from FITC-labelled collagen, (ii) structural alteration of the pyhsical …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… demonstrate that CD9 expression promotes human fibrosarcoma cell invasion by upregulating matrixmetalloproteinase-9 expression. These effects were dependent upon an extracellular region of CD9 and involved the presence and activity of the epidermal growth factor receptor. In the vascular cell …
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Catalytic-Independent And Subtype-Specific Roles Of Fructose-1,6-Bisphosphatase 2 In Sarcoma Growth
… and tumor growth in liposarcoma and fibrosarcoma models in vitro and in vivo. In contrast, FBP2 appears to promote tumor growth in an autochthonous LSL-KrasG12D/+;Trp53fl/fl (KP) model of undifferentiated pleiomorphic sarcoma (UPS), reflecting human epidemiological data. Collectively, …
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The Effects of Biological Response Modification and Diet on the Immune Respose of Tumor-bearing mice
… (H238) cells in the thigh causing a visible fibrosarcoma within 1-2 weeks. Mice were fed either a diet low in protein (milk) and low in fat (Diet 1), or another diet low in protein (wheat) and high in fat (Diet 8). Spleen cells were collected for assays of cytotoxic T-lynphocyte (CTL) and …
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Pengaruh ekstrak etanol daun widuri terhadap gambaran histologis fibrosarkoma mencit (Mus musculus) jantan yang diinduksi 7,12- Dimetilbenz(A)antrasena (DMBA) secara In vivo
… have cytotoxic concerning cancer cell include fibrosarcoma. That actif substance can restrain mitocondria (cell organ energy producer) which is needed by cancer cell to develop. This research as a purpose to know influence ethanol extract of calotropis gigantea concerning histology image of …
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
… of MMP-9 transcription by IFN-beta in HT1080 fibrosarcoma cells. Using reporter assays with promoter deletion constructs we show that IFN-beta's inhibitory effects require a region of the promoter between -154 and -72, which contains an AP-1 binding site. Chromatin immunoprecipitation (ChIP) …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… to limit the progression of xenotransplanted fibrosarcoma and malignant glioma tumors and provided a survival advantage in nude mice. We also engineered NDV M based particles with nipah virus surface glycorporteins to target ephrin B receptors. NDV based nipah Virus BNPs (NiV-ndBNP) were …
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Cell-surface Tumoricidal Molecules and NF-kB in the Tumor-burdened Host
… FasL analysis was also extended to the MethKDE fibrosarcoma and I found that these tumor cells express high levels of FasL. Because past observations show increased TNF-a mRNA expression in TBH macrophages relative to NH macrophages, I hypothesized that NF-kB activation may be increased as well. …
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Effects of selenium and vitamin B-6 on growth of chemically- induced transplanted tumors in BALB/c inbred mice
Male weanling inbred, mice were inoculated with fibrosarcoma cells (hindquarter) originally produced by 2-methylcholanthrene. Before inoculation, mice were randomly divided into three groups of 24 and one of 12 (control). After a one week acclimation period, each group was fed a diet containing …
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Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… with spleen metastases; and one had soft palate fibrosarcoma. Treatment of all six dogs was associated with minimal side effects, was easy to perform, was associated with repair of bone lysis in cured dogs; improved the quality of life for dogs with partial responses; and extended overall …
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Gradients in Collagen Films: Effects of Mechanical and Chemical Properties on Directional Cell Response
… tested using human dermal fibroblasts (HDFs), fibrosarcoma cells (HT1080s) and rat Schwann cells (RSCs). HDFs showed an unfavourable response to high EDC/NHS crosslinking levels, but increased proliferation with increasing genipin crosslinking. The presence of IKVAV dendrimers enhanced RSC …
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The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-α
… lines dincluding the L929 and WEHI 164 murine fibrosarcoma cell lines. Very little is known about the mechanisms of TNFa action. However, recently, it has been theorized that TNFa has no activity of its own and that the receptor for TNFa on the cell surface, when properly triggered, activates …
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Biophysical characterization of KO513, a protein expressed in human invasive glioblastoma
… assay shows promising interactors of K0513 from fibrosarcoma cell line; future studies will identify the interactors using Liquid chromatography-mass spectrometry.
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