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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 308 for “"fibrils"”.
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Thermodynamic Characterisation of Amyloid Fibrils
… One such gap is the thermodynamics of amyloid fibrils and how clinical agents modify the stability of fibrils, either positively or negatively. Thus far there has been a focus on the kinetic stability of amyloid fibrils due to the development and availability of kinetic assays. Specifically, …
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Unzipping Amyloid Fibrils: How a Novel Calcium-Binding Protein, NUCB1, Prevents the Formation of Amyloid Fibrils
… sNUCB1 can effectively dissociate amyloid fibrils formed by both hIAPP and Aβ42. Interestingly, Ca<sup>2+</sup> disrupts this unique functional ability of sNUCB1. In order to circumvent this, we designed and purified a Ca<sup>2+</sup>-insentive mutant namely sNUCB1(tetramutant) that is …
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Ligands as Structural Probes for Amyloid Fibrils
[Restricted]
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Smart Nanomaterials from Repeat Proteins and Amyloid Fibrils
… for protein-based materials are amyloid fibrils and tandem repeat proteins. Amyloid fibrils are exceptionally strong, tough, highly-ordered structures that self-assemble from a wide range of simple building blocks. Meanwhile, tandem repeat proteins are a class of proteins that act as …
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Mechanical behavior of individual type I collagen fibrils
… information about the mechanics of collagen fibrils (50 - 500 nm diameter) that serve as mesoscale building blocks in tissues. In this dissertation research the mechanical behavior of dry individual reconstituted collagen fibrils with different diameters were investigated via monotonic tests …
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Time dependent mechanical behavior of mammalian collagen fibrils
Collagen fibrils, with dry diameters of the order of 100 nm, are the fundamental building blocks in connective mammalian tissues. While the mechanical behavior of tissues has been studied extensively and was shown to follow non-linear viscoelasticity, as similar quantitative understanding of the …
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Deformation mapping of fibronectin fibrils using digital image correlation
… deposited. Prior work has shown that fibronectin fibrils are one of the earliest ECM proteins to be assembled. Time lapse imaging techniques show that the deposition of fibronectin by osteoblasts is a highly dynamic process, in which the forming fibronectin fibril network is continually stretched, …
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Enhancement Of Ebola Virus Infection By Seminal Amyloid Fibrils
… influencing this phenomenon are known. Amyloid fibrils present in healthy individuals’ semen have been suggested to be a host factor that aids in sexual transmission of viruses including HIV-1. To understand if seminal amyloid fibrils increase infection by Ebola virus, a recombinant virus …
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Structural studies of amyloid fibrils using solid-state NMR
… NMR techniques and application to amyloid fibrils are presented. In addition, a new method of selective inversion based on chemical shift anisotropy is presented. An improved method for highly accurate distance measurement across parallel [beta]-sheets in amyloid fibrils has been developed. …
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Movement-induced orientation of collagen fibrils in cartilaginous tissues
Thesis (Sc. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1994.
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
<p>Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid …
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Solid-State Nuclear Magnetic Resonance Spectroscopy of Alpha-Synuclein Fibrils
… towards solving 3D structures of amyloid fibrils. Alpha-synuclein is a 140-residue protein that has been implicated in Parkinson's disease. Fibrils of alpha-synuclein are the primary fibrillar component of Lewy bodies, which are the pathological hallmark of the disease; however, the role …
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THE ROLE OF BACTERIAL AMYLOID FIBRILS IN ESCHERICHIA COLI COMPLEMENT RESISTANCE
Strains of Escherichia coli may exist as a beneficial human commensal or a pathogen capable of causing morbidity and mortality. Of the E. coli which causes human disease, many strains which cause bacteremia have been identified as possessing virulence factors which make them more resistant to the …
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Strain Estimation of Fibronectin Fibrils Using Two Dimensional Digital Image Correlation
… we could observe the assembly process from no fibrils to formation of a mature fibril network. Two Dimensional Digital Image Correlation (2D-DIC), a powerful optical computational tool, was used to quantify the tensile and compressive strains experienced by the assembling fibronectin fibrils …
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Whey and soy amyloid fibrils as a novel iron delivery nanosystem
Made available in DSpace on 2021-03-05T21:45:39Z (GMT). No. of bitstreams: 3 LOPEZBARRERA-DISSERTATION-2020.pdf: 4739947 bytes, checksum: 3a81506eaeeb66965bb5969148fe29a6 (MD5) LICENSE.txt: 4216 bytes, checksum: 2137c615d49ed126107fc5db0021ee66 (MD5) PROQUEST_LICENSE.txt: 4562 bytes, checksum: …
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Automated protein NMR data analysis and its application to a-synuclein fibrils
In principle, nuclear magnetic resonance (NMR) spectroscopy provides structural and conformational information with sub-Angstrom precision and the ability to measure dynamics with timescales ranging from femtoseconds to years, all with atomic specificity. However, due to the relatively low …
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Development of PET Radiotracers for Imaging Neurodegeneration: Targeting alpha-Synuclein Fibrils and TSPO
… applied as radiotracers for imaging α-synuclein fibrils (project 1), or TSPO (project 2) via PET. Over the course of project 1 a library of compounds was synthesised based upon structural modifications of a lead structure identified from the literature. These compounds then underwent screening …
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Structural Characterization of Plaque Seeded Amyloid-β Fibrils by Magic Angle Spinning NMR
Accumulation of plaques consisting of amyloid fibrils of the peptide amyloid-β (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). Aβ is prone to polymorphism and the structure of fibrils is sensitive to the conditions under which they are formed. The two dominant forms of Aβ are …
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