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Showing 1 to 20 of 123 for “"ferritin"”.
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Kininogen and Ferritin in Tumorigenesis
… inhibit angiogenesis both in vitro and in vivo. Ferritin is a 24-subunit iron-storage protein which is mostly located intracellularly. Small amounts of ferritin also exist in serum and are often elevated during inflammation and some malignancies. Previous studies have demonstrated that ferritin …
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Ferritin: Mechanistic Studies and Electron Transfer Properties
Ferritins are ubiquitous iron storage proteins in living systems. Although much is known about the iron deposition process in ferritin and a mechanism has been developed, several important issues still remain unknown. One lingering question is the less than stoichiometric quantities of hydrogen …
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Ferritin species and metabolism in striated muscle.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1976
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Atomic Force Microscope Conductivity Measurements of Single Ferritin Molecules
… measure the conductivity of single horse spleen ferritin (HoSF) and azotobacter vinelandii bacterial ferritin (AvBF) molecules deposited on flat gold surfaces. A 500 micron diameter gold ball was also used as a contact probe to measure the conductivity of a thin film of ferritin molecules. The …
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Elucidating the Ferritin-High Molecular Weight Kininogen Domain 5 Interaction
… effects to HK5. The HK5 domain also binds to ferritin, an iron storage protein, which can inhibit the antiangiogenic effects of HK5. How ferritin inhibits the antiangiogenic effects of HK5 remains an important question.
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COMPUTER APPLICATIONS IN QUANTITATIVE EPR SPECTROSCOPY OF METALLOPROTEINS (FERRITIN, APOFERRITIN, IRON)
… study of early iron binding in horse spleen apoferritin. Iron(II) was added to apoferritin followed by oxidation by a variety of methods. In all cases an iron(III) EPR signal was observed at g' = 4.3 which was attributed to mononuclear Fe(III) bound to the protein; this signal increased until …
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Cell free synthesis of ferritin using the Modified Reticulocyte Lysate System.
Thesis: M.S., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1978
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Stability Study of Engineered Ferritin Nano-vaccines by Combined Molecular simulation and Experiments
Ferritins are a type of protein that is present in almost all living things. They have a symmetric spherical shape with strong physical and chemical stabilities. Human heavy-chain ferritins (HFns) have an inner cavity of 12 nm and 24 identical subunits. Ferritins are known to be assembled and …
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Cloning and characterization of a novel ferritin from the marine diatom Pseudo-nitzschia multiseries
… biomass. Recently, gene sequences encoding ferritin, a nearly ubiquitous iron storage and detoxifying protein, have been identified in pennate diatoms such as Pseudo-nitzschia, but not in other Stramenopiles (which include centric diatoms, brown algae and some protist plant parasites) or …
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NANOTECHNOLOGICAL APPROACHES FOR CANCER DIAGNOSIS, TREATMENT AND MANAGEMENT: IMPLEMENTATION OF FERRITIN PROTEIN NANOPARTICLES FOR TUMOR TARGETING
… of a NPs based on recombinant heavy-chain ferritin nanocages (HFn). HFn nanocages represent a promising protein- based class of NPs for drug delivery widely investigated by virtue of (1) their natural tumor homing and limited accumulation in off-target organs which leads to reduced …
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Σχέση σιδήρου και φερριτίνης ορού μητέρας και νεογνού
Iron status, including haemoglobin, S-iron and S-ferritin was evaluated in 256 healthy mothers at parturition and in 256 of their term newborn infants. Mothers were divided in two groups. Group A included 188 mothers iron-supplemented and group Β 68 mothers non iron-supplemented in their pregnancy. …
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Metabolism of supplemental iron by hepatic parenchymal and sinusoidal cells of the neonatal pig
… mobilized from all three cell types. The role of ferritin in metabolism and storage of accumulated iron was investigated. An antiserum was prepared against porcine liver ferritin and the quantity of cellular ferritin was measured by immunoelectrophoresis. The amount of cellular iron associated …
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Elucidation Of The Functional Role Of Pcbp-The Cytosolic Iron Chaperone Protein Family, In Cellular Iron Homeostasis
<p> <i> Biological Role of Ferritin </i> - Iron is essential for life and often utilized as a cofactor in many proteins. In humans, iron accumulation causes cirrhosis, arthritis, cardiomyopathy and diabetes mellitus, and it is associated with increased risk of cancer and heart disease. In contrast, …
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Development and validation of quantitative methods for the analysis of clinical biomarkers of iron metabolism applying stable isotopes
… intracellularly, incorporated in the protein ferritin. However, a small fraction of this protein in the ng ml-1 range can be detected in serum. Serum ferritin concentration forms part of a series of biomarkers routinely determined in clinical laboratories to assess the iron status in patients. …
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Determining the Molecular Underpinnings of Iron Homeostasis in Human Cells
… excess iron in large proteinaceous cages called ferritin and, when available iron levels fall, they degrade these cages, liberating the stored iron for use. This thesis focuses on the molecular mechanisms underlying cellular iron sensing, as well as the molecular interactions supporting regulated …
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Effects of carbohydrates on iron metabolism in intestinal and liver cells
… and FOS&GOS effects on iron bioavailability with ferritin formation as a surrogate marker for iron uptake. Ferritin formation was also utilised to assess iron uptake in HepG2 cells. Expression of iron homeostasis proteins was analysed by Western Blot and Polymerase Chain Reaction (PCR) to explore …
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The rational structure-based design of a protein nanoparticle presenting a chimeric MenB antigen
… toward the rational design of a self-assembling ferritin nanoparticle system displaying a chimeric protein antigen to stimulate broad and efficacious immunogenicity against MenB.;This chimeric antigen, incorporating epitopes from the NadA3 and PorA MenB antigens seeks to confer broader MenB …
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