Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"essential function"”.
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Essential Function of Ghrelin in Chronic Starvation
… of octanoate to serine-3 of ghrelin, a step essential for making active ghrelin. In this study, we eliminated the Goat gene from mice to produce Goat –/– mice that lack octanoylated ghrelin. These mice were indistinguishable in weight from their wild-type (WT) littermates in when fed either a …
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Functions of The Trna Splicing Endonuclease and Other Adventures In Rna Processing
… has been studied for over three decades for its function in tRNA splicing. However, this enzyme has other functions that are just beginning to be characterized. Mutations in TSEN cause the neuronal disease pontocerebellar hypoplasia (PCH) that is characterized by atrophy of the cerebellum and …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… APLP1 and APLP2, which have overlapping functions, the normal function of APP is difficult to elucidate. Knockout of the entire APP gene family in mice results in lethality and developmental defects, indicating that the APP gene family has an essential function. The nematode …
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The Domains of The Catalytic Subunit of The Eukaryotic Rna Degrading Exosome, Rrp44P, Have Distinct Functions
… 5’ exoribonuclease complex that consists of ten essential subunits. In the cytoplasm, the exosome degrades mRNA in a general mRNA turnover pathway and in several mRNA surveillance pathways. In the nucleus, the exosome processes RNA precursors to form small, stable, mature RNA species, including …
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Biochemical and genetic analysis of a fission yeast ribonucleoprotein homologous to signal recognition particle
… the haploid yeast, demonstrating that the RNA is essential for cell viability. Since secretion is an essential function of the cell, this observation is consistent with its proposed role in this process.
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Design and optimization of a Formula SAE racecar chassis and suspension
… of hundreds of parts that all perform an essential function. This thesis examines the critical factors in designing and implementing a Formula SAE chassis from the ground up, with a focus on the performance and optimization of the vehicle as an entire system rather than a collection of …
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Location linked information
… on a handheld computer, the system provides two functions for its urban users: 1) the retrieval of information about their surroundings, and 2) the optional annotation of location for communal benefit. Having the ability to link physical location with arbitrary information is an essential …
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Determination of the Feasibility of Using Cell-Free DNA (cfDNA) in the Q-Clamp KRAS Codon Specific Mutation Test
… virus. The normal KRAS protein performs an essential function in normal tissue signaling and a mutation of a KRAS gene is an essential step in the development of many cancers. Q-Clamp® KRAS codon specific mutation test is an in vitro real-time qualitative PCR assay for the detection of …
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Obstacle detection for robot navigation using structured light
Obstacle detection is an essential function for autonomous mobile robots. Current autonomous systems are generally heavy, high-powered devices. Additionally, obstacle detection systems often employ active ranging sensors that exhibit poor angular resolution, thereby preventing vehicles from …
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Essential and Ubiquitous: The Inns of Eighteenth-Century British Fiction
… inimitable role the inn plays in society as a functional and temporary home for travelers, a local hub for regionally isolated communities, and a convening space for all of England, and thus they exploit the space for its utility. Since the space of the inn simultaneously resides outside the …
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Investigations into Why Human (but not mouse) KU70/80 is Essential Reveal a Role for Human KU70/80 in Ribosome Biogenesis
… in higher primates explains otherwise perplexing essential nature of this double-strand break (DSB) repair factor. We have ruled out telomere protection or DSB repair as the essential function ofKu70/80. Instead, unbiased genome-wide analyses pointed to a role in ribosome biogenesis. Human …
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Managing projects utilizing self-managed teams and managerial toolkits
Project Management is an essential function in most software companies today. With increasing complexity and inter connectivity between software projects, it is not surprising that managing such large scale development projects can be expensive and extremely time consuming for the sponsoring …
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BUILDING GRANTEE CAPACITY THROUGH AN INNOVATIVE-PROCESS-DRIVEN, PEOPLE-CENTERED-EVALUATION FRAMEWORK
Program evaluation is an essential function for grant-seeking organizations, yet many struggle with measuring the impact of their work. The form of program evaluation is also an ongoing challenge for funders. Many grant-seeking nonprofits possess limited internal capacity, and are consequently …
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Identifying the Economic Barriers to CLT Cost Estimation Among Building Construction Professionals
… that surveyed cost estimators, who serve the essential function of creating economic comparisons of alternative materials in commercial construction. CLTs are not included in these current cost estimation tools and software packages which may be limiting the potential use of CLT in …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
… at the pre- and post-synaptic terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the degradation of the synapse and subsequent cell death. …
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Automated conversion of milepoint data to intersection/link structure:an application of GIS in transportation
Network data restructuring is an essential function in Geographic Information Systems (GIS) when adapted to transportation. Implementing effective data restructuring models in GIS allows users to collect and maintain data in the format with which they are most familiar while allowing others to …
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Rab5 Activation by the Vps9 Domain
… these signals from the external milieu play an essential role in establishing and maintaining cellular homeostasis. As key regulators of the early stages the endocytic pathway, the small GTPases of the Rab5 family serve an essential function in integrating intracellular protein traffic and these …
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Mechanisms of p19Arf-Mediated Regulation of Perivascular Cell Biology During Mammalian Eye Development
… has been considerable evidence describing an essential function for p19Arf during mammalian eye development. In this context, p19Arf is required for the ultimate involution of the hyaloid vasculature system that exists in the primary vitreous space and serves to nourish the lens and retina. …
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A Novel Role for HAPLN1 in Skeletal Development
… zones. Collectively, our data suggest an essential function for Hapln1 that is potentially independent of its role in the ECM.
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Rab5 Activation by the Vps9 Domain
… these signals from the external milieu play an essential role in establishing and maintaining cellular homeostasis. As key regulators of the early stages the endocytic pathway, the small GTPases of the Rab5 family serve an essential function in integrating intracellular protein traffic and these …
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