Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 102 for “"enos"”.
-
PALMITATE INDUCED ENDOTHELIAL DYSFUNCTION: THE ROLE OF CALPAIN, AMPK AND ENOS
… of endothelial adhesion molecules via reduced eNOS derived eNO production (Rizzo NO et al., 2010; Davenpeck KL et al., 1994; Ahluwalia A et al., 2004). In this thesis, it was found that SFAs palmitate exposure dose dependently reduced endothelial AMPK thr172 and eNOS ser1177 phosphorylation by …
-
Long-Term Hypoxia Alters Ovine Fetal Adrenal eNOS and Cortisol Biosynthesis
… produced by endothelial nitric oxide synthase (eNOS) in the adrenal cortex, plays a significant role in regulating cortisol production in the LTH fetus. The production of NO is regulated by eNOS activity which can be altered via phosphorylation through key signaling pathways. In examining the …
-
LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE
The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide …
-
Der Einfluss des eNOS- Polymorphismus 894 G/T auf das Auftreten und den Schweregrad eines Lungenversagens
Ziel dieser klinischen Studie ist es, zu überprüfen, ob es einen Zusammenhang zwischen dem Auftreten sowie dem Schweregrad eines Lungenversagens und dem Polymorphismus 894G/T der endothelialen NO- Synthase gibt. Bei dem vorliegenden Polymorphismus handelt es sich um einen Austausch der Basen Guanin …
-
The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase
… expression of endothelial nitric oxide synthase (eNOS). Thus, it is critical to understand the mechanisms by which eNOS is regulated to identify new pathways and novel therapies for PPHN. eNOS is dynamically regulated at the transcriptional, post-transcriptional, post-translational, and …
-
The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase
… expression of endothelial nitric oxide synthase (eNOS). Thus, it is critical to understand the mechanisms by which eNOS is regulated to identify new pathways and novel therapies for PPHN. eNOS is dynamically regulated at the transcriptional, post-transcriptional, post-translational, and …
-
Einfluss von Drogenextrakten und Naturstoffen auf die endotheliale NO-Synthase
… Naturstoffen auf die endotheliale NO-Synthase (eNOS) in humanen Endothelzellen (Primärkulturen und Zelllinien). Insbesondere wurde dabei ihr Einfluss auf den verschiedenen zellulären Ebenen (Transkription, Proteinexpression, NO-Synthese) untersucht. Da es in dieser Arbeitsgruppe die erste Arbeit …
-
UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
… to bind endothelial nitric oxide synthase (eNOS) with submicromolar affinity via proposed interactions with a pentabasic non-canonical MAPK binding sequence in the autoinhibitory insertion of eNOS. The neuronal isoform, which lacks the pentabasic motif, did not bind either MAPK …
-
Dissecting the Molecular Basis of the Antiphospholipid Syndrome
… oxide (NO) produced by endothelial NO synthase (eNOS) prevents leukocyte adhesion and thrombosis. In the present study we determined if aPL-induced alterations in endothelial cell phenotype are mediated by aPL actions on eNOS. Normal human IgG (NHIgG) and human IgG containing polyclonal aPL were …
-
Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
… endothelial nitric oxide synthase (eNOS) is the primary NOS isoform expressed. The current study used cultured rat pulmonary myofibroblasts between passages two and five as a cell model. The cells were grown in normal growth media (DMEM + 10% FBS) or serum starved (DMEM + 0% FBS) to …
-
Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
<p>Endothelial nitric oxide synthase (eNOS) is part of a family of three nitric oxide synthase (NOS) enzymes that catalyze the production of nitric oxide (NO). NO is a gaseous, free-radical signaling molecule that has a variety of cellular and physiological functions that range from maintaining …
-
The mechanism(s) of post-transcriptional regulation of the human constitutive endothelial nitric oxide synthase gene by tumor necrosis factor-alpha
Endothelial nitric oxide synthase (eNOS) is an enzyme that catalyzes the formation of nitric oxide (NO) from the amino acid L-arginine and molecular oxygen, with the help of cofactors and a heme iron. It is one of three isoforms discovered as yet, and was first identified in endothelial cells …
-
Metabolic regulation of human vascular endothelial cell function in vitro
… produced by endothelial nitric oxide synthase (eNOS). Insulin is a vasoactive hormone that exerts its vasodilatory effects through eNOS-mediated NO production. Endothelial function is impaired in a number of disorders, including insulin resistance, diabetes and atherosclerosis, leading to …
-
Mechanismen der Urocortin-II-induzierten Stimulation der NO-Produktion in isolierten Kaninchen-Ventrikelmyozyten
… und Thr308 und der endothelialen NO-Synthase (eNOS) an Ser1177. Diese Wirkungen wurden durch Inhibitoren der Phosphatidylinositol 3-Kinase (PI3K), Wortmannin (0,3 µM) und LY294002 (10µM) nahezu vollständig aufgehoben. Konfokale Bildgebung der zellulären NO-Produktion und der fraktionellen …
-
Assessment od Adiponectin and Endothelial Nitric Oxide Synthase levels in Black Zambian patients with Hypertension at the University Teaching Hospital, Lusaka
… results showed that there was no difference in eNOS levels between hypertensive and non-hypertensive participants (p=0.197). Plasma adiponectin showed no correlation with eNOS in hypertension (r=0.036, p=0.825). Conclusion - The study showed that there was no difference in mean adiponectin …
-
ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… that ApoE3 activates endothelial NO synthase (eNOS) and thereby stimulates endothelial cell migration, and that both processes require ApoER2. In contrast, ApoE4 is incapable of activating eNOS and in fact blunts ApoE3 activation of eNOS migration. In eNOS-expressing 3T3 cells, we also found …
-
Mechanisms of soy isoflavones in the regulation of vascular function
… expression of endothelial nitric oxide synthase (eNOS) both in vitro and in vivo; (2) to define the mechanism by which genistein regulates eNOS expression; and, (3) to examine whether genistein protects against tumor necrosis factor-alpha (TNF-α)-induced apoptosis in human aortic endothelial cells …
-
The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development
… oxide synthase (NOS) isoforms, specifically eNOS and nNOS, are developmentally regulated, but their specific role and regulation are unknown.</p> <p>The enhanced vasodilatory role of NO in the immature kidney was hypothesized to be attributed to regulatory, expressional, and functional …
-
The effect of free fatty acids on endothelial cells
… acid, and arachidonic acid, does not alter eNOS protein content. However, PAEC incubation with the saturated FFAs (0-.6mM) palmitic and stearic acid, which do not undergo oxidative modification, dose dependently decrease eNOS content. The results of this study indicate that oxidized PUFAs …
-
Effects of Polyphenols on Vasomodulatory Factors and Associated Cell Signalling
… endothelial function. Specifically, Akt and eNOS phosphorylation, levels of total eNOS protein and cGMP, secretion of ET-1 and levels of nitrate/nitrite in cell culture media were assayed. Alongside these experiments, HUVECs were treated with quercetin, a flavonol found in a number of the …
Page 1 of 6