Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"eIF3"”.
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Eukaryotic Initiation Factor 3 Interactions with Structural Elements of Barley Yellow Dwarf Virus Untranslated Regions Reveal Details of a New Cap-Independent Translation Initiation Model
… complex eIF4F, the large scaffolding complex eIF3, and the 40S ribosomal subunit. Together eIF3, eIF4F, and BTE influence factor binding and 40S recruitment on the 5′ UTR and play a key role in facilitating BYDV translation. This report focuses on eIF3 by providing and analyzing data that …
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Identifying a role for nonessential elF3 subunits eif-3.K and eif-3.L in the regulation of endoplasmic reticulum homeostasis and longevity in Caenorhabditis elegans
… In this study, I report that homologs of eIF3 subunits elF3k and elF3I are nonessential in Caenorhabditis elegans, and that in their absence there is no defect in bulk protein translation. Surprisingly, mutants lacking these subunits exhibit both enhanced endoplasmic reticulum homeostasis …
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Identifying novel proteins in translation complex by using analytical ultracentrifugation with fluorescent detection system
… with the 5'-UTR of CLN2 mRNA. Components of the eIF3 and eIF2alpha complex were also found to be part of the 78S complex, although formaldehyde cross-linking was required to stabilize their association with this complex. These results confirm the utility of AU-FDS for charactering the …
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A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease
… and degrades Nup98, and may alternatively bind eIF3L and utilize the eIF3 complex as a targeting platform to cleave eIF4G. Cellular fractionation revealed Nup98 cleavage by 2A protease results in observable dissociation of Rae1 from the NPC as well as cytoplasmic accumulation of proteins …
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Charakterisierung zellulärer Interaktionsproteine des Nebenkapsidproteins L2 humaner Papillomviren
… werden konnte, besteht zwischen PLINP, eIF3, COP9 Signalosom und dem Proteasom. Eine Analyse der subnukleären Lokalisation konnte zeigen, dass PLINP in der Zelle sehr wahrscheinlich nicht nur in PODs, sondern auch partiell mit Mitochondrien assoziiert vorliegt. Es gab keinen Hinweis auf …
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Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
… DDX3X showed preferential interaction with eIF3 subunits, suggesting possible differences in how DDX3X and DDX3Y regulate translation. Proteomic analysis following DDX3X deletion or degron-tag-induced DDX3Y degradation was used to reveal translational targets of DDX3X and DDX3Y, and …
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Expression und Funktion des Apoptose-assoziierten Moleküls PHLDA1 im humanen Melanom
… des humanen Translationsinitiationsfaktor eIF3, bei dem anderen Gen um das MRG-Gen (mammary-derived growth inhibitor-related gene). Translations- initiationsfaktoren werden mit der Blockade der Proteinbiosynthese während der Apoptose in Verbindung gebracht und MRG ist als Gen identifiziert …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… ai pathway Fitness-OverT, tra cui eIF2, eIF3, CSTF e CPSF, in una coorte locale di CRC, nei campioni di adenocarcinoma del colon (COAD) del The Cancer Genome Atlas (TCGA) e nei modelli cellulari. La caratterizzazione molecolare delle linee cellulari di carcinoma colorettale è stata …
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Driver genes associated to Broad Copy Number Aberrations in solid cancers
… that some multi-subunit protein complexes (eIF2, eIF3, CSTF and CPSF) are candidate targets for silencing transcriptional therapy. At the end, in Glioblastoma multiforme the most recurrent chromosome aberration regards the gain of chromosome 7 alone or in combination with focal amplification of …