Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"domain mapping"”.
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Trim28 Interacts With Ezh2 to Regulate Its Activity
… RING finger, B-boxes and a coiled-coil domain (RBCC) and a C-terminal PHD/Bromo domain. Domain mapping revealed that the RBCC domain of TRIM28 interacts with EZH2, and the pre-SET region (Cysteine-rich domain) of EZH2 interacts with TRIM28. Transcriptome profiling and intersection of …
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Mapping Domains for ZIC3 Molecular Function
… All ZIC proteins contain a zinc finger domain (ZFD) and other evolutionary conserved regions. They are pleiotropic in nature since they can influence gene expression directly by acting as transcription factors due to their ability to bind target DNA sequences, or indirectly as co-factors …
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Mapping Domains for ZIC3 Molecular Function
… All ZIC proteins contain a zinc finger domain (ZFD) and other evolutionary conserved regions. They are pleiotropic in nature since they can influence gene expression directly by acting as transcription factors due to their ability to bind target DNA sequences, or indirectly as co-factors …
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Design patterns for work and organization structures to improve performance in Public-Private Partnerships
… method is proposed which uses morphological and domain mapping matrices to conduct a tradespace and scenario analyses. With this "generator" method, combinations of different breakdown rules across several layers of hierarchy lead to predicted varying levels of performance of the project. For …
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Disruptive adaptability : a case study in a product development organization
… Then, I used systems modeling tools such as Domain Mapping Matrix (DMM) and Design Structure Matrix (DSM) to understand and quantify the patterns of interaction among vehicle features that occur across all Electronic Component Units (ECUs) of an automobile. Finally I developed a holistic …
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Characterization of intracellular interactions between dengue virus and host proteins
… to study capsid-NAP1 interaction. I employed the domain mapping of capsid using yeast two-hybrid and co-affinity purification. I also over-expressed or silenced NAP1L1 in HepG2 cells stably expressing capsid. I found that NAP1L1 might bind the bipartite sequence of capsid blocking importin binding …
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Functional dissection of the S. cerevisiae helicase activating factor Cdc45
… algorithms and sequence conservation. Functional domain mapping of Cdc45 revealed that both N- and C-terminal segments are essential in vivo. Analysis of site-specific mutations identified five lethal and three temperature-sensitive site-specific mutations. Three of these mutations are within a …
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Deciphering the role of BRCA2 at the damage-induced G2 checkpoint
… by which BRCA2 regulates the G2 checkpoint. Domain mapping studies, using overlapping fragments encoding the full-length BRCA2 protein, carried out in our laboratory suggest that BRCA2’s function at the G2 checkpoint is mediated through regions that span BRCA2 amino acids (aa) 1-454 and aa …
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The evolution and diversity of noncanonical microbial nitrogen metabolisms
… which includes a cytochrome superfamily domain in addition to functional domains conserved in Proteobacterial nirS. Phylogenetic domain mapping reveals that this gene resulted from a chimeric domain fusion in ancestral Chloroflexi. I also identify an underreported variant of nitric oxide …
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Learning to map between domains
… a number of data-driven approaches for mapping from an 'unseen' or hard to understand domain to a 'seen' or easy-to-understand domain. Our work includes mapping between two image domains and mapping from an image domain to a language domain, which in computer vision are called, …
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Generation of Very Long Waves in Laboratory for Tsunamis Research
… equations, coupling with a computational domain mapping technique to estimate the moving shoreline. By comparing to the experimental measurements, the numerical models are verified and able to approximate the resulting waves in the wave tank. Surface waves studied in Boussinesq scaling …
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Dissecting The Interaction Between P53 and Trim24
… by their conserved RING, B-box, and coiled coil domains. Specifically, TRIM24 is a member of the TIF1 subfamily, which is characterized by PHD and Bromo domains in the C-terminus. Between the Coiled-coil and PHD domain is a linker region, 437 amino acids in length. This linker region houses …