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Showing 1 to 20 of 317 for “"cross-coupling"”.
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Iterative cross-coupling with MIDA boronates
… to small molecule making based on the iterative cross-coupling (ICC) of bifunctional haloboronic acid building blocks. Realizing a general ICC approach in the context of small molecule synthesis required the discovery of a ligand with the capacity to attenuate the reactivity of boronic acids …
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Development of organosilicon cross-coupling reaction
Use of palladium catalyzed cross-couplings have found widespread use in the pharmaceutical industry and there is a significant ongoing effort to either improve or devise new synthetic strategies to help build complex biologically active compounds. This is a study for advancing the use of silanols …
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Bimanual cross-coupling in space telerobotics
… Operator inputs to the bimanual controllers can cross-couple through not only inter-manual neuromotor pathways, when movement of one hand affects movement of the other hand, but also through intramanual pathways, when movement of one hand affects movement of the same hand in an unintended control …
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Cross-coupling reactions of unactivated alkyl halides
… development of palladium- or nickel-catalyzed cross-coupling reactions using unactivated alkyl electrophiles (e.g., halides and sulfonates). Although aryl and alkenyl electrophiles have been commonly used in such processes, the utility of alkyl substrates has been underdeveloped, and merits …
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Expansion of the iterative cross-coupling synthesis strategy through Csp3 halide cross-coupling, Mida boronate synthesis, and chan-lam couplings
The iterative cross-coupling strategy for small molecule synthesis has been shown to be a powerful and effective method for the synthesis of small molecules. However, this strategy was limited by current methodological limitations. Therefore, we have extended the power and application of the …
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Investigations Into Cross-Coupling of Secondary Organoboronic Esters
… were not viable substrates in the Suzuki-Miyaura cross-coupling reaction; however under recently reported conditions from the Crudden group1, which includes the addition of silver oxide to a palladium/phosphine catalyst system, this coupling can now be achieved. This thesis centres on optimizing …
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METAL-CATALYSED CROSS-COUPLING REACTIONS OF NITROGEN HETEROCYCLES
… reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid entry to tris(hetero)aryl scaffolds comprising two or three N-heterocyclic rings. The sequential N-C and C-C couplings can be performed in a …
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Stereospecific Csp3 cross-coupling for modular polyketide synthesis
Iterative cross-coupling represents a simple strategy for the synthesis of functional molecules that is inherently automatable. However, an important limitation to this platform is an inability to generate Csp3-rich, stereochemically complex molecules due to challenges in the coupling of alkyl …
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Development of Palladium(0)-Catalyzed Suzuki Cross-Coupling Polymerizations
… and reaction conditions, palladium(0)-catalyzed cross-coupling reactions would give us a good chance to achieve the goal. Thus, my Ph. D dissertation research projects focused on developing Pd(0)-catalyzed Suzuki cross-coupling polymerization reactions including controlled ones.</p> <p>My …
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Palladium catalyzed cross-coupling reactions of allyl- and vinylsilanes
Palladium-catalyzed cross-coupling of γ-substituted allylic silanolates with aryl bromides was investigated. It was discovered that γ-selectivity is heavily influenced by the substituents at silicon. It is proposed that undergoing an activated pathway significantly lowers the selectivity of the …
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Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents
… have been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with functionalized alkyl iodides in …
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Photoredox C–C Cross-Coupling Reactions using Boronic Acid Derivatives
… derivatives and subsequently engage them in C–C cross-coupling reactions. In the first chapter, an introduction to photoredox catalysis and organoboron reagents is provided, as well as a discussion on the key mechanistic aspects of photoredox catalysed C–C cross-coupling reactions. The second …
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Pd-Catalyzed Cross-Coupling, High Throughput Experimentation, and Machine Learning
… Monophosphine Ligands Promote Pd-Catalyzed C–S Cross-Coupling Reactions at Room Temperature with Soluble Bases. The Pd-catalyzed cross-coupling of thiols with aromatic electrophiles is a reliable method for the synthesis of aryl thioethers, which are important compounds for pharmaceutical and …
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Mechanistic studies on palladium-catalyzed C-N cross-coupling reaction
… studies employing simple aryl halide and amine coupling partners were performed to elucidate unknown reaction pathways. Chapter 1. The resting state for the palladium catalyzed cross-coupling of various diarylamines and aryl halides is found to be the diphenylamido complex. Kinetic studies of …
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Development and application of transition metal-catalyzed cross-coupling reactions
Chapter 1. PALLADIUM-CATALYZED REGIOSELECTIVE HYDRODEBROMINATION OF DIBROMOINDOLES A novel approach to the selective preparation of 4-bromoindoles has been developed via a Pd-catalyzed reaction. A variety of 4,6-dibromoindoles, which are prepared via Cu-catalyzed chemoselective C-N bond-forming …
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Palladium-catalyzed C-N and C-O cross-coupling reactions
… its dialkyl- or diarylbiaryl analogues. The C-N coupling was efficient for a wide range of (hetero)aryl chlorides and bromides under mild conditions. Chapter 2: This chapter relates the development of the Pd-catalyzed C-O coupling of primary alkyl alcohols. The reaction of primary aliphatic …
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Palladium-Catalyzed Cross-Coupling Reactions of Organosilanols: I. New Methods That Employ Alkynylsilanols and Bissilyl Reagents. II. Mechanistic Analysis of the Cross-Coupling of Aryldimethylsilanolates
… investigations of the palladium-catalyzed cross-coupling of aryldimethylsilanolates demonstrated that transmetalation proceeds directly from an arylpalladium(II) silanolate intermediate without external activation. Arylpalladium(II) silanolate complexes bearing phosphine ligands were …
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DEVELOPMENT OF BASE METAL-CATALYZED HYDROGEN TRANSFER AND CROSS-COUPLING REACTIONS
… the development of nickel-catalysed C-heteroatom coupling reactions following the ‘metallaphotoredox’ approach exploiting readily available organic photocatalysts. Thanks to their attractive features, (cyclopentadienone)iron complexes (CICs) have been applied in several transformations. However, …
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Nickel-catalyzed cross-coupling reactions involving secondary and tertiary alkyl nucleophiles
… introduction of transition metal-catalyzed cross-coupling reactions has been given. These transition metal-catalyzed C-C bond forming reactions have been used extensively in organic synthesis. Among them, C(sp2)-C(sp2) bond forming reactions have been widely studied over decades. More …
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