Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"core particles"”.
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Poly(ethyl glyoxylate) Solid-Core Particles for Drug Delivery
… to trigger the degradation of polymeric nanoparticles (NPs) by a specific stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger the …
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Relationship between Hepatitis B Virus Core Particles and Intracellular Motility
PURPOSE: Hepatitis B virus (HBV) core particles recycle back to the nucleus. This recycling mechanism is thought to be important in maintaining covalently closed circular (cccDNA) pool in the nucleus. Transport of HBV core particles in host cytoplasm is important for HBV life cycle but the …
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The Intracellular Changes and the Localization of Core particles by Hepatitis B Virus P Protein-Deficient Mutant
PURPOSE: Hepatitis B virus (HBV) core particles move to ER or recycle back to the nucleus. This moving mechanism is thought to be important in HBV replication and HBV life cycles. P protein-deficient mutant can form core particles in the absence of P protein and pregenomic RNA (pgRNA). In this …
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Deoxyribonuclease probing on sea urchin embryo chromatin
… are not significantly different. Nucleosomal core particles have been isolated from early blastula, gastrula and sperm of sea urchins. After DNase I digestion of 51-labelled core particles the rate constants of cutting of the DNA at the susceptible sites on these core particles have been …
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Initial Stages of Hepatitis B Virus Replication
PART 1 Intracellular Trafficking of HBV Core Particle in Various Stage of DNA Replication Inside of hepatitis B virus (HBV) core particle, pgRNA is reverse transcribed by HBV DNA polymerase into minus-strand DNA and pregenomic RNA (pgRNA) is degraded concomitantly by RNase H activity of DNA …
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Particle sensors based on amplified quenching of conjugated polymers for biosensing applications
… these attributes in a biosensor design, CPbased core-shell particles have been investigated as potential material platforms to detect protease activity. CP-based particles have greater sensitivity versus CPs in solution due to interchain and intrachain interactions afforded in the solid state. …
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An investigation into the significance of histone methylation in various mouse tissue
… level of histone methylation on the stability of core particles, chromatin and nuclei was investigated. The core particles and chromatin, isolated from tissues with different levels of histone lysine methylation, were 'melted' using UV thermal denaturation. No differences were found. It was …
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Generation of metal nanoparticles in spherical polyelectrolyte brushes and their application in heterogeneous catalysis
… as “nanoreactors” for the synthesis of metal nanoparticles (Gold, Platinum and Silver). The catalytic activity of the resulting metal/polymer nanocomposites has been tested by heterogeneous hydrogenation of carbonyl groups. The synthesis of the cationic spherical polyelectrolyte brushes is …
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Assessing the Influence of mineralogy and texture on the ore breakage characteristics of drill core and crushed ore using the JKRBT
… tool which can use both crushed ore and drill core samples. Drill core is especially important as it the material used for geometallurgical testing during exploration and resource definition. The JKRBT is more accurate and the test work is less time consuming than its predecessors. However, …
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Ore breakage characterisation of UG2 deposits using the JK RBT
… (particle selection method) and cut drill core particles (cut core method). A mineralogical analysis of UG2 chromitite, pyroxenite, spotted anorthosite and mottled anorthosite was performed using Leica EZ4D optical microscope and QEMSCAN 650F to determine their mineral composition and …
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Modulation of Cis-syn Cyclobutane Dimer Formation and Deamination at CpG sites by Nucleosome Particles and Its Implications for Deamination Bypass Mechanism for the Origin of C to T Mutations
… of CPDs in a chicken erythrocyte nucleosome core particle reconstituted with synthetic DNA. We found that the deamination of a TmC CPD whose sugar phosphate backbone is positioned against the histone core surface decreases by a factor of 4.7, whereas that of a TmC CPD positioned away from the …
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Phenotypic characterization of a clinical HBV/G isolate relative to a co-infecting HBV/A strain and HBV/A/G recombinant strains
… which contains a 36-nucleotide insertion in the Core gene as well as 2 mutations that lead to stop codons in the Pre-Core coding region. Chronic infection with HBV/G is not known to occur without a co-infecting HBV genotype, suggesting that it is defective on its own. This study aims to look at …
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Charged polymer-macroion complexes
… for individual DNA-histone complexes (nucleosome core particles) along the chromatin fiber. A numerical method is introduced in this thesis based on a simple generic chain-sphere cell model that enables one to investigate the mechanism of fiber formation on a systematic level by incorporating …
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Synthesis, Characterization and Structure-Property Relationships of Polymer-Stabilized Nanoparticles Containing Imaging and Therapeutic Agents
… the fabrication of polymer-stabilized nanoparticles encapsulating imaging and therapeutic agents and delineates relationships among materials parameters and response. The effect of aggregation of magnetic iron oxide nanoparticles in aqueous suspension was characterized using a well-defined …
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Functional Role of Hepatitis B Virus Core Protein in Viral Replication
… nucleic acid binding domain of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for the corresponding regions of HBV core protein. …
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REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA
… within packaged eukaryotic DNA is the nucleosome core particle (NCP). The NCP consists of a 146 bp DNA fragment wrapped around an octamer of histone core proteins. Nucleosome core particle formation induces DNA structural changes and reduced DNA accessibility providing a very different setting …
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REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA
… within packaged eukaryotic DNA is the nucleosome core particle (NCP). The NCP consists of a 146 bp DNA fragment wrapped around an octamer of histone core proteins. Nucleosome core particle formation induces DNA structural changes and reduced DNA accessibility providing a very different setting …
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Theory of slow coupled translational-rotational dynamics and viscoelasticity of nonspherical particle suspensions
… translational and rotational motions of uniaxial particles within the interaction site formalism. The approach is based on the time-dependent scalar displacements of the particle CM and cumulative rotational angle as the relevant slow variables, and a two-dimensional dynamic free energy surface …
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Effect of ceria and zirconia on nanoparticulate rhodium catalysts
Rh metal was implemented as a core component in the so-called three-way automotive exhaust catalyst (TWC) due to its excellent properties such as thermal stability, poison resistance and inert behaviour to react with any support materials. These catalysts are often loaded with small amount of …
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