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Showing 1 to 20 of 50 for “"complement system"”.
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The Role of the Complement System in Mousepox Infection
… immunomodulatory virulence factors, including a complement regulatory protein. Ectromelia virus provides a mouse model for human smallpox infection where the virus and the host's immune response have also co-evolved. Using this model, we investigated the role of the complement system in a …
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Studies of EHEC and the complement system in renal diseases
… Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). EHEC is a non-invasive highly virulent bacterium. In order to gain access to the circulation it first damages the intestinal mucosa. The mechanism of damage …
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Molecular Interactions of Human C9: The Pore Forming Protein of the Complement System
<p>The human complement system is part of our innate immunity that acts to eliminate pathogenic organisms. Activation of complement leads to the sequential, non-enzymatic assembly of C5b, C6, C7, C8, C9 forming C5b-9<sub>n</sub> (n=12-18), a cytolytically active pore-like structure known as the …
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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
… I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed …
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Investigating the role of the complement system in the pathogenesis of sub-retinal fibrosis in neovascular age related macular degeneration
… Transition (MMT). <br/><br/>The complement system has been widely recognised to play a role in AMD and retinal dysfunction. Our group has previously shown that complement component C3a is increased in the serum of patients with sub-retinal fibrosis. Chapter 5 presents the findings …
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Multivariate Statistical Analysis In Single Cell Transcriptomics
… and 5 dive further into a specific pathway, the complement system. It is well known that the complement system shapes homeostasis in immune-privileged organs such as the brain and the retina, and that intracellular complement also regulates cellular metabolism. In Chapter 4, we describe analysis …
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Interaction of Bacillus Anthracis Exosporium Protein Bcla With Complement Factor H and Spore Persistence In The Lung
… spores into the host via the respiratory system, the gastrointestinal tract, cuts or wounds in the skin, and injection. Among these four forms, inhalational anthrax has the highest lethality rate and persistence of spores in the lungs of animals following pulmonary exposure has been noted …
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
… or neutralise the host defence including the complement system. We demonstrate that H. influenzae interferes with both the classical/lectin and alternative pathways of the complement system. NTHi binds C4BP, the inhibitor of the classical pathway, and the majority of the H. influenzae tested …
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Probabilistic Approximation and Analysis Techniques for Bio-Pathway Models
… of bio-pathway dynamics is crucial to the system-level understanding of cellular functions and behavior. Currently, a common method of representing bio-pathways is through a system of ordinary differential equations (ODEs). However, calibrating and analyzing large ODE-based pathway models …
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The role of cell autonomous complement in B cell function and regulation
… are not fully understood, including the role of complement system - an ancient arm of the innate immune system that also plays a key role in B cell biology. It is well-known that extracellular complement receptor signaling, and complement-tagging of antigen is necessary for the activation and …
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Die Untersuchung zellulärer inflammatorischer Prozesse bei Pseudoxanthoma elasticum
… <br /><br /> In the first part of this study the complement system and inflammatory pathways were analyzed in human dermal fibroblasts from PXE-patients (PXEF). An upregulation of different complement factors was detected in the PXEF. Especially complement factors of the classical and alternative …
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Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
… ideas about the aetiology and pathogenesis of systemic lupus erythematosus (SLE). The disease is characterized by broad-spectrum organ manifestations, multiple autoantibodies and multifactorial immunological pathogenesis. Lupus nephropathy is one of the most severe, significant and common …
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Functional and Structural Characterisation of Spy0136, a Novel Group A Streptococcal Virulence Factor
… Spy0136 was found to bind C1s, C1r, C3, C5 complement proteins, and fibrinogen, suggesting a potential involvement of this protein in immune evasion mechanisms. This binding was shown to be glycan-dependent for C1s, C3, and C5. Functional analysis of Spy0136 in host immune evasion revealed …
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The Role of Complement in Ischemic Heart Disease in Type 2 Diabetes Mellitus
… recognized by reactive oxidant production, complement activation, and leukocyte-endothelial cell adhesion, among others. Complement activation plays an important role in the inflammatory response and is involved in the manifestation of I/R injury in the non-diabetic heart, and is a potent …
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Association of <i>glpQ</i> with serum-resistance in <i>salmonella typhimurium</i>
… cause of infectious human gastroenteritis and systemic disease when it escapes into the bloodstream. The human serum complement system is central in fighting systemic bacterial infections. <em>S. typhimurium</em> exhibits resistance to killing by complement (serum-resistance), a trait conferred …
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The role of anaphylatoxins in asthma and airway remodelling
… are proinflammatory polypeptides released during complement activation. They exert their biological functions by interacting with the G protein-coupled receptors, C3aR and C5aR respectively. Activation of the complement system has been implicated in the pathogenesis of many inflammatory diseases …
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THE ROLE OF BACTERIAL AMYLOID FIBRILS IN ESCHERICHIA COLI COMPLEMENT RESISTANCE
… factors which make them more resistant to the complement system. The bacterial amyloid fibril, curli, functions in bacterial adherence and the formation of biofilm. Curli-producing parental and curli-deficient mutant E. coli was compared in its survival to human complement, using in vitro serum …
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