Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"comparative transcriptomics"”.
-
Comparative transcriptomics of long intergenic noncoding RNAs in Drosophila
… investigation. This work represents the first comparative transcriptomic analyses of lincRNAs in Drosophila.
-
Unraveling the neurogenin/ngn-1 gene regulatory network of C. elegans using classical genetics and comparative transcriptomics
… embryonic development. Using RNA sequencing and comparative transcriptome analysis we found that <em>ngn-1</em> acts primarily to repress transcription, facilitating proper embryogenesis. We also identified specific candidates for activation by <em>ngn-1</em>, including <em>hlh-34</em>(NPAS1) and …
-
Comparative transcriptomics and co-expression networks reveal tissue- and genotype-specific responses of QDTYS to reproductive-stage drought stress in rice (Oryza sativa l.)
Rice (Oryza sativa L.) is more sensitive to drought stress than other cereals. Particularly during reproductive stages, drought causes yield reductions of 50-80%. With at least 25 million hectares of drought-prone rainfed rice, drought remains a major environmental constraint to rice production. …
-
Investigation of ocular drug metabolism and pharmacokinetics using multi-omics and in-situ microdialysis
… drug metabolism and disposition by integrating comparative transcriptomics, targeted proteomics, functional enzymatic activity, and in vivo ocular pharmacokinetic characterization in rabbit tissues.
-
Gillenia trifoliata: a tool to understand the genetic regulation of apple flesh development
… standardisation tool and genomic resource for comparative analyses. Genome-wide analysis of select gene families revealed conserved genome dynamics related to flower and fruit development. Interspecies comparative transcriptomics and bioinformatics revealed the importance of A- and E-type …
-
Transcriptomics to gene expres[s]ion : analysis of the ontogeny of sexual dimorphism in a crustacean, Euphilomedes carcharodonta
… evolution, as this data is a first step towards comparative transcriptomics and gene expression studies comparing multiple species.</p>
-
Analysis of the role of velvet and laeA in the molecular interactions between grass and Epichloë fungal symbionts
… inoculated seedlings with both mutants. A set of comparative transcriptomics analyses identified a range of biological processes influenced by VelA and LaeA, some of which were inferred as required for a mutualistic interaction. Investigation of the ryegrass transcriptome in compatible versus …
-
Computational Analysis of Gene Expression Regulation from Cross Species Comparison to Single Cell Resolution
… species. This trend enables us to perform comparative transcriptome analysis that identifies conserved or diverged gene expression responses across species using transcriptome data. The goal of this dissertation is to develop and apply approaches of comparative transcriptomics to transfer …
-
Integrating bioinformatic approaches to promote crop resilience
… pimpinellifolium under combined stresses—using comparative transcriptomics, and 3) develop a genome assembly pipeline that can be deployed to rapidly assemble a more contiguous genome, unraveling previously hidden complexity, using Phytopthora capsici as a model. As a result, we have generated …
-
CHARACTERIZATION OF CA²⁺-MEDIATED VIRULENCE AND MICROBIAL COMPETITION IN THE PLANT PATHOGEN PSEUDOMONAS SYRINGAE
… encodes for a β-class carbonic anhydrase, by comparative transcriptomics. The transcriptomics analysis across different media and conditions supplemented with calcium revealed that cynT influences the expression of virulence and metabolic genes in a context-dependent manner, and deletion of …
-
Mechanisms involved in eusocial evolution in bees
… wasps, ants and termites. In Chapter 3, I use comparative genomics to search for genes involved in convergent evolution of sociality using new genomic resources I developed for a set of 10 socially diverse bee species. This study identifies genes and biological processes that are evolving more …
-
Transcriptional divergence during cichlid embryogenesis
… to species diversification with the use of comparative transcriptomics. The study focuses on two Lake Malawi cichlid species representing distinct eco- morphological groups: the ancestral-like generalist Astatotilapia calliptera and the specialized mbuna (rock-dwelling) algae-scraper …
-
Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
… in S. cerevisiae, I next</p><p>performed a comparative transcriptomics study on cell-cycle genes in the less studied,</p><p>but more human health relevant fungal pathogen, Cryptococcus neoformans. This work</p><p>not only begins to identify a cell-cycle network in C. neoformans but also …
-
Genomic, transcriptomic, and metagenomic approaches for detecting fungal plant pathogens and investigating the molecular basis of fungal ice nucleation activity
… the strength of INA. Whole genome sequencing and comparative genomic studies were then performed to identify putative INA genes. Differential expression analyses at different growth temperatures were also performed. INP properties of the two species shared similarities, both appearing to consist …
-
Convergent Evolution of Biochemical Innovations in Polychaetes: Characterizing the Molecular Basis of Bioluminescence and Venom Production
<p>The convergent evolution of phenotypic traits is a widespread phenomenon across the tree of life and is explained as the outcome of different taxa facing similar selective forces or environmental conditions. A longstanding question in evolutionary biology is whether the evolution of convergent …
-
Transcriptomic analysis of pancreatic cells in zebrafish
… this set of conserved genes. This interspecies comparative analysis highlighted genes with evolutionary conserved expression whose pancreatic function is still unknown, but also revealed striking differences in gene expression patterns between species. The goal of the second part of my thesis …
-
Development of a comprehensive annotation and curation framework for analysis of Glossina Morsitans Morsitans expresses sequence tags
This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source Glossina resource (G-ESTMAP) was developed that provides interactive features and …
-
Genomic regulation of social behavior in eusocial bees
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
-
Integrative transcriptomic approaches to analyzing plant co-expression networks
It is well documented that transcriptionally coordinated genes tend to be functionally related, and that such relationships may be conserved across different species, and even kingdoms. (Ihmels et al., 2004). Such relationships was initially utilized to reveal functional gene modules in yeast and …