Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"clarithromycin"”.
-
Clarithromycin nanocrystals for high-dose inhalation
… inhalable dry-powder approach to deliver clarithromycin locally. Poorly soluble clarithromycin (BCS II) was converted to nanocrystals by wet media milling. Spray-dried hollow microparticles, so called "Trojan particles", in which nanocrystals are incorporated in a matrix shell are designed …
-
Removal of Metformin and Clarithromycin from aqueous media using Magnetic Brewery Spent Grain
… prioritised pharmaceuticals, metformin (MF) and clarithromycin (CLR). Response surface methodology (RSM) was applied to identify optimal adsorption parameters for the most promising material, magnetic brewery spent-grain biochar (MBSG). Under these optimal conditions removal efficiencies of 100% …
-
Macrolide Resistance in Mycobacterium avium
Mycobacterium avium isolates resistant to clarithromycin and azithromycin have been recovered from patients undergoing antibiotic therapy. Comparison of DNA fingerprints of sensitive and resistant isolates showed that resistance resulted from mutation of the original, sensitive isolate in five of …
-
Development and application of Helicobacter pylori surveillance to improve antimicrobial treatment
… metronidazole resistance was present in 59% and clarithromycin resistance was in 11% of the 101 H. pylori isolates. Of 363 isolates from rural Bangor, North Wales, 23% were metronidazole resistant and 7% were clarithromycin resistant. Combined clarithromycin and metronidazole resistance occurred …
-
Development of Drug Loaded Nanoparticles for Treatment of Mycobacterium avium Infection
… done with a) amikacin-loaded nanoparticles, b) clarithromycin-loaded nanoparticles, and c) with aerogel nanoparticles loaded with rifampicin, clarithromycin and ethambutol. Clarithromycin (CLA) and amikacin (AMK) loaded nanoparticles showed a significant reduction in viable M. avium compared to …
-
Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery.
… drugs, including ibuprofen, saquinavir, and clarithromycin. Dissolution experiments were conducted using both ibuprofen and caffeine, and results suggest that SAIB can be used in dosage forms to control release rate. Pharmacokinetic studies in which laboratory rats were dosed with …
-
The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori
… for Helicobacter pylori infections, with the clarithromycin triple therapy, is only 75%. The triple therapy, which consists of a proton pump inhibitor and two broad-spectrum antibiotics such as clarithromycin and amoxicillin, is becoming less effective due to the rise of strains with …
-
Pharmaceutical occurrence, distribution and degradation in rural wastewaters and surface waters in Scotland
… anti-inflammatory drugs); clarithromycin and trimethoprim (antibiotics); carbamazepine and fluoxetine (psychoactive drugs); and 17α-ethynylestradiol (synthetic hormone).<br/>Overall, results suggest that the studied rural community produced wastewater with significant …
-
Establishment of a Long Term Cell Culture Model for Testing Anti-Infectives against Mycobacterium avium subsp. paratuberculosis
… minimal cost. We have evaluated the efficacy of clarithromycin, azithromycin, isoniazid, amikacin, ethambutol, ciprofloxacin, levofloxacin, rifampicin, clofazimine, as well as a combination of clarithromycin, rifampicin, and clofazimine using our MAP infected macrophage cell culture model. We …
-
Investigating human pharmaceutical compounds present in municipal and hospital wastewaters and options for their removal
… bezafibrate, carbamazepine, atenolol, lidocaine, clarithromycin and sulfamethoxazole (< 1μg/L). Antibiotic drugs were detected in HWWTPs, but rarely detected in MWWTPs. In general, the hospital wastewaters contained relatively higher levels of pharmaceuticals than municipal wastewaters. The …
-
Effektivität der neuen 7-Tage-Tripel-Therapie mit Esomeprazol, Rifabutin und Amoxicillin bei Infektionen mit Makrolid- und Imidazolresistenten Helicobacter pylori Stämmen
… kulturell nachgewiesenem gegen Metronidazol und Clarithromycin doppeltresistentem Helicobacter pylori, mit der Rifabutin-Tripel-Terapie ( ERA – 2 x 20 mg Esomeprazol, 2 x 150 mg Rifabutin und 2 x 1000 mg Amoxicillin über 7 Tage) oder der modifizierten Hochdosis-Dualtherapie (mOA – Omeprazol 3 x …
-
Pullulan w-carboxyalkanoates for Drug Nanodispersions
… of the HIV drug ritonavir and antibacterial clarithromycin. However, these cellulose derivatives have limitations due to their limited water solubility. Natural pullulan is water-soluble and modification with w-carboxyalkanoate groups would provide a unique set of derivatives with increased …
-
Genomic diversity in naturally transformable Streptococcus pneumoniae
… pneumococcus to an antimicrobial (clarithromycin) commonly used to treat pneumococcal pneumonia.
-
Synthesis of New Pullulan Derivatives for Drug Delivery
… great potential for biomedical applications. Clarithromycin (CLA) is an aminomacrolide antibiotic whose physical properties are fascinating and challenging. It has very poor solubility at neutral intestinal pH, but much higher solubility under acidic conditions. Therefore, CLA dissolves better …
-
Tetracyclin-Resistenz in Helicobacter pylori : Herstellung und Charakterisierung von definierten 16S rRNA-Mutanten und Etablierung eines Realtime-PCR Ansatzes zur schnellen Resistenzbestimmung
… gegen die Antibiotika der ersten Wahl wie Clarithromycin und Amoxicillin, welche in der H. pylori-Eradikationstherapie verwendet werden, nimmt die Bedeutung von alternativen Therapieschemata wie z.B. solchen mit Tetracyclin immer mehr zu. <br>Die weitaus meisten H. pylori-Stämme sind …
-
Effect of growth in biofilms upon antibiotic and chlorine susceptibility of Mycobacterium avium and Mycobacterium intracellulare
… and cells grown in biofilms was measured against clarithromycin, ethambutol, kanamycin, rifampicin and streptomycin. Cells grown in biofilms and exposed to antibiotics in biofilms were five-fold resistant to antibiotics than were cells grown in biofilms and exposed in suspension. Cells grown and …
-
Synthesis and Antimicrobial Activity of Half-Sandwich Ir(III), Rh(III), and Co(III) Complexes
… drug resistance of these mutants was shown with clarithromycin. The DNA of the 23s ribosomal subunit was sequenced revealing a deletion/insertion mutation within domain V (bases 2057-2058).
-
Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients
… for better treatment. Three antibiotic drugs – Clarithromycin (CLA), Rifabutin (RIF), and Clofazimine (CLO) have been used to treat CD patients suspected with MAP infection. However, the outcome has been controversial. The treatment dosage is high, the duration is long, and the reported drug …
-
Identifikation von Mutationen im Tumorsuppressorgen p53 und des Bakteriums Helicobacter pylori in Magenkarzinomen histopathologischer Präparate aus verschiedenen medizinhistorischen Sammlungen
… Mutationen gegen das Antibiotikum Clarithromycin in den historischen Geweben identifiziert werden. Die vorliegende Arbeit konnte p53-Mutationen und das Bakterium H. pylori in den historischen Gewebeproben identifizieren. Ein verändertes Mutationsspektrum und die veränderte …
-
Potential groundwater contamination from pit latrines in Ga-Maja and Reefentse
… isolates displayed resistance to the macrolides (clarithromycin and erythromycin), amoxicillin-clavulanic acid, ciprofloxacin, and gentamicin. There was high resistance to many antibiotics particularly ampicillin (77%), norfloxacin (85%) and tetracycline (85%). Undesirable properties of water …
Page 1 of 2