Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"circadian pacemaker"”.
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Adolescent sleep and the circadian pacemaker
… mental development. Adolescents often exhibit a circadian phase delay in which they tend to go to bed later and wake up later compared to adults. This thesis seeks to understand the adolescent phase delay and its relationship to the circadian pacemaker, the body’s master clock. Using a dynamic …
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Cell Signaling Components of the Drosophila Circadian Pacemaker
… and are required in a specific set of pacemaker cells in the Drosophila brain for locomotor rhythms. These cells are divided into distinct subgroups and evidence suggests that subgroups of pacemaker cells may control distinct components of circadian behavior although these assignments …
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Regulation of the suprachiasmatic circadian pacemaker by serotonin and neuropeptide Y in vitro
Made available in DSpace on 2011-05-07T14:27:17Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9543662.pdf: 4374167 bytes, checksum: 07d9da4452632e2043ead8592edaf5e2 (MD5) Previous issue date: 1995
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Investigation of the SCN 2.2 Cell Line as a Model of the Central Mammalian Circadian Pacemaker
… of the SCN, which is the central mammalian circadian pacemaker. Extensive characterization of differentiated SCN 2.2 cultures revealed that this cell line expresses putative clock genes, as well as components of daytime, nighttime and crepuscular circadian regulatory pathways. The line also …
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Windows in the clock: An in vitro study of melatonin action and signal transduction in the suprachiasmatic circadian pacemaker
… to regulate the functioning of this primary circadian pacemaker. By isolating the rat SCN in vitro in a hypothalamic brain slice preparation, we have demonstrated a direct resetting of the SCN pacemaker's rhythm of ensemble neuronal firing rate in response to exogenous melatonin treatment. …
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Cholinergic regulation of a mammalian circadian clock
… carbachol, has been shown to shift the phase of circadian rhythms in rodents when injected intracerebroventricularly. However, the site and receptor type mediating this action have been unknown. The suprachiasmatic nuclei (SCN), the primary circadian pacemaker in mammals, continue to show a …
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Fetal tissue containing the suprachiasmatic nucleus restores circadian rhythms in old rats
Circadian rhythms of body temperature, locomotor activity, and drinking in many rats deteriorate or even disappear with age. The suprachiasmatic nucleus (SCN) in the anteroventral hypothalamus has been identified as the major circadian pacemaker in mammals. When fetal tissue containing the SCN is …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
Circadian rhythms are recurring patterns in behavioural, physiological, and other parameters that display periods of approximately every twenty four hours. The molecular basis of the circadian timekeeping involves clock genes which act as transcription factors in a serious of feedback loops. …
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Pituitary Adenylate Cyclase -Activating Peptide Signaling in the Mouse Circadian Clock
… light/glutamate-induced phase resetting of the circadian clock, yet the particulars of this role remain controversial. Mice generated by Lee Eiden and colleagues that do not express PACAP were examined to test the hypothesis that PACAP plays a physiological role in light or glutamate-induced …
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The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
… (SCN), that contains the mammalian central circadian clock. The 20,000 clock neurons in the SCN are responsible for interpreting photic signals and orchestrating oscillations in peripheral tissues. In this study, I demonstrated the “unusual” and “non-canonical” roles of Sox2 in these …
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Circadian desynchrony in the mouse: how does chronic exposure to rotating shift work-like patterns of light/dark affect circadian rhythms and neurobehavioural outcomes
Disruption of circadian rhythms is associated with several deleterious health consequences, increased prevalence of obesity, maladaptive changes in affect, and cognitive impairment. Still it is estimated that as much as 20% of the work force are exposed to this risk factor experiencing some degree …
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Functional Organization and Information Processing Within the Suprachiasmatic Nucleus Assessed by Multiunit Recording in Vitro
… contains a network of interconnected cellular circadian pacemakers. The functional organization of circadian pacemaker activity, and information processing in the SCN were examined using electrophysiological methods in vitro. A novel carbon fiber bundle (CFB) multiunit electrode was developed …
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Analysis of Circadian Rhythm Using a Novel SCN-Specific Cre Transgenic Mouse Line
… nucleus (SCN) temporally organize behavior into circadian cycles of activity and rest. When dissociated, these neurons individually oscillate with various period, phase, and amplitude. These conflicting results can be reconciled if inter-neuronal networking in the SCN is required for a …
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PHYSIOLOGICAL CONSEQUENCES OF CIRCADIAN DISRUPTION BY NIGHTTIME LIGHT EXPOSURE
… organisms have developed endogenously driven circadian rhythms which are synchronized to this light/dark cycle. In recent years, daily light schedules have become artificial and irregular due to the use of electric lighting. In this dissertation, I propose that exposure to light at night (LAN) …
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The roles of vasoactive intestinal polypeptide in circadian entrainment of suprachiasmatic nucleus
… daily behavioral and physiological rhythms as a circadian pacemaker. The 20,000 SCN neurons synchronize to each other and to the ambient cues to generate coherent daily rhythms. Vasoactive intestinal polypeptide: VIP), a neuropeptide produced by SCN neurons, plays a major role in synchronizing …
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Cellular Mechanisms Underlying the Action of Melatonin in the Suprachiasmatic Nucleus
… Recent attention has focused on its role in circadian physiology. The suprachiasmatic nucleus (SCN) is the circadian pacemaker in all mammals. Melatonin phase advances the circadian rhythm of the activity of the SCN neurons when administered at specific times of the day. This effect is more …
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Seasonal regulation of the circadian rhythms of behavioural temperature selection and locomotor activity in Australian sleepy lizards (Tiliqua rugosa, gray; reptilia: scincidae)
… examined the role of environmental time cues and circadian rhythms in mediating seasonal adjustments in the body temperature and locomotoractivity patterns in the Australian sleepy lizard, Tiliqua rugosa (Gray 1827). The first component of this study investigated whether daily rhythms of …
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Possible Influences of Circadian Melatonin on the Function of Neurosecretory Neurons and Serotonin-Modulated Behavior on Crayfish.
… zur Verhaltenskontrolle und zur Untersuchung circadianer physiologischer Rhythmen. Ob das in verschiedenen Krebsarten beschriebene stereotype agonistische Verhalten durch circadiane Schrittmacher kontrolliert wird, habe ich Gruppen von parthenogenetisch reproduzierenden Marmorkrebsen …