Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"cellular expression"”.
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Molecular and cellular expression of novel genes associated with breast cancer
… extensive in silico analysis and in vitro expression analysis for all genes using sequencing and RT-PCR based assays on a variety of tissues of normal and cancerous origin in order to further select the most promising candidates for potential use in cancer care. In light of all the data …
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FROM SERUM TO TISSUE: GALECTIN-BINDING GLYCOFORMS OF SERUM GLYCOPROTEINS AS FUNCTIONAL BIOMARKERS
… variety of roles. Our findings suggest a basic cellular mechanism– galectins use their unique fine specificities to bind and regulate the cellular trafficking of glycoproteins, which could lead to functional effects, such as targeting a glycoprotein to either side of a cell, changing the time it …
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Autoencoding variational inference for the visualization of velocity-enriched scRNA-seq data
… reduction is often used to visualize complex expression profiling data. The embedding of expression data is typically based solely on expression levels, which can yield inaccuracies in the representation of the lower-dimensional data. By augmenting scRNA-seq data with velocities for each cell, …
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Poly ([beta]-amino ester)s as pH sensitive biomaterials for microparticulate genetic vaccine delivery
… is the administration of nucleic acids to induce cellular expression of antigens, leading to an immune response. Unlike traditional vaccines, this technology has tremendous potential for treating or preventing diseases such as HIV, malaria, and cancer. However, this potential is currently …
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Characterization in cochlea of KCTD12/PFET1, an intronless gene with predominant fetal expression
… cochlear transcript with predominantly fetal expression containing a single tetramerization domain (PFET1, HUGO-approved symbol KCTD]2) was identified from the Morton fetal cochlear cDNA library. KCTD12/Kctd]2 is an evolutionarily conserved intronless gene encoding a 6 kb transcript in human …
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Isopeptide and Ester Bond Ubiquitination Regulate Degradation of the Human Dopamine Receptor 4
… of the primary structure of one of the intracellular loops of the hD4R can vary dramatically among individuals. Attempts have been made to correlate different VNTR structures with different behavioral traits – for example, a specific variant of hD4R is robustly correlated with attention …
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The Effect of Primary Hepatocyte Expressing HBx on the Activation and Apoptosis of Antigen-specific CD8+ T Cell
… HBV infection. Since HBx is able to upregulate cellular expression level, it is thought that HBx may modulate CD8^(+) T cell immune response. To test this hypothesis, proliferation, cytokine production and apoptosis of CD8^(+) T cells co-cultured with hepatocytes expressing HBx were analyzed. …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
… enough to induce mitochondrial elongation with cellular senescent phenotypes, whereas ethidium bromide (100ng/ml) which was employed to damage mtDNA only reformed cristae structure. TTFA, which is known to complexⅡ inhibitor was induced fragmentation of mitochondria. Elongated giant mitochondria …
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The role of Cited2 in left-right patterning and placental development in the mouse
… many organs in the mouse. Territories of Cited2 expression in the mouse coincide with the tissues most affected in Cited2 null mice. Embryos deficient in Cited2 display complex heart defects that may have multiple origins. One possibility is that the establishment of the left-right body axis that …
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Secondary anchor targeted cell release system
… heterogeneities in patient’s cell receptor expression limits advancement in personalized medicine. These individual differences in receptor quantities can give rise to both intrinsic and acquired resistances to therapeutics, which result in reduced treatment efficacy. In diseases like …
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Behavioral and genetic characteristics of intestinal cell lineages in health and disease
… turned our attention to quantifying the spatial expression patterns of selected transcripts in the intestinal crypt, both in wildtype and in an inducible APC-loss cancer model. We were able to show that the transcript expression profiles of key differentiation and proliferation markers (Creb313, …
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Causal Representation Learning for Predicting Genetic Perturbation Effects on Single Cells
… of previously unseen genetic perturbations on cellular expression profiles. While existing deep learning approaches excel at interpolating within observational data, they often struggle to extrapolate to novel perturbations. To address this limitation, this study introduces a hybrid framework …
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The Role of Phosducin-like Protein and the Cytosolic Chaperonin CCT in G beta gamma dimer Assembly
… of PhLP in G protein signaling was investigated. Cellular expression of PhLP was blocked using RNA interference targeting PhLP. Together with overexpression of PhLP variants and kinetic studies of G protein beta gamma dimer formation, PhLP was determined to be a positive mediator of G protein …
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Estrogen Receptors and Estrogen-Regulated Genes in the Male Reproductive Tract
… Therefore, in the first part of this thesis, the cellular expression of androgen (AR) and estrogen receptors, ERalpha and ERbeta, were investigated by immunohistochemistry in the adult male mouse reproductive tract. It was demonstrated that ERalpha is expressed in a region and cell specific manner …
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Investigation of the ABI3 protein in microglia and its association with Alzheimer’s disease in TgCRND8 mouse model
… this thesis was aimed at analysing the expression and cellular function of ABI3 in microglia within the context of AD pathology in the CRND8 transgenic mouse model. Initially, commercial ABI3 antibodies were tested for their specificity in detecting endogenous ABI3 protein, using ABI3 …
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Differential expression of C/T antigens and 5-HT receptors in normotensive and pre-eclamptic placentae, and their role in trophoblast invasion
… between NT and PE placenta. However, the expression patterns of all known 5-HT receptors in PE placentae have not been fully investigated, even though the 5-HT mediates its various actions via these receptors. Likewise, the status of C/T antigens which are also proposed to be involved in …
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REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
… evidence supports the notion that reduction of cellular expression and activity of antioxidant proteins and the resulting increase of oxidative stress are fundamental causes in the aging processes and neurodegenerative diseases. Within the frame of free radical hypothesis of aging, several lines …
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Coaxial double-walled microspheres for drug and gene delivery applications
… and evaluated in terms of growth inhibition, and cellular expression of tumor suppressor p53 and apoptotic caspase 3 proteins in human hepatocellular carcinoma HepG2 cells. Overall, the combined doxorubicin and chi-p53 treatment exhibited enhanced cytotoxicity as compared to either doxorubicin or …
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Functional and behavioural characterisation of C. elegans acid-sensing DEG/ENaCs
… of the C. elegans DEG/ENaC family regulate cellular processes and drive behaviour. In the initial screen, I identified five C. elegans DEG/ENaCs subunits that can form proton-sensitive homomeric channels when expressed in vitro in Xenopus oocytes. These could be further clustered into two …
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