Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 164 for “"cell models"”.
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Electrochemical Focal Hypoxia for Cell Models
… limited energy storage. Currently common hypoxia models such as low oxygen incubators, hypoxia chambers and chemical hypoxia have two major flaws: no spatial control and long equilibration time. It is not possible to induce hypoxia focally such that these approaches have very limited …
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Stimulus-Section Coupling in Endocrine Cell Models
… Stimulus-secretion coupling in hormone secreting cells is a complex system of pathways that link activation of cellular processes by i.e. nutrients to the release of hormone. Stimulus-secretion coupling in the insulin secreting beta-cell is intensely researched to improve our understanding of type …
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Mechanisms of toxicity in cell models of FSHD
… ectopic DUX4 expression is highly toxic in human cells. In my thesis work, using a new cell model with regulated expression of DUX4, I found that expression of DUX4 leads to the stabilization of normally rapidly turned-over mRNAs including cMYC, whose overexpression is associated with …
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Periodic cell models of flow through porous media
Model problems are analyzed to study the microscopic flow within porous media. In Part 1, the primary focus is on the flow near the surface of a porous body. The idealized system consists of two-dimensional media of infinite and semi-infinite periodic lattices of cylindrical inclusions. The …
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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
Prostate cancer (CaP) is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths in American men. Despite earlier detection, CaP continues to be fatal in ~10% of cases and better treatments for patients with advanced disease are desperately needed. Understanding …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… the effects of n-3 PUFA in porcine IPEC-J2 cell line under (LPS) stress conditions underpinning pig nutrition, combining the state-of-the-art cell-based assays and bioinformatic analysis. The second part of our study was directed towards establishing a primary intestinal epithelial cell …
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The healthy effects of L. barbarum on in vitro cell models
… characterized by the over proliferation of the cells. Epidemiological studies indicate that about 30-40% types of cancers are directly or indirectly linked to improper diet and related factors. Morover, several reports demonstrate an association between intake of fruits and vegetables and …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… study aimed to utilise induced pluripotent stem cell (iPSC) models of TAD to analyse genetic variants from the 100,000 Genomes Project by determining causality, disease mechanisms and identifying drug targets. We focused on three Tier One variants, protein truncating in known aortopathy-related …
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Effects of oxidative stress and neuroprotection in apoptosis in neuronal cell models
The PC12 and SH-SY5Y cell models have been proposed as potentially realistic models to investigate neuronal cell toxicity. The effects of oxidative stress (OS) caused by both H2O2 and Aβ on both cell models were assessed by several methods. Cell toxicity was quantitated by measuring cell viability …
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Comparative studies of brain developmental timing and progression using 3D stem cell models
… We used self-organising brain organoid models, derived from stem cells of different relevant species to establish paradigms for comparative studies in brain development, and understand aspects of human specific brain development in vitro. In order to make fair comparisons between brain …
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Characterisation of PACAP-responsive receptor pharmacology and expression in cell models and the spinal cord
… pharmacology and translate these findings from cell model systems to human spinal cord tissue. Chapter 3 investigated the activation of multiple signalling pathways by all endogenous agonists at all human PACAP-responsive receptor subtypes, including an N-terminal PAC1 receptor splice variant. …
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Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development
… neurons with the use of induced pluripotent stem cells (iPSCs) derived from RTT patient skin samples. We generated a variety of monolayer and 3D neuronal models and found that RTT phenotypes are present at the earliest stages of brain development including neuroepithelial expansion, neural …
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Mitochondrial Stress Signals Induce a Drug Tolerant Persister Phenotype in Triple Negative Breast Cancer Cell Models
… been a long-standing challenge. Over time cancer cells develop the ability to survive these cytotoxic insults, usually by undergoing genetic mutations leading to drug resistance. In recent years, a distinct pathway involving formation of drug tolerant persister (DTP) cancer cells has been …
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Novel cell models for the study of spinocerebellar ataxia type 7 pathogenesis and therapy in a South African patient cohort
… regulation through association with cellular histone acetylation complexes, and several studies have highlighted the role of transcriptional dysregulation, caused by the presence of mutant Ataxin-7, in the neuronal dysfunction that precedes the onset of disease symptoms.This study …
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Studies on the synergic activity of a three-drug cocktail active against cisplatin-resistant human leukemia and carcinoma cells
… complexes previously reported against T-leukemia cells (Pivetta et al.,Talanta, 2013), my research project was aimed at (1) extending the studies of CDDP-Cu(II)-phen combinations as such, as well as with the addition of a third drug component; (2) determining the potential degree of selectivity of …
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Layout Synthesis of Nmos Gate-Cells
The NMOS Gate-Cell, a regular structure that supports gate level implementations of random logic is introduced. It is an extension of the Weinberger array, where allowing input/output terminals on all four edges resulted in an improved interconnect flexibility. Intercell routing is allowed to …
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Functional analysis of amyotrophic lateral sclerosis mutations using Drosophila cell culture models
… G298S, Q331K, M337V) using Drosophila S2R+ cell models. This project combines molecular biology, high-throughput genetic screening, and transcriptomics analysis to identify potential therapeutic targets of ALS. Transient Drosophila S2R+ cell models expressing wild-type or mutant forms of the …
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Roles of Phospholipase A/Acyltransferase Enzymes in Membrane Remodelling and Organelle Degradation
… in membrane structure and properties require cells to adjust their membrane lipid composition accordingly. One of the ways cells can rapidly generate a diverse repertoire of membrane lipids is through remodelling the fatty acid tails of phospholipids. This process is coordinated by …
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