Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"cd38"”.
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Deficiency in Parkinson's Disease risk gene CD38 as it relates to glial function: dysregulation of astrocyte genes and bioenergetics as a result of CD38 deficiency
… polymorphisms (SNPs) in the loci for CD38 that cause reduced gene expression are consistently identified as increasing risk. The cluster of differentiation 38 (CD38) protein serves two major roles: one as a receptor for immunological response and a second as an ectoenzyme that …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… that hybrid EM murine tumors are enriched in CD38, an immunesuppressive molecule associated with worse clinical outcomes in liquid malignancies but relatively understudied in solid tumors such as breast cancers. Hence, we sought to investigate the role of CD38 in hybrid EM-driven metastasis …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… its therapeutic efficacy. The leukocyte antigen CD38 is an ectoenzyme and receptor that propels MAPK signaling and ATRA-induced differentiation when overexpressed. CD38 enzymatic activity regulates calcium flux and NAD metabolism while its receptor functions drive phosphorylation of ERK, c-Cbl, …
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The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
… (PARPs). The cyclic (ADP)-ribose synthase, CD38, is the primary NAD’ase in cells and has historically been regarded as an important cell surface molecule in cells of hematopoietic lineage. The work presented herein is focused on the role of CD38 in regulating prostate cancer (PCa) cell …
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ZFP36 proteins and mRNA targets in B cell malignancies
… have important roles in B cell biology, BCL2 and CD38 mRNAs. BCL2 is an anti-apoptotic protein with key roles in cell survival and carcinogenesis; CD38 is a membrane protein differentially expressed in B cells and with a prognostic value in B chronic lymphocytic leukaemia (B-CLL), patients …
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Vývoj vybraných CD znaků a jejich role ve fylogenezi imunitního systému člověka
… human, namely CD19, CD20, CD21, CD24, CD27 and CD38 molecules. In addition, nucleotide and amino acid sequences of these molecules were compared using in silico approach. Bioinformatic databases of sequences of selected molecules at DNA, mRNA and protein level, such as GeneBank, NCBI BLAST, …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… and protein levels of the potent NAD+ hydrolase CD38 are diminished in prostate cancer. CD38 protein levels were high in normal prostate cells and low in cancer prostate cancer cell lines, which correlated with high NAD<super>+</super> levels in the tumorigenic cells. This indicates that high …
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Strategien zur Verstärkung der antikörpervermittelten Effektorzellaktivierung beim Multiplen Myelom
… einen wichtigen Beitrag zur Effektivität des CD38-Antikörpers Daratumumab. Im Rahmen dieser Arbeit wurden Strategien zur Verstärkung dieser Wirkmechanismen entwickelt, um die CD38-gerichtete Myelomtherapie zu verbessern. Durch Modifikation der Fc-Domäne (Fc-Engineering) sollte eine optimierte …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… negative selection of human cord blood Lin-CD34+CD38-CD45RA- cells for PTPRS expression yielded a 15-fold enrichment for human long term HSCs compared to Lin-CD34+CD38-CD45RA- cells or Lin-CD34+CD38-CD45RA- PTPRS+ cells. These data suggest that PTPRS regulates HSC repopulating capacity via …
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From structural dynamics to drug repurposing: computational approaches in the context of precision medicine
… the enzyme Cluster of Differentiation 38 (CD38), which is implicated in aggressive malignancies like myeloid leukemia, currently lacks small-molecule inhibitors, severely limiting the possibility of effective targeted therapies. In this thesis, a combination of molecular docking and …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
… cellular cytotoxicity (ADCC) of CD34+CD38- CML cells in vitro. In Article III, the function of IL1RAP in normal hematopoeisis and in CML was investigated. Mice lacking Il1rap displayed lower myeloid steady-state cell counts. Overexpression of IL1RAP in cord blood cells, followed by …
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biological treatment options of multiple myeloma
… receptors. Daratumumab is a therapy that targets CD38, the primary receptor found on normal plasma cells and multiple myeloma cells. Alternatively, another potential target on the surface of cells is SLAMF7, sometimes referred to as CS1, which is specifically recognized by Elotuzumab. Both kinds …
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Integrin α2 and Akt in early hematopoiesis
… expressed in cord blood-derived CD34+CD38-CD90+ in vivo long-term repopulating cells, demonstrated by 24-week limiting-dilution xenotransplantations using immunodeficient mice. Second, we revealed that integrin α2, which is a marker for megakaryoctyes and platelets, was not expressed …
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
… CD180 and other prognostic markers such as CD38 and ZAP70 displayed any correlation with the known cytogenetic aberrations:TP53 and DLEU1. Our results suggested that CLL cells with DLEU1 deletion are characterised by the negative expression of both, CD180 and CD38, and this might have a …
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Oxytocin and Genetic Links with Eating Behaviours and Relevant Endophenotypes
… on this work by analyzing SNPs of the LNPEP, CD38, and OXTG genes. Additionally, sex differences were also examined. A pre-existing data set consisting of 460 healthy volunteers was used in the study. A series of two-way MANOVAs were employed and results indicated nonsignificant main effects …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… transitional B cells can be identified as CD24++CD38++CD10+ cells and attempts have been made to segregate them into subsets based on the expression level of CD24 and CD38. Here we have identified 2 subsets of human transitional B cells (CD20+CD27-CD10+) based on the differential expression of …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… polymerase (PARP), cADP-ribose synthase (CD38) or SIRT inhibitors in HG/PA-induced cell death. Pharmacologic inhibitors of PARP such as 3-AB and INH2BP or reduction of PARP using siRNA did not protect HG/PA-induced viability reduction and HG/PA-induced DNA fragmentation. Knock down or …
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Immunosenescence in B Cells: A Study on Changes in Immunoregulator Expression and Metabolism With Age
… expression of the defining markers CD27 and CD38. Aged ASCs also expressed lower levels of B and T Lymphocyte attenuator (BTLA) on their surface. Expression of BTLA inversely correlated with age and appeared to be linked to shifting the nature of the response from IgM to IgG. High BTLA …
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Differenzierungsabhängige Modulation der Zytokin- und Chemokinexpression bei humanen myeloischen Zell-Linien
… CD11c, CD13, CD14, CD15, CD18, CD19, CD33, CD34, CD38, CD40, CD41, CD42b, CD45, CD45RA, CD45RO, CD61, CD69, CD71, CD95, CD154, Glykophorin A, HLA-DR), der Zytochemie (Myeloperoxidase, Lysozym, unspezifische Esterase) und der Zellmorphologie untersucht. Es zeigte sich, daß sich das Zytokin- und …
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