Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"cccDNA"”.
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Biological Functions of Intracellular Hepatitis B e Antigen
… we found that the nuclear p22 can bind to cccDNA minichromosome and affects cccDNA maintenance and/or transcription. Thus, our results indicate that there is a novel ER sorting mechanism for the distribution of the intracellular and secretory HBeAg, and the intracellular HBeAg may …
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Hepatitis B Virion and cccDNA Formation in Primary Tupaia Hepatocytes and Human Hepatoma Cell Lines upon HBV Genome Transduction with Replication-defective Adenovirus Vectors and in vivo Infection of Tupaias
Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is a hepatotropic DNA-containing virus that replicates via reverse transcription. Because of its narrow host range there is as yet no feasible small animal system for HBV infection. Some evidence suggests that tree shrews …
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
… and after treatment. NA had little effect on HBV cccDNA level and persistence of mRNA in PBMC. The study on HBV genetic features in CHB carriers with acute-on-chronic liver failure (ACLF) revealed the frequent immune escape mutations with clusters of surface gene variants possibly associated with …
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Genomic profiling and perturbation of Hepatitis B virus infection
… degradation of the long-lived, episomal HBV cccDNA, resulting in >1 log-fold reductions in cccDNA in both constitutively HBV-producing and newly HBV infected cells. Overall, this work takes steps toward both elucidating HBV biology, and accelerating the path toward novel treatments for this …
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Relationship between Hepatitis B Virus Core Particles and Intracellular Motility
… in maintaining covalently closed circular (cccDNA) pool in the nucleus. Transport of HBV core particles in host cytoplasm is important for HBV life cycle but the mechanism is not elucidated yet. In this study, the change of the cytoskeletal organization and organelle distribution was …
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Methods and applications of using DNA-cleaving DNAzymes to cleave double-stranded DNA
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01