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Showing 1 to 20 of 32 for “"calcium ATPase"”.

  1. Targeting the calcium ATPase to the endoplasmic reticulum

    Watson, Helen RachelUniversity of Southampton2009

    The sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps calcium from the<br/>cytoplasm into the lumen of the endoplasmic or sarcoplasmic reticulum (ER/SR), removing<br/>excess Ca2+ from the cytoplasm and replenishing ER/SR Ca2+ stores. SERCA is located in<br/>both the ER and the ER-Golgi …

    soton Repository record

  2. Structural studies on the plant plasma membrane calcium-ATPase

    Basu, SwatiUniversity of Illinois at Urbana-Champaign2011

    The plasma membrane Ca$\sp{2+}$-ATPase is a ubiquitous membrane protein that mediates the active transport of calcium out of the cytoplasm into the cell exterior. In plant cells it is believed to play a major regulatory role in signal transduction by helping to maintain a large gradient of calcium …

    uiuc Repository record

  3. The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels

    Fenech, MelissaThe University of Western Ontario2019

    … acinar cell exocytosis requires precise calcium (Ca2+) signals. When cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and …

    uwo Repository record

  4. Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium

    Khan, KinzaUniversity of Wolverhampton2022

    … including atherosclerosis. Plasma Membrane Calcium ATPase 4 (PMCA4) belongs to a family of transmembrane ion transporters that extrude calcium from the cytosol to the extracellular environment (Strehler, 2015). They are the only high-affinity Ca2+ extrusion system in mammalian cells encoded …

    wlv Repository record

  5. Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis

    Baggott, Rhiannon RebeccaUniversity of Wolverhampton2014

    … One possibility is the plasma membrane calcium ATPases (PMCAs). These high affinity calcium extrusion pumps have been shown to interact with calcineurin in mammalian cells and cardiomyocytes and down-regulate the calcineurin/NFAT pathway. This is hypothesised to be due to the interaction …

    wlv Repository record

  6. Untersuchung der funktionellen Interaktion zwischen der sarkolemmalen Calcium-ATPase und der neuronalen NO-Synthase

    Telkamp, MyriamUniversität Würzburg

    Die Plasmamembrancalcium-ATPase (PMCA) konnte als Interaktionspartner und Inhibitor der neuronalen NO-Synthase (nNOS) in Kardiomyozyten identifiziert werden. PMCA und nNO-Synthase kommen in Caveolae von Kardiomyocyten vor. Humane PMCA4b überexprimierende Rattenherzen zeigen ex vivo eine signifikant …

    wurz-thes Repository record

  7. Investigating the expression of plasma membrane calcium ATPase (PMCA) in patient-derived glioblastoma cultures

    Najafi, ShervinUniversity of Wolverhampton2026

    … this thesis explores the role of Plasma Membrane Calcium ATPases (PMCAs) in the pathology of glioblastoma, with a specific focus on isoforms PMCA1, PMCA2, and PMCA4. Patient-derived glioblastoma cultures and biopsy samples were employed to investigate PMCA expression patterns at both the …

    wlv Repository record

  8. A NOVEL SELECTIVE INHIBITOR FOR PLASMA MEMBRANE CALCIUM ATPase 4 IMPROVES VEGF-MEDIATED ANGIOGENESIS

    Kurusamy, Sathishkumar2017

    … shown a novel role for the plasma membrane calcium ATPase 4 (PMCA4) protein as a negative regulator of VEGF-induced angiogenesis via interaction with calcineurin. The recent identification of aurintricarboxylic acid (ATA) as a selective inhibitor of PMCA4 prompted us to hypothesise that …

    wlv Repository record

  9. Mutations in Phospholamban Alter the Structure and Function of the Calcium ATPase Regulatory Complex

    Abrol, Neha2016

    … plays an important role in regulation of cardiac calcium handling and contractility. PLB exists as a homopentamer in the membrane, which upon deoligomerization into active monomers reversibly inhibits sarco/endoplasmic reticulum calcium ATPase (SERCA). Mutations in PLB that change the PLB …

    loyola-thes Repository record

  10. Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells

    Immanuel, Reshma Naomi RanjitUniversity of Wolverhampton2021

    … reported a negative role for the Plasma Membrane Calcium ATPase 4 (PMCA4) protein in endothelial cells, acting via inhibition of the pro-angiogenic calcineurin/NFAT signalling pathway. However, we hypothesise that other intracellular pathways might be regulated by PMCA4 in endothelial cells during …

    wlv Repository record

  11. PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION

    Lv, Yuanzhao2018

    … Ca2+ homeostasis, the L-type Ca2+ channels (calcium channel blockers). Other agents, like beta blockers, indirectly target various elements, including sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) and ryanodine receptors (RyRs). However, there are no pharmacological agents that directly and …

    siu-theses Repository record

  12. The Role of Membrane Lipid Composition on Sarco(endo)plasmic Reticulum Calcium ATPase Function in Rat Soleus Muscle

    Trojanowski, Natalie S.Brock University2015

    Sarco(endo)plasmic reticulum calcium ATPase (SERCA) is a transmembrane protein whose function is regulated by its immediate lipid environment (annulus). The composition of the annulus is currently unknown or it’s susceptibility to a high saturated fat diet (HSFD). Furthermore it is uncertain if …

    brock Repository record

  13. Magnesium Regulation of Calcium in Essential Hypertension

    Gordon, Elaine Pringle2019

    … and its impact on the functional ability of the calcium ATPase. Rats were fed either a magnesium-deficient or a magnesium-sufficient diet for 10 weeks, after which the calcium ATPase activity was measured in intact red blood cells (RBC). Free intracellular calcium [Ca<sup>2+</sup>]i accumulation …

    odu Repository record

  14. Veränderungen der Calcium-Homöostase als mögliche Ursache einer linksventrikulären Funktionsstörung im humanen "hibernating myocardium"

    Nef, Holger Markus

    … um die Bedeutung einer intakten intrazellulären Calcium-Homöostase für eine regelrechte myokardiale Kontraktilität die Hypothese untersucht werden, ob diese im HHM möglicherweise gestört ist. Ursache für eine Störung des Calciumhaushaltes könnte eine ver-änderte Expression der …

    freiburg-diss Repository record

  15. Mechanisms of Calcium Buffering and Aging in Neurons: Testing the Limits of Homeostasis

    Pottorf, William James, II

    <p>Intracellular calcium ([Ca<sup>2+</sup>]i) is an ubiquitous second messenger that integrates multiple and diverse neuronal pathways that include development and maturation, gene expression, synaptic plasticity, transmitter release, excitability, and even cell death. Upon neuronal excitation the …

    loma-linda Repository record

  16. Einfluss von vascular endothelial growth factor, transforming growth factor-beta-1, Interleukin-6, atrial natriuretic beptide, brain natriuretic peptide und Cortisol auf die Gen-Expression des menschlichen Herzmuskels in vitro

    Fliedner, Anselm

    … sezerniert werden, sarkoplasmatische Retikulum-Calcium-ATPase (SERCA) und Natrium-Calcium-Exchanger (NCX), zwei Proteine, die wesentlich an der Calcium-Homöostase des Myokards beteiligt sind, c-fos, einem immediate early gene, Calcineurin A, einer Calcium/Calmodulin abhängigen Phosphatase, die …

    freiburg-diss Repository record

  17. Kontraktilität des isolierten menschlichen Kardiomyozyten. Einfluß von Calcium, Isoproterenol, Stimulationsfrequenz, Stimulationspause und Thapsigargin.

    Kamenzin, Susanne

    … Funktion des Kardiomyozyten wird durch die Calciumhomöostase bestimmt und kann experimentell zusätzlich zur Kraft-Frequenz-Beziehung (KFB) anhand der Post-Pausen-Beziehung (PPB) untersucht werden. Während die KFB eher die Funktion des sarkoplasmatischen Retikulums (SR) prüft, spiegelt die …

    freiburg-diss Repository record

  18. Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle

    Guo, Jingxuan2026

    … There was also profound dysregulation of calcium handling; studies with drug probes revealed that this was caused by excessive calcium intake rather than either sarcoplasmic reticulum calcium ATPase dysfunction or defective buffering of calcium by cardiac myofilaments. These studies …

    wustl Repository record

  19. Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure

    Allen, Emily E.Virginia Tech2002

    … for the fatigue. During skeletal muscle fatigue, calcium handling is altered. Thus, the fatigue associated with congestive heart failure could be attributed to altered calcium handling. The main proteins involved in calcium release are the ryanodine receptor (RyR) and the dihydropyridine receptor …

    vt Repository record

  20. Regulation des Tonus glatter Gefäßmuskelzellen bei die hPMCA4b überexprimierenden Mäusen

    Knauer, SebastianUniversität Würzburg

    … mit der Rolle der sarkolemmalen Kalzium-ATPase PMCA (plasma membrane calmodulin-dependent calcium ATPase), die Kalziumionen aus der Zelle pumpt. Insbesondere ihre physiologische Relevanz neben dem sehr effektiven Na+/Ca2+-Austauscher ist spekulativ. Transgene Mäuse, die die humane Isoform …

    wurz-thes Repository record

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