Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"cPLA2"”.
-
Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
… studies from our laboratory showed that cPLA2α may be responsible for approximately 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory cytokines. …
-
Role of Ceramide-1-Phosphate as a Specific and Potent Activator of Group IVA Cytosolic Phospholipase A2 Alpha
… acid by group IVA cytosolic phospholipase A2 α (cPLA2α) is the initial rate limiting step for the production of eicosonoids in response to inflammatory mediators. Previous findings from our laboratory have demonstrated that cPLA2α is directly activated by the emerging bioactive sphingolipid, …
-
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… neuronal cell death. Cytosolic phospholipase A2 (cPLA2) belongs to a family of phospholipases that act as the principle producers of arachidonic acid (AA) in cells. During the process of inflammation, AA released from phospholipids is metabolized by cyclooxygenase-1[slash]2 (COX1[slash]2) and …
-
Phospholipase A 2 in der Parvovirus MVMp induzierten Zelllyse
… Enzyme, die in sekretorische sPLA2, zytosolische cPLA2 und Ca2+-unabhängige iPLA2 unterteilt werden, aus den folgenden Gründen für diesen Zusammenhang von Bedeutung sein könnten. Zum einen sind sie als Phospholipidhydrolasen, neben der Produktion von Lipidsignalmediatoren, auch als wichtige …
-
Mouse modifiers of intestinal tumorigenesis
… lacking group IV cytosolic phospholipase a2 (cPLA2). Crossing ApcMin into this background produces an 83% reduction in tumor number in ApcMin, cPLA2 -/- homozygotes, suggesting that cPLA2 expression promotes tumorigenesis, most likely via the production of arachidonic acid for downstream …
-
Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… of the AA cascade by the following enzymes: cPLA2: is expressed in resting Kupffer cells; cPLA2 expression and phosphorylation is increased by LPS, dexamethasone suppresses the LPS effect, localization in membrane fraction. COX-1: is expressed in resting Kupffer cells; COX-1 expression is not …
-
Caracterización de las vías de la fosfolipasa A_2 en procesos de neurodegeneración inducidos por estrés oxidativo en la retina bovina
… fosfolipasa A2 (PLA2): la isoforma citosólica (cPLA2), la isoforma independiente de calcio (iPLA2) y la isoforma secretoria (sPLA2), durante la toxicidad retiniana inducida por Fe2+. También analizamos las implicancias de las diferentes PLA2s en la regulación de la ciclooxigenasa (COX)-2, el …
-
L' effet polymorphisme d'un seul nucléotide (SNP) de la PLA2 de groupe IVC (cPLA2y) sur son activité enzymatique
… moins étudiée, la phospholipase de groupe IVC (cPLA2γ), fut découverte en 1998 par deux différents groupes de chercheurs soit Underwood et al., 1998 and Pickard et al., 1999. Toutefois, le papier de Pickard et al. démontra un polymorphisme d'un seul nucléotide (SNP) causant une mutation qui …
-
Biomarkers of oxidative stress in models of schizophrenia.
… cell lines was examined, and the basal level of cPLA2 activity was found to be comparable in the lymphoblastoid and IMR-32 cells, but significantly lower than that measured in the U937 cells. Supplementation of the U937 cell line with EPA caused a significant decrease (p < 0.05) in cPLA2 activity …
-
Regulación de la migración celular en la retina por ceramida-1-fosfato
… y activación de la fosfolipasa A2 citosólica (cPLA2), que interviene en la síntesis de prostaglandinas. Para promover la migración, se ha propuesto que la C1P activa un receptor extracelular específico (parcialmente identificado). Trabajos previos de nuestro laboratorio demuestran que la …
-
Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… LTD4 via the CysLT1R can activate the enzyme cPLA2-alpha. This enzyme releases arachidonic acid, the precursor of CysLTs, from the cell membranes, upon activation. One major regulatory mechanism of GPCRs is the internalization from cell membrane upon activation. We demonstrate how LTD4 mainly …
-
Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
… in eicosanoid production, it is possible that cPLA2α might play a central role in the development of Ang II-induced hypertension. To test this hypothesis, we investigated the effect of Ang II infusion for 13 days by micro-osmotic pumps (700 ng/kg/min), on systolic blood pressure and associated …
-
In Vitro Modeling of the Blood–Retinal Barrier: Investigating the Role of Pericyte-Like Adipose-Derived Mesenchymal Stem Cells and the Application of an iBRB on-a-Chip System [Modello in vitro di barriera emato-retinica umana: effetti delle cellule staminali mesenchimali adipose differenziate verso un fenotipo pericitico e applicazione di un sistema iBRB on-a-chip]
… l’attivazione dell’asse infiammatorio ERK1/2-cPLA2-COX-2. Parallelamente, hanno potenziato la risposta antiossidante aumentando la traslocazione nucleare di Nrf2 e promuovendo la sovraregolazione di HO-1. Per integrare i risultati ottenuti nei modelli 2D, è stato utilizzato un sistema …
-
Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation
… p65, and Cox-1 protein levels, MAPK p38 and cPLA2 phosphorylation and PGE2 release, and reversed LPS-induced decreases in TGF-β1 and IL-4. Moreover, acetate treatment reduced basal levels of IL-6, phosphorylated ERK1/2 and NF-κB p65 at serine 536, sPLA2 IIA and PLCβ1. Acetate treatment also …
-
The Signaling Pathway of Oxysterol Induced Apoptosis in Chinese Hamster Ovary (CHO)-K1 Cells.
… apoptotic response to 25-OHC in CHO-K1 cells. CPLA2ûmediated liberation of AA leads to the formation of a cyclooxygenase product, probably a prostaglandin, which activates the transcription factor PPARγ and induces apoptosis. We also examined the execution phase of the apoptotic pathway in …
-
Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon
Intestinal Mesenchymal stromal cells (fibroblasts, myofibroblasts and their progenitors) have recently emerged as key players in the interplay between the microbiota and professional immune cells under homeostasis and chronic inflammation. Initiation of microbial interactions with host cells, …