Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"brain pathology"”.
-
Testing the Gliocentric Hypothesis of Brain Pathology
… sensitivity was carried out via live imaging of brain slice and optic nerve preparations from transgenic mice which specifically expressed GFP in either astrocytes or oligodendrocytes. Ischaemia was modelled using oxygen glucose deprivation (OGD). It was determined that astrocytes display …
-
Unravelling the mechanisms behind brain pathology in Leigh syndrome
Contains fulltext : 332887.pdf (Publisher’s version ) (Closed access)
-
Multi-omics mapping of the stress load on cell-specific glucocorticoid-dependent cascades in Tau brain pathology
Το χρόνιο ψυχολογικό στρες και τα υψηλά επίπεδα γλυκοκορτικοειδών (GC) αποτελούν εκλυτικούς παράγοντες της εγκεφαλικής παθολογίας στη νόσο του Αλτσχάιμερ, ωστόσο οι μοριακοί μηχανισμοί που διαμεσολαβούν σε αυτή την επίδραση του στρες/GC σε διαφορετικούς πληθυσμούς εγκεφαλικών κυττάρων παραμένουν …
-
Cognitive resilience is mediated by the MEF2 network in mice and humans
… function even in the presence of extensive brain pathology. The molecular mechanisms that govern this neuro-protected state remain unknown, but individuals that exhibit cognitive resilience (CgR) represent a unique source of insight into potential therapies that could preserve brain function …
-
Functional Activation Patterns in Pediatric-Onset Multiple Selerosis: Does Physical Activity Play a Role in the Maintenance of Working Memory
… multiple sclerosis (POMS), despite significant brain pathology, suggesting that mechanisms facilitating adaptation to pathology may be occurring. We examined executive control processing in 20 cognitively-preserved POMS patients and 20 age and sex-matched healthy controls, using a working memory …
-
Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
<p>Traumatic brain injuries (TBIs) are a common form of head injury, with mild TBIs (mTBIs) making up 75-90% of the TBI severity scale. It’s been suggested that repetitive mild TBIs (rmTBIs) may enhance effects of Alzheimer’s Disease (AD). With dementia linking TBI and AD together, we investigated …
-
Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… and intracellular neurofibrillary tangles. Brain pathology is reflected in cerebrospinal fluid (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific …
-
Devices for Extracellular Detection of Astrocytic Infraslow Electrophysiological Biomarkers
… with neurons and thus play a crucial role in brain information processing. This discovery, long overlooked due to the dominance of neuronal research, has prompted a significant reconsideration of their importance in understanding brain function. These cells are known from intracellular studies …
-
DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
… the molecular mechanisms underlying healthy brain ageing in the exceptionally long-lived naked mole rat (NMR) and the role of the DNA damage response in the pathogenesis of Huntington's disease (HD). Multi-omic analyses of NMR brain ageing revealed a lack of a canonical ageing signature in …
-
Vascular changes in Alzheimer’s disease and other types of dementia in the retina of human and animal
… a complex condition which manifests within the brain causing loss of brain function and resultant cognitive decline. The retina is closely related to the brain and it has been proposed that the retina may be adversely affected in Alzheimer’s disease (AD). If AD-associated pathologies can be …
-
The microbiome-gut-brain axis in preclinical alpha-synuclein models of Parkinson's disease
… degeneration of the nigrostriatal pathway in the brain, causing motor dysfunction, and the build-up of α-synuclein protein fibrils throughout several brain regions. Many PD patients report a number of gastrointestinal (GI) symptoms some of which can precede motor symptoms. α-synuclein is detected …
-
The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice
… is a fatal cognitive disorder with proteinaceous brain deposits, neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss. AD is a multifactorial disease, and lifestyle factors, including diet, are likely associated with the development of AD pathology. Since obesity and …
-
Developing Tools to Physically Magnify Biological Substrates for Clinical Applications
… enhanced nanoscale resolution of clinical pathology and liquid biopsy samples using conventional confocal microscopes. Biology is based on nanoscale building blocks, biomolecules, which interact over nanoscale distances. Diseases, especially in their earliest stages, are associated with …
-
Developing Deep-Learning Methods for Diagnosis and Prognosis of Pediatric Progressive Diseases Using Modern Imaging Techniques
… age. 2) Presents the first work to look at whole-brain network to automatically distinguish TSC brain structural pathology from normal cases using a 3DCNN model.</p> <p><strong>Conclusions</strong>. The study findings indicate that deep neural networks tackle the problem of early prediction of …
-
A Study of alpha-Synuclein, Parkin and TDP-43 ; Proteins Implicated in Neurodegenerative Disease.
… inclusions called Lewy bodies found in the brain in PD contain alphaS. Rare inherited forms of early-onset PD are caused by autosomal dominant mutations in alphaS or by autosomal recessive mutations in parkin, a 53kDa E3 ubiquitin ligase. alphaS and parkin have been reported to interact …
-
Retinal thickness in adults with Down's syndrome: Relationship with age, cognition and dementia
… event in the pathogenesis of AD. In DS, AD neuropathology is universally seen in the brain from the fourth decade. Identifying biomarkers are essential to the evaluation of future treatment trials. The retina has been shown to experience changes in patients with AD, such as retinal thinning, …
-
The Host Response to Venezuelan Equine Encephalitis Virus
… infection with complete viral clearance from the brain in C57BL/6 mice (2) lethal infection in C3H/HeN mice and (3) persistent viral infection of the brain in α/β T-cell receptor deficient (TCR KO) mice. All three strains display a similar viral kinetic and brain pathology. Further comparison of …
-
Interstitial Fluid Flow Magnitude and Its Effects on Glioblastoma Invasion
… flow is a complex and dynamic process in the brain, taking place at the macro- and microscopic level. Interstitial fluid in particular flows throughout the interstitial spaces within the tissue, interacting with cells and the extracellular matrix. We are coming to find that this interstitial …
-
Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
… disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy individuals, …
Page 1 of 2