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Showing 1 to 20 of 101 for “"bile acids"”.
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Liquid Crystal-Based Biosensors for the Detection of Bile Acids
Bile acids are physiologically important metabolites, which are synthesized in liver as the end products of cholesterol metabolism and then secreted into intestine. They are amphiphilic molecules which play a critical role in the digestion and absorption of fats and fat-soluble vitamins through …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
The bile acid receptor, also known as farnesoid X receptor (FXR), is essential for feedback regulation of bile acid synthesis. Bile acids are required for the proper absorption of dietary lipids, including fat-soluble vitamins; however, some bacterial metabolites of bile acids have been shown to …
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THE BIOTRANSFORMATION OF BILE ACIDS BY A COMMON MEMBER OF THE BISON GUT MICROBIOME
Bacterial biotransformation of bile acids (BAs) is increasingly recognized to play an important role in the health and disease of the host. Bile acid-modifying bacteria participate in the production of a large number of secondary BAs (2 BAs) with known and yet to be discovered activities. In the …
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Mechanisms into the development of fatty liver disease: role of bile acids, Betaine and MHY908
… remains elusive, though it is known free fatty acids such as palmitate promote liver injury. Therefore, there is a pressing need to find a potent therapeutic approach for NAFLD. Firstly, this study aimed to investigate the lipotoxicity and mitochondrial dysfunction attributable to palmitic acid. …
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Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria
Bile acids are C24 steroids that are derived in the liver from cholesterol and secreted into the intestinal lumen to aid in emulsification of dietary lipids and lipid-soluble vitamins. The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The …
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Chemical investigations into the physiology of bile acid skeletons
Bile acids are a class of surfactants that facilitate the digestion of dietary lipids and fat soluble vitamins in the intestines of vertebrates. Since they are the end products of cholesterol metabolism, bile acids biosynthesis is the major pathway to remove excess of cholesterol, which is another …
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ΚΙΝΗΤΙΚΗ ΜΕΛΕΤΗ ΚΑΙ ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΕΝΖΥΜΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΧΟΛΙΚΩΝ ΟΞΕΩΝ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ
… KINETIC STUDY OF ENZYMATIC SYSTEMS USING BILE ACIDS AS SUBSTRATES AND ITS APPLICATION FOR THE DETERMINATION OF BILE ACIDS ARE BASED ON THE SPECIFIC OXIDATION OF THEIR HYDROXYL GROUPS BY NICOTINAMIDE ADENINE DINUCLEOTIDE (B-NAD+) OR BY B-NADP+ IN THE PRESENCE OF HYDROXYSTEROID …
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Quantitative und qualitative Analyse der Derivate der Ursodeoxycholsäure im Urin gesunder Probanden
… following fractions were obtained: unconjugated bile acids, nonamidated bile acid glucosides and N-acetyl-glucosaminides (fraction 1), glycine- or taurine-conjugated bile acids and glycine- or taurine-conjugated bile acid glucosides and N-acetyl-glucosaminides (fraction 2), nonamidated and …
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COMMUNITY STRUCTURES OF GUT MICROBIOME UNDER DIFFERENT DIETS IN ANGUS BEEF CATTLE
… the production of VFA and the composition of bile acids in beef cattle. We used rectum microbiota as a baseline and examined the microbiome in rumen and jejunum by16S-seq, together with quantifications of VFAs, lactate, and bile acids under grass-feeding and grain-feeding. We found that …
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The Role of OSTα-OSTβ and Bile Acid Transport in Intestinal Disorders Aand Metabolic Disease
Over the past 60 years, the study of bile acids has evolved from an esoteric source of fascination for chemists to becoming a field of enormous potential and discovery. Among their important physiological properties, bile acids function as critical detergents to solubilize biliary and dietary …
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Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities have been synthesized and characterized. Attempts toward oxa-Michael …
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Adding Upstream Sequence and a Downstream Reporter to the Bile Acid Inducible Promoter of <I>CLOSTRIDIUM scindens</I> VPI 12708
Bile acids in the small intestines of animals serve to breakdown fats and fatsoluble vitamins. Most of the bile acids are reabsorbed into the enterohepatic circulation, but approximately five percent of these bile acids pass into the large intestine. These bile acids are swiftly deconjugated by the …
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ENZYMOLOGY AND MOLECULAR BIOLOGY OF BILE ACID 7alpha- AND 7beta- DEHYDROXYLATION BY THE INTESTINAL BACTERIA CLOSTRIDIUM SCINDENS AND CLOSTRIDIUM HYLEMONAE
… microbiome, "the second human genome project". Bile acids, endogenously produced by the host liver, represent both a strong selective pressure for potential colonizers, aswell as substrates for microbial metabolism. Indeed, microbes have evolved enzymes to deconjugate bile salts, epimerize bile …
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Taurocholat-Transport in isolierten proximalen Tubuluszellen der Ratte : Einfluss einer extrahepatischen Cholestase
… the non-protein bound fractions of plasma bile acids are filtered in the glomeruli. The bile acids reaching the tubular fluid are nearly completely reabsorbed by the apical sodium-dependent bile salt transporter (asbt). Hence, with normal conditions, urinary excretion of bile acids is …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… functions of SHP, maintaining cholesterol and bile acid levels by negative feedback regulation of hepatic conversion of cholesterol to bile acids is well established. Cholesterol is essential in many biological activities in mammalian cells. Conversion of hepatic cholesterol into bile acids is …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
Bile acids are synthesized from cholesterol in hepatocytes and secreted into bile. After a meal, bile acids are released from the gallbladder into the small intestine to facilitate the digestion and absorption of dietary fats and lipid soluble vitamins. Most bile acids in the intestine are …
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Understanding the molecular mechanism through which aspirated bile triggers chronic Pseudomonas aeruginosa infections in respiratory disease
… and is associated with the presence of bile acids in the lungs of CF patients, a consequence of micro-aspiration of refluxed gastric contents. This thesis aimed to investigate the impact that bile exerts on the global lung microbiota and the key CF associated pathogen P. aeruginosa. The …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
… should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 signaling pathways, and SHP …
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Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects
… 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology. The 75SeHCAT test, which correlates inversely with faecal excretion and hepatic synthesis of bile acids, is used to diagnose BAM. The aims of the thesis were to study different …
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