Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"bacterial evolution"”.
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An experimental investigation into the mechanisms of bacterial evolution
… thesis studies the two fundamental mechanisms of bacterial evolution — horizontal gene transfer and spontaneous mutation, in the bacterium <em>Escherichia coli</em> through novel experimental assays and mathematical simulations. First, I will develop a growth assay utilizing the quantitative …
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High-throughput experimental and computational studies of bacterial evolution
… in this thesis is concerned with the study of bacterial adaptation on short and long timescales. In the first section, consisting of three chapters, I describe a recently developed high-throughput technology for probing gene function, transposon-insertion sequencing, and its application to the …
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Exploring the Non-vertical Component of Bacterial Evolution Using Network Structures
… genomes. There are an increasing number of evolutionary processes and entities that confuse and confound the traditional understanding of evolution. As a result, these processes and entities are very often omitted from phylogenetic studies altogether. In this thesis I attempt to uncover the …
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Regulation of horizontal gene transfer by intercellular peptide signaling in Bacillus subtilis
… gene transfer plays an important role in bacterial evolution. Although acquisition of foreign DNA can be beneficial to cells, it can also be detrimental. Therefore, cells that possess mechanisms to regulate horizontal gene transfer likely have a competitive advantage. Similarly, several …
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Site Directed Mutagensis of Bacteriophage HK639 and Identification of Its Integration Site
Bacteriophages affect bacterial evolution, pathogenesis and global nutrient cycling. They are also the most numerous and diverse group of biological entities on the planet [1, 2, 3, 4, 5, 6]. Members of the Lambda phage family share a similar genetic organization and control early gene expression …
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The Loss of Methanol Utilization in Methylobacteria
… and R2A with bacteria from MR2A3 then getting a bacterial colony count and also toothpick transfers of the colonies to verify findings. After 20 generations there were no significant decrease in the number of colonies grown on R2A plates and MOM plates. In addition all the colonies grew on the …
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Genetic interaction landscape of the Escherichia coli transcriptional factor machinery
… and cold shock adaptation, respectively. Pan-bacterial conservation suggests that TF genes with similar GI profiles are co-conserved in bacterial evolution. Moreover, the E. coli TF GI network provided deep insights on conserved genetic association across bacterial phyla that can be valuable …
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Hypermutation and adaptation of experimentally evolved marine Vibrio bacteria
… for industrial applications. Experimental evolution is a powerful approach, with microbes especially, but it has mostly been applied to model organisms and metabolic functions. In the work here, we investigated the possibility, degree, and variability of adaptation of an environmental …
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INHIBITOR RESISTANCE MECHANISMS AND INHIBITOR DESIGN IN ¿¿-LACTAMASES
… ever-present problem and is a natural result of evolution; however, it is anticipated that we may exhaust our antibacterial options if new antibiotics are not developed at the speed required by bacterial evolution. ¿¿-Lactams are commonly prescribed antibiotics and ¿¿-lactamases are major …
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Specificity and benefits of an exclusion mechanism for a mobile genetic element in Bacillus subtilis
… Elements (ICEs), plays an essential role in bacterial evolution by helping to promote the spread of genes involved in antibiotic and heavy metal resistance, metabolism, symbiosis, and pathogenicity. Like conjugative plasmids, ICEs spread to new hosts by conjugative transfer through Type 4 …
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Bacterial transport and horizontal gene transfer in subsurface: multiple-scale experimental studies
Horizontal gene transfer rapidly changes bacterial genetic repertoire and contributes to bacterial evolution. Natural transformation, one mechanism of horizontal gene transfer, is defined as the process by which bacterial cells successfully take up and incorporate extracellular DNA. The …
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Evolution and assembly of the ribosome
… protein synthesis in all living cells. A typical bacterial ribosome consists of three ribosomal RNA (rRNA) molecules and approximately fifty ribosomal proteins (r-proteins), which are arranged into two subunits of unequal size and distinct function. The large subunit promotes formation of the …
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Mitybos įtakos aerobinėmis sąlygomis kultivuojamų Mus musculus žarnyno bakteriofagų įvairovei tyrimas /
… present and play a pivotal role in regulating bacterial populations and driving bacterial evolution. The complexity of interactions among bacteriophages, bacteria, and the host organism makes studying the intestinal microbiota particularly challenging due to the multitude of influencing …
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Studying plasmid relatedness and evolution through structural variation
Bacterial cells contain the chromosome (or chromosomes), plus several small DNA molecules which occur at a broad copy number range (from none to potentially hundreds), and replicate independently, called plasmids. They are genetically extremely diverse, and in many cases are able to spread …
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
… resistance, providing us key insight into bacterial evolution and shows that these insights can be applied to directly advance patient care.</p>
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A mechanistic understanding of the postantibiotic effect and treatment strategies
… is due, in part, to the rapid pace of natural bacterial evolution, but also to the overuse and misuse of antibiotics in general. This often selects for drug-resistant pathogens, and allows them to flourish in the face of antibiotic treatment. In addition to the emergence of genetic resistance, …
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The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42
Many gram negative bacterial pathogens utilize a type three secretion system (TTSS) in order to infect eukaryotic cells. A TTSS looks and acts like a molecular syringe, allowing bacteria to inject effector proteins directly into the host cell cytoplasm. These effectors commandeer and manipulate …
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Acquisition and Exclusion of Pathogenicity Island 1 (PAPI-1) in Pseudomonas Aeruginosa
… and is known to play an important role in bacterial evolution and adaptation. Conjugative transfer of genomic islands (GIs) has recently been reported in the opportunistic pathogen Pseudomonas aeruginosa. PAPI-1, one of the largest pathogenicity islands of P. aeruginosa, encodes several …
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Exploring the Population Structure, Recombination Landscape, and Pan-Genome of the Global Neisseria meningitidis Population
… from carriage to invasive disease, and how its evolution impacts efforts to control the disease. The latter has been of particular concern in regions where there have been outbreaks, particularly the ‘meningitis belt’ that spans from West Africa to East Africa, where there is greater disease …
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Coexistence of paralogous quorum sensing systems leads to diverse network topology for coordinating competence and bacteriocin biosynthesis in cariogenic streptococci
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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