Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"autoimmune response"”.
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Defining a Role for Inducible Heat Shock Protein 70 (HSP70i) In Mediating Autoimmune Vitiligo
<p>Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current treatments offer limited efficacy. Observations that heat shock proteins (HSPs) can serve as adjuvants in antitumor vaccines first suggested to …
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Autoantibodies From Patients With Nonallergic Asthma Cause Cytotoxic Injury To Airway Epithelial Cells.
… been reported. And a possible involvement of autoimmune response against bronchial epithelial cell antigen in the pathogenesis of nonallergic asthma has been suggested. To evaluate a functional significance of autoimmune response to airway epithelial cells in the pathogenesis of nonallergic …
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Improving Potency and Oral Bioavailability of Spinster Homolog 2 (Spns2) Inhibitor: A Structure-Activity Relationship Study
In healthy individuals, the autoimmune system is the body's natural defense against foreign materials and organisms. The main tools utilized for this defense mechanism are immune cells. However, in patients suffering from autoimmune diseases, the autoimmune system is overactive resulting in its …
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Circulating Autoantibodies In Human Traumatic Spinal Cord Injury Subjects and Their Relationship to The Development of Neuropathic Pain
… pain (NP) ensues in 40-70% of SCI. An autoimmune response resulting from disruption of the blood-spinal cord-barrier may be a contributor to NP. However, the relationship between autoantibodies and NP after SCI in humans has not been thoroughly characterized nor have autoantigens been …
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Expanding Allergen-specific Tr-1 CD4+ T cells to treat Allergic Asthma
… CD4+ Tr1-like cells that suppresses the autoimmune response via secretion of anti-inflammatory cytokines such as IL-10 and TGF-β. We tested this therapeutic avenue in a chronic model of asthma in BALB/c mice, and found that the pMHC-NP therapy triggers allergen-specific Tr-1 cell …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… of MS patients this cross-reactive antibody response is significantly enhanced and are selectively sequestered in the central nervous system (CNS) suggesting that this cross-reactive immune response may play an active role in the pathogenesis of MS. Immunological cross-reactivity between MOG …
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Clinical Analysis and Review of Literature Associated with Hashimoto's Thyroiditis
… its discoverer Hakaru Hashimoto, is a chronic autoimmune inflammatory disease. HT develops when an autoimmune response causes inflammation of the thyroid gland that ultimately leads to the destruction of thyroid tissue, effectively killing the organ. An affected patient may simply be …
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Elucidating the Role of the α7 Nicotinic Receptor in the Etiology of Schizophrenia.
… of the receptor functioning as antigen in an autoimmune response. Blood sera of schizophrenic patients, as well as controls, were analyzed for the presence of antibodies to the α7 subunit of the nicotinic receptor. A sensitive ligand-based assay revealed schizophrenic patients could possess a …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… (T1DM) is a lack of insulin production caused by autoimmune destruction of the beta-cells, while Type 2 DM (T2DM) is insulin resistance in peripheral tissue that leads to beta-cell exhaustion. Chronic hyperglycemia leads to serious long term complications. Transplantation of whole pancreas or …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Here, we investigated the synthesis of curli in the gastrointestinal tract during Salmonella infection and how host-derived metabolites, like nitrate, are important regulators of biofilm expression in vivo. S. …
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The Hu Syndrome: At the Intersection of Cancer and Autoimmunity
… by tumor cells in the periphery results in an autoimmune response that then targets both the tumor and the nervous system. These diseases offer a unique opportunity to gain insight into the mechanisms behind both tumor immunity and neuronal autoimmunity. The Hu syndrome is an example of PND …
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Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
Autoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. The much more prevalent …
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The TREX1 3' Exonuclease and Autoimmune Disease: Structural and Biochemical Analysis of Disease Mutants Involved in Autoimmune Dysfunction
… Trex1 gene are the underlying cause of multiple autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), and retinal vasculopathy and cerebral leukodystrophy (RVCL). Several cellular roles have been proposed for TREX1 …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… specific T cells are central to the destructive autoimmune response observed in type 1 diabetes (T1D). Not surprisingly, intense focus is placed on understanding how autoreactive T cell responses arise and contribute to disease pathology in the hope of using this information to develop novel …
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
… protein, thereby initiating an anti-tumor immune response that subsequently develops into a neuronal degeneration. Three cerebellar degeneration related (cdr) genes encoding putative antigens were previously identified using PCD antisera. We have demonstrated that cdr2, which encodes a cytoplasmic …
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Formation and Pathogenicity of Cytotoxic Curli Intermediates
… a link between biofilm-associated infections and autoimmune responses in the host. In these studies, we planned to isolate curli from different stages in biofilm development to observe their differences both structurally and through their interactions. We identified turbulence has a significant …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… Primary biliary cirrhosis (PBC) is a chronic autoimmune liver disease in which inflammatory infiltration of the intrahepatic bile ducts leads to damage of the biliary epithelial cells followed by fibrosis, cirrhosis and ultimately liver failure. The disease is characterised by the presence of …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… that in turn amplifies the local inflammatory response (Figure 3.1.14 A). It should however be noted that lethal clinical relapses may also occur in the absence of a pathogenic antibody response if an inflammatory lesion develops in a region of the CNS that is particularly sensitive to damage, …