Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"amyloid aggregation"”.
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Modelling Early Events In Amyloid Aggregation
… of particular significance is the formation of amyloid plaques from normally soluble proteins in several neurodegenerative conditions including Alzheimer’s disease. Traditionally, attention has focused on the proliferation of macroscopic quantities of biofilaments, and experimentalists have …
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EXPLORING THE EFFECTS OF PHYSIOLOGICAL ENVIRONMENT ON AMYLOID AGGREGATION
Molecular level self-assembly/aggregation processes are common in biomolecular systems. Specifically, aggregation of protein molecules results in formation of amyloid deposits, that has been associated with neuronal dysfunction leading up to neurodegeneration. The protein aggregation is often …
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Polysaccharides in Amyloid Aggregation and Hydrogel Mechanics: Insights from Molecular Modeling
… for engineering applications and disease-related amyloid aggregation. A common theme among them is the inherent dynamics and polymorphism of self-assembled structures, which pose challenges to complete characterizations with experimental techniques. We addressed the knowledge gaps in the …
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THE LYSOSOMAL AMYLOID AGGREGATION OF B2-MICROGLOBULIN PROMOTES MULTIPLE MYELOMA PROGRESSION: A MOLECULAR FOCUS ON THIS PRO-CANCER MECHANISM
… studied example is β2-microglobulin (β2m), whose aggregation into amyloid fibrils underlies dialysis-related amyloidosis. Beyond this role, β2m also serves as prognostic factor for several hematological malignancies, including multiple myeloma (MM). Recent studies demonstrated that β2m actively …
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The Role of Metal Ions and Reactive Oxygen Species in beta-Amyloid Aggregation and Toxicity and Their Relevance to Alzheimer's Disease.
The aggregation and deposition of beta-amyloid (AB) in the brain has long been implicated in the neurotoxic pathways causing Alzheimer's disease (AD). Recent data suggests that early, soluble oligomers of Ap are the toxic species. Oxidative stress may be partly responsible for the toxicity of the …
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Effect of de novo peptide properties on self-assembling large amyloid fibers
Amyloid aggregation involves the spontaneous formation of fibers from misfolded proteins. This process requires low energy input, results in robust fibers, and is thus of interest from a materials manufacturing perspective. The effect of glutamine content and hydrophobicity of template peptides on …
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Baltymų amiloidinės agregacijos slopinimui skirtų 5-pakeistų-7H-imidazo[2,1-b][1,3]tiazinų sintezė /
… for Inhibition of Amyloid Aggregation” Supervisor doc. dr. Ieva Žutautė. Vilnius University Faculty of Medicine Institute of Biomedical Sciences Pharmacy and Pharmacology Center. Vilnius, 2024. Aim of study – to synthesize …
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Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
… mit und ohne den HMGB1-Inhibitor Box A auf die Amyloid-Aggregatbildung und den Zelltod erforscht.Die quantitative Auswertung der seriellen immunhistochemischen Färbungen zeigte, dass das β-Amyloid Vorläuferprotein APP und das Zellstress-Molekül αB-Crystallin früh in normal erscheinenden Fasern …
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Macromolecular design for modulation of amyloid fibrillar assembly
Amyloid protein aggregation is notorious for its association with many devastating human diseases such as AIDS, cancer, Alzheimer's disease, and prion diseases. Scientists have made significant progress in designing modulators which prevent amyloid formation and provide potential therapeutics for …
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New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation
… of the enzyme β-secretase and inhibition of the aggregation of beta-amyloid). Therefore, the MTDL strategy seems a more appropriate approach for addressing the complexity of AD and may provide new drugs for tackling its multifactorial nature. In this thesis, it is described the design of new …
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The Identification and Development of Small Molecule Inhibitors of Amyloid β Aggregation
Amyloid $\beta$ (1-42) (A$\beta$42) is a seminal neuropathic agent in Alzheimer’s disease (AD), a multifaceted neurodegenerative disorder for which no preventative measures or disease modifying therapies currently exist. Aggregation of this peptide plays a key role in the synaptic dysfunction and …
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… native conformational state into $\beta$-sheeted amyloid fibrils. In AD the implicated proteins are amyloid-$\beta$ and tau, and for PD the implicated protein is $\alpha$-synuclein (aSyn). The motivation for this work is to develop and use physical techniques to better understand the role of …
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The Pathophysiological Mechanisms of Alzheimer's Disease; Investigating Therapeutic Interventions for Disease Onset
… has focused on the hallmark pathology of amyloid plaques, targeting them to try and prevent disease onset. However, countless failures in clinical trials aimed at this said pathology has led researchers to broaden the horizon of what targets might be successful in mitigating disease. …
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Microfluidics and chemical kinetics to analyse protein interactions, aggregation, and physicochemical properties
… to living organisms; for example, their abnormal aggregation causes neurodegenerative disorders including Alzheimer disease (AD). One of the causes of AD is the presence of amyloid beta peptides Aβ(1-42), Aβ(1-40), which self-assemble into insoluble fibrils and plaques, which surround neuronal …
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Each one teaches one: characterizing active forms of proteins by single molecule force spectroscopy
… in intrinsically unstructured proteins and amyloid formation (Chapter 4). My experimental work investigated both these examples by using in both cases the single molecule force spectroscopy technique (described in Chapter 5 and Chapter 6). The work conducted on angiostatin focused on the …
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Smart Nanomaterials from Repeat Proteins and Amyloid Fibrils
… components for protein-based materials are amyloid fibrils and tandem repeat proteins. Amyloid fibrils are exceptionally strong, tough, highly-ordered structures that self-assemble from a wide range of simple building blocks. Meanwhile, tandem repeat proteins are a class of proteins that act …
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Effects of system complexity on protein aggregation in neurodegeneration
… accumulation of two types of protein aggregates: amyloid β (Aβ) plaques and tau neurofibrillary tangles. The deposition of Aβ can be causally linked to familial and early onset AD, however Aβ-targeting treatments against the more common sporadic form of the disease have so far shown limited to no …
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Investigations on the structure-toxicity relationship of different alpha-synuclein aggregates associated with Parkinson's disease
… alpha-synuclein fibrils and other unrelated amyloid aggregates were able to induce the formation of formazan crystals that resulted in a false-positive result. The nature of this phenomena, the time scale in which it happens, and which species were able to induce it were explored. It was …
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Fluorescence lifetime imaging microscopy to study protein aggregation in the context of neurodegenerative diseases
… are associated with protein misfolding and amyloid aggregation. The work presented in this thesis involves the use of fluorescence lifetime imaging microscopy (FLIM) and other biophysical techniques to elucidate the molecular mechanisms that underlie different amyloid-associated …
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