Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"alpha-SMA"”.
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Determining alpha-smooth muscle actin expression in embryonic and mesenchymal stem cells of assorted mammals seeded in collagen scaffolds in vitro
… by regeneration but the mechanism is unknown. Alpha-smooth muscle actin ([alpha]-SMA) is the protein responsible for contraction, thus determining if it is present in embryos which heal by regeneration will further our knowledge about the causes of regenerative healing. This thesis …
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The recruitment of stromal cells to the site of tumor formation
Myofibroblasts are an alpha-smooth muscle actin ([alpha]-SMA)-expressing cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting angiogenesis and invasion, and we therefore sought to better understand how …
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In vitro pharmacological inhibition of myofibroblast differentiation and force generation in a collagen-GAG matrix
… and expression of the contractile filament [alpha]-smooth muscle actin ([alpha]-SMA), a hallmark of the myofibroblast phenotype. NR6WT fibroblasts were seeded into free-floating cylindrical CG matrices (8 mm in diameter, n=6) and treated with serum-containing media supplemented with …
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Inhibition of myofibroblast contraction
… is inferior to the uninjured nerve: it has a smaller diameter and poorer electrical conduction. Layers of contractile cells known as myofibroblasts have been observed around regenerated nerve portions. An inverse relationship between the layer thickness and the quality of the regenerate has …
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… &beta 1 integrin, and the contractile protein, &alpha-smooth muscle actin (&alpha-SMA) . We report that mechanical loading induces RBL-2H3 degranulation via RGD integrins and regulates age-dependent differences in collagen I and III gene expression in neonatal and adult fibroblasts. We also …
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Morphological characterization of liver fibrogenesis in animal models with genetically modulated TGF-beta signal transduction
… differentiate into myofibroblasts expressing alpha-smooth muscle actin (alpha SMA) which are deposited in the liver to form the extracellular matrix (ECM). At the same time, the process of breaking down or degrading collagen is impaired. In a healthy liver, synthesis (fibrogenesis) and …
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Therapeutic application of dominant-negative PDGF beta-receptor in liver fibrosis
… thus leading to reduced collagen type I(Alphal) gene expression. Adenovirus-mediated sPDGFRBeta gene transfer in HSC in vitro proved highly effective. Infected HSC produced the soluble receptor to scavenge available PDGF-BB and inhibit HSC proliferation. Ad5-CMV-sPDGFRBeta infected HSC …
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The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis
… growth factor beta (TGF-β), and the presence of alpha smooth muscle actin (α-SMA)-positive cells were determined. A compensatory period in mice treated with ethanol occurred early followed by a transition to a dilated phenotype over time. A number of factors may be involved in this process …
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Vergleich der Differenzierungspotentiale humaner mesenchymaler Stammzellen aus dem Knochenmark und aus der Nabelschnur auf kollagenen Matrices
… which could be supported by their alpha-SMA-positivity and typical morphology in electron microscopy, the synthesis of extracellular matrix and their characteristic functional behaviour in terms of a collagen contraction. There were no significant changes concerning differentiation …
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Corneal fibrosis therapies and investigations in the canine corna in vitro
… in expression of profibrotic markers, including [alpha]-smooth muscle actin ([alpha]-SMA; p<0.0001), Fibronectin (FN; p = 0.0002), Tenascin C (TNC; p<0.0001), Collagen I (Col-I; p<0.0001), Collagen IIIA1 (Co-IIIA1; p<0.0001), and Collagen IV (Co-lV; p<0.0001). Conclusion: An ophthalmic formulation …
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Entwicklung eines humanen Cornea-Modells für die okulotoxische Sicherheitsprüfung
… in fibrotische Phänotypen, Fibroblasten und α-SMA-exprimierende Myofibroblasten. Dies war auf den TGFβ-Gehalt des Fötalen Kälberserums (FKS) zurückzuführen, welcher bekanntlich die Myofibroblasten-Differenzierung primärer Zellen in vitro und in vivo stimuliert. Die Einbettung der HCK in das …