Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"alloreactivity"”.
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Investigating the role of HLA class I derived peptide in alloreactivity.
The peptide complexed with human leukocyte antigen (HLA) can be said to have a significant role in the generation of alloresponses, both in terms of cellular and humoral alloresponses. Previous researchers have identified minor histocompatibility antigen (mHAG) derived peptides such as HA-1, and …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… peptide. The integral role of the peptide in alloreactivity was further confirmed by the ability to convert previously non-alloreactive T cell hybrids into becoming responsive with the addition of peptide pools. In addition, the binding affinity and kinetics of LLO118 to its allostimulatory …
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Selective allodepletion to improve anti-viral and anti-leukaemic responses after haploidentical transplantation
… after CD25 depletion. We compared residual alloreactivity to host or 3rd party after CD25 vs combined CD25/71 immunomagnetic depletion in 8 HLA-mismatched donor-recipient pairs. In 1o MLRs, residual responses to host were undetectable after CD25/71 depletion. In 2o MLRs, CD25/71 depletion …
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… editing to mitigate the risks of bi-directional alloreactivity.</p>
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Tumor-induced macrophage and T cell dysfunction
… and increased TBH MΦ suppression during T-cell alloreactivity. TBH suppressor activities were associated predominantly with MHC class II MΦ. TBH class II⁻ MΦ quantitatively and qualitatively suppressed T-cell autoreactivity partly by dysregulation of interferon-gamma (IFN-y), interleukin-4 …
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Structural and electrostatic analysis of HLA B cell epitopes: Inferences on immunogenicity and prediction of humoral alloresponses
… ways to limit the detrimental effect of immune alloreactivity towards the graft is through minimisation of donor-recipient HLA mismatches, but this has not changed conceptually since the early period of clinical transplantation. The central hypothesis of the research described in this thesis is …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… of HLA mismatching and the predicted NK cell alloreactivity did not correlate with the longevity of donor CD4 T cell chimerism, and did not influence the development of BOS. Furthermore, transcriptomic analysis of the donor CD4 T cell population consisted of a heterogenous mixture of different …
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Über den Beitrag von Valpha- und Jalpha-Segmenten des T-Zellrezeptors von CD8 T-Zellen der Ratte bei RT1f-spezifischer Alloreaktion und positiver Selektion im Thymus
Va8.2+ CD8 T-Zellen von LEW.1F Ratten (MHC-Haplotyp f) werden während der Reifung im Thymus zehnfach überselektioniert: 14 Prozent der reifen LEW.1F CD8 T-Zellen exprimieren Va8.2; CD8 T-Zellen von MHC kongenen RT1f- Stämme sind nur zu 1-2 Prozent Va8.2+. Gleichzeitig führt die RT1f-spezifische …
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Evaluation von KIR-Liganden Inkompatibilität bei unverwandten Knochenmark-/ Stammzelltransplantationen
We performed a retrospective study in 185 patients with myelogenous leukemias who had received hematopoietic cells from unrelated donors. The aim of this study was to answer the question wether the benefit of KIR ligand incompatibility seen in haploidentical tranplantations can also be seen using …