Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"adoptive transfer"”.
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Adoptive transfer of immunity to rabies virus
<p>Antigen stimulated lymphocyte cell culture transfer factor, purified by gel filtration and lymphocyte lysate transfer factor, purified by dialysis, was used in efforts to transfer immunity to rabies virus adoptively in various laboratory and wildlife animals. Transfer factor activity was …
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Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
… to induce tolerance in naïve recipients through adoptive transfer of donor primed or unprimed peripheral regulatory cells and/or kidneys from long-term tolerant donor-matched swine. SLAdd miniature swine received 150 rads of whole body irradiation and class I-mismatched SLAgg kidneys from naive …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… autoimmune T cell responses, we utilized an adoptive transfer model of EAE. We found that γSI treatment in vivo reduced EAE severity after adoptive transfer of myelin-specific TCR-transgenic T cells. This was accompanied with a decrease in the production of IFNγ by T cells ex-vivo. To …
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Pathogenesis of the carcinogenic bacterium, Helicobacter pylori
… in H. pylori gastritis. Using a murine adoptive transfer model, adoptive transfer of wildtype (wt) effector T cells (TE) into H. pylori-infected lymphopenic Rag2-/- recipient mice resulted in H. pylori-associated corpus gastritis superimposed with non-specific gastroduodenitis. …
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CNS-Specific, Autoreactive CD8+ T Cells Have a Regulatory Role in Autoimmune Demyelination
… inoculation with a specific neuroantigen or by adoptive transfer of CNS-specific activated T cells. The vast majority of studies in MS and EAE have focused on the role of CD4+ T cells in this disease, with the underlying assumption that MS, like EAE, is a CD4+ Th1-mediated autoimmune disease. …
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T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
… mouse lung and spleen (BALB/c), was examined by adoptive transfer into cockroach (a common inner-city allergen)-sensitized and challenged mice. The adoptive transfer of either of the two subtypes of Tregs reversed AHR and airway inflammation. The cells from the spleen had longer-lasting effect …
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단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할
… with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice compared to BDN mice B. CD4+CD25+T cells were amplified in …
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TFR Cells Suppress Gut Commensal-Specific IgA Via IL-10
… performing 16S sequencing. Additionally, we used adoptive transfer experiments and direct IgA binding assays to probe mechanisms by which TFR cells suppress commensalspecific IgA. We found that Bcl6FC mice exhibited a sustained increase in IgA-coated bacteria following food allergy induction, …
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
… B-ALLs decreased trabecular bone density after adoptive transfer to normal mice, demonstrating a role for RANKL in leukemia-associated bone pathology. Importantly, a RANKL biologic antagonist inhibited CNS dissemination of TM B-ALLs in adoptive transfer experiments. Thus, my studies identified …
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Immunotherapy for murine glioma
… (the anti-immunosuppressant) were combined with adoptive transfer of tumor-specific T cells. Two oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Ra-IL15 and a fluorescent protein (YFP or tdTomato Red). Viral gene expression (YFP …
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The role of gut microbiota in systemic lupus erythematosus
… vancomycin treatment at young age. Importantly, adoptive transfer of Breg cells at 6-7 weeks of age rescued the beneficial effect, which indicates that Breg cells, inducible by vancomycin-sensitive gut microbiota, plays an important role in suppressing lupus disease initiation and progression. …
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The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion
… functions. Our studies also demonstrate that the adoptive transfer of peripherally-induced regulatory CD8+ T cells into recipient mice may allow for the acceleration of pulmonary metastatic disease, suggesting that CD8+ T regulatory cells are capable of antagonizing antitumor immune responses in …
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Quantifying T cell Mediated Killing for Melanoma Immunotherapy
Adoptive cell therapy (ACT), based on the adoptive transfer of tumor-infiltrating lymphocytes (TILs) has well-recognized advantages such as (1) high specificity for target cells; (2) the ability to target even micrometastases; (3) the potential to proliferate in vivo within the host thus increasing …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
… decrease in GC magnitude in aged mice. However, adoptive transfer of SWHEL B cells from 24-month old mice refuted this hypothesis. To understand which cellular factor(s) may be causing the poor GC response in aged mice I used in silico modelling of the GC. This revealed that a combination of a …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
… of bacteria, and bactericidal activity. Adoptive transfer of PMNcyto into Pseudomonas aeruginosa (PA) infected mice showed a markedly reduced inflammatory lung injury. Unlike PMN, the host defense function of PMNcyto waned over time, first observed by in vivo imaging loss in velocity. …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… exclusive CNS or PNS OVA expression. The adoptive transfer of OVA specific MHCI restricted (OT-I) and MHCII restricted (OT-II) TCR Tg T cells extended the OVA Tg mouse model by allowing potentially encephalitogenic T cells to be tracked in vivo. Specificity for the target Ag should enable …
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Preeclampsia, Autoimmunity and The At1 Receptor
… AT1-AA in the pathophysiology of PE, a model of adoptive transfer was generated wherein AT1-AA isolated from human sera are injected into pregnant mice. This autoantibody incites the key features of the disease in pregnant mice: increased blood pressure, proteinuria, renal and placental …
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Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
… enter both normal and inflamed joints after the adoptive transfer to syngeneic recipients. Furthermore, these activated CD4⁺ T cells can transfer disease to naive recipient rats. The arthritogenic population is contained within a subset of CD4⁺ T cells that expresses CD25, MHC class II, CD134and …
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Understanding the Effects of Ageing on B cells Response to Vaccination
… vitro* compared to those from younger donors. Adoptive transfer of B cells from aged SW<sub>HEL</sub> mice into young adult recipient mice showed that differentiation into extrafollicular plasma cells was favoured at the expense of B cells entering the germinal centre (GC) during the early …
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
… in mediating the effects of GA. Moreover, adoptive transfer of CD8+ T cells from GA-immunized (but not OVA-immunized) mice results in amelioration of EAE in CD8(-/-) and wildtype mice, suggesting therapeutic potential for GA-specific CD8+ T cells. These cells appear to mediate their effects …
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