Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"adipocytes"”.
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Adipocytes and Innate Immunity In Systemic Sclerosis
… homeobox homolog 1 (SIX1) in skin-associated adipocytes in SSc skin and the early loss of dermal white adipose tissue (DWAT). We validated the mammalian expression of Six1 in murine dermal adipocytes, and using two transgenic models lacking Six1, we demonstrate that Six1 plays a vital role in …
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Adrenergic control of proteolysis in brown adipocytes
… under adrenergic influence. Mouse pre-adipocytes in culture differentiated to brown adipocytes. Increased expression of UCP1 was induced by norepinephrine (NE). NE was then removed and the pattern of change in thermogenic capacity evaluated. The number of cells and their protein content …
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Exploring the Multifaceted Life of Beige Adipocytes
… While excess accumulation of lipid-storing white adipocytes is usually associated with metabolic complications, brown and beige adipocytes, specialized cell types that disspate energy through heat production, are associated with beneficial outcomes, including increased energy expenditure, improved …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… degrading enzyme phosphodiesterase (PDE) 3B in adipocytes is important for insulin mediated inhibition of lipolysis. The aim of this thesis was to contribute with knowledge on the acute activation of PDE3B in response to insulin and catecholamines in adipocytes. The activation of PDE3B was …
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Characterisation of BMP Processing and Signalling in Adipocytes
… BMP8B processing, regulation and signalling in adipocytes. My findings indicate that BMP8B secretion by mammalian cells is limited, partly due to interactions with cell-surface and matrix-bound extracellular matrix proteins like proteoglycans. This interaction likely involves the prodomain, as …
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Systemic Impact of Insulin-Sensitized Adipocytes and Their Precursors
… has shown that insulin sensitization of mature adipocytes, or of only thermogenic adipocytes, is sufficient to improve global metabolic health. We now report that by sensitizing murine adipocyte precursor cells to insulin action, we can induce durable improvements in glucose tolerance, lower …
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1,25-Dihydroxyvitamin D Regulation of Triacylglycerol Accumulation in Differentiated Adipocytes
… and metabolism in terminally differentiated adipocytes is not yet known. The purpose of this work was to determine the impact of 1,25-dihydroxyvitamin D (1,25(OH)2D), the bioactive vitamin D metabolite, on triacylglycerol accumulation and lipid and glucose metabolism in differentiated …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
… to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin. The adipose tissue conditioned medium (ACM) inhibited the ET-1-induced hypertrophy in a …
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Unraveling the Interaction Between Beige Adipocytes and the Sympathetic Nervous System
… of obesity and its sequelae. While white adipocytes store excess energy, thermogenic brown and beige adipocytes convert lipids and glucose into heat, thereby increasing energy expenditure. Unlike classical brown adipocytes which are thermogenic under basal conditions, inducible brown …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… the regulation of LKB1 signaling pathways in adipocytes, with a focus on SIK2, which is of particulate interest in adipocytes due to its high abundance in these cells. We show that AMPK activity is regulated by LKB1 and CaMKK in adipocytes and describe a regulation of SIK2 and SIK3 by cAMP/PKA …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
… of WAT into brown-like or beige adipocytes, which exhibit the same functional properties as BAT. Browning of WAT is an attractive approach against obesity and insulin resistance. In addition, evidence indicate that activation of the energy sensor AMP-activated protein kinase …
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Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
… adipocyte model, the potential for medullary adipocytes to regulate osteoclast development was tested. Factors important in osteoclast development including RANKL, M-CSF and OPG were expressed by in vitro medullary adipocytes. Furthermore, the expression of these important osteoclast mediators …
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
… insulin-stimulated glucose transport in 3T3-L1 adipocytes, which is in contrast to the effect of AICAR in skeletal muscle. Currently the role of AMPK in adipocytes remains poorly characterised despite the importance of fat tissue in energy homeostasis. To address this, the molecular mechanism of …
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Binding of Insulin to Rat Epididymal Adipocytes and Purification of Their Plasma Membranes
Made available in DSpace on 2014-12-11T22:22:21Z (GMT). No. of bitstreams: 1 7317457.pdf: 7245817 bytes, checksum: 00fbfc363d00915673e1929baba1ebe1 (MD5) Previous issue date: 1972
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The Functional Cellular Identity and Interconversion of Human White, Beige, and Brown Adipocytes
… in the form of increased energy expenditure in adipocytes form the core of this therapeutic potential, little is known about the metabolic differences between white and brown adipocytes, as well as the thermogenic beige adipocytes arising within white adipose tissue upon stimulation, and this …
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
… risk and progression, and high accumulation of adipocytes is increasingly recognized as an active facilitator in the interaction between the tumor and the adipose tissue in the breast. Adipocytes may act as a therapeutic obstacle and can be viewed as a target in breast cancer, as they affect …
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The Role of Adipocytes in the Tumor Microenvironment in Obesity-Driven Breast Cancer Progression
… which predominately consists of mature white adipocytes. In obesity, WAT undergoes hypertrophy and hyperplasia and can ultimately develop hypoxia, insulin resistance, inflammation, and dysregulated endocrine function. Since obesity directly affects WAT, we hypothesized that molecular changes …
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The role of EHD proteins in caveolae, and the role of caveolae in adipocytes
… experience high levels of stress forces such as adipocytes, endothelial cells and muscle cells. Caveolae are generated by the oligomerisation and association of caveolin and cavin proteins, which form the caveolar coat complex at the caveolar bulb and are progressively well characterised. …
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