Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"YAP"”.
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… nuclear activity of yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a range of epithelial-derived cancers, including oral and breast cancers, but their downstream …
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Biophysical profiling of YAP/TAZ dependent mechanical responses
… its downstream transcriptional co-activators, YAP and TAZ, play prominent roles in proliferation, regeneration, and wound healing. Interestingly, these are often found to be dysregulated in aged tissue. Yet, the precise mechanisms of YAP/TAZ regulation on cellular responses in an ageing niche …
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YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… correlated with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in
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YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
… MAPK signaling and the transcriptional activator YAP. Recent zebrafish work established the importance of YAP and de-emphasized the role of MAPK in UM. Here we show that deletion of yap has no significant effect on the incidence, or kinetics, of GNAQQ209L-driven zebrafish UM. Additional …
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
… with higher synthesis in venous regions. YAP and TAZ are paralogous coactivators largely known for their role in the Hippo pathway. They function predominantly through interactions with TEAD transcription factors to regulate transcription of target genes, which ultimately execute the …
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… septum, during embryogenesis. <em>Yap </em>and <em>Taz </em>are downstream effectors of the fundamental Hippo signaling pathway and are vital for proper organ and tissue development, yet their role in neural crest (NC)-derived heart formation is still largely unknown. We generated …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
… inhibitor of Lats kinases, the compound causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound promotes the initial stages of the proliferative regeneration of hair cells, a process thought …
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Vinexin regulates autophagy through YAP/TAZ: implications for health and disease
… I focus on the transcriptional coactivators YAP and TAZ. The rationale here is: 1. YAP/TAZ activity is implicated in autophagy, 2. YAP/TAZ and vinexin are both linked to HCC. My data show that YAP/TAZ transcriptional activity is upregulated upon vinexin depletion. Moreover, increased …
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East Meets West: Desperately Seeking David Dean O'Keefe from Savannah to Yap
… Savannah, Georgia, and the indigenous peoples of Yap. There was no complete written account of his life and his affect on the Yapese culture. Through examination of written documents about O'Keefe, interviews, and personal correspondence, this study yielded a missing piece of history. Although …
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Characterization of the two major merlin isoforms and merlin regulation of YAP
… including upstream regulation of the oncogene YAP through stabilization of the Hippo-pathway kinase Lats, allowing Lats to phosphorylate and inhibit YAP. In this thesis I identify an additional mechanism for merlin regulation of YAP, which occurs independently of the Hippo-pathway-based …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… in stiff matrices through activation of FAK and YAP. Mechanistic studies revealed that integrin signaling induces - via activation SFKs - tyrosine phosphorylation and inactivation of LATS1 and MOB1. The ensuing activation of YAP is necessary for invasive growth of HER2+ breast cancer cells. …
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Functional Regulation of Yap By Aurora A Kinase In Triple-Negative Breast Cancer
<p>The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a …
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Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… main Hippo pathway transcriptional coactivators YAP and TAZ are master regulators of up to 70% of the entire glioma stem cell gene signature and so represent key molecular targets in the development of new therapeutic strategies for GBM. However, targeting these transcription cofactors in the …
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Abundance and Localization of (Yes-associated protein) YAP in Prepubertal Bovine Mammary Tissue
… pathway is mediated by yes-associated protein (YAP) and through downstream gene transcription activation, results in cell proliferation. Because YAP has never been identified in bovine mammary tissue, questions examined in this body of work mainly focused on the abundance and localization of YAP …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in bone are controversial, with evidence for each either promoting or inhibiting osteogenesis in vitro. Here, we used in vivo mouse models of combinatorial YAP/TAZ deletion from …
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Functional Restoration of Irradiated Salivary Glands Through Modulation of aPKCζ and Nuclear Yap in Salivary Progenitors
… aPKCζ and increased nuclear localization of YAP. This part of the study provides novel insights into the regulation of function of salivary gland progenitors, which can be utilized for the development of therapeutic agents to treat salivary hypofunction. Finally, the last chapter describes …
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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… pathway effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates Yap/Taz is not understood. Here I showed that Nf2 regulated the Yap/Taz activity by decreasing the stability of Yap/Taz. The regulation was independent of Yap-S366 phosphorylation, which is …
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Papel de YAP/TAZ en la respuesta de células tumorales a estímulos activadores de receptores de TRAIL
… su rigidez. Los reguladores transcripcionales YAP y TAZ son los principales responsables de la detección de su grado de rigidez. En una matriz extracelular laxa, ambos factores permanecen inactivos en el citoplasma; sin embargo, cuando la matriz se vuelve más rígida, YAP/TAZ se translocan al …
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A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
Uveal melanoma (UM) is a cancer of eye melanocytes that has a particularly poor prognosis and a dearth of treatment options. In contrast to cutaneous melanoma (CM), which is driven by oncogenic mutation of BRAF or NRAS, UM is driven by oncogenic mutations in GNAQ or GNA11 (>80% of patients). We …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
… the transcriptional YES associated protein (YAP), promoting its nuclear exclusion and degradation. Excess YAP activity is oncogenic and is commonly observed in various human malignancies. Despite increased understanding of phenotypes associated with Hippo aberration and excess YAP activity, …
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