Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"XIAP"”.
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The candidate tumour suppressor, XIAP associated factor 1 (XAF1), directly inhibits XIAP activity and induces G1 phase cell cycle arrest
… isolated as novel 34 kDa protein which bound XIAP in a two-hybrid screening. The XAF1A protein consists of 301 a.a. and contains seven potential zinc finger domains. Two alternatively splice variants of XAF1 were later isolated. One isoform (XAF1B) was formed by the removal of a 57 bp exon, …
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Regulation of Apoptosis by XIAP Ubiquitin- Ligase Activity
… obscure. Here, we investigated the function of XIAP ubiquitin-ligase activity by deleting the RING motif via gene targeting in the mouse. Mice expressing XIAP ΔRING were fertile, born in expected proportions, and were not obviously prone to disease in a pathogen-free environment. Removing the …
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DEGRADATION OF XIAP AS A NOVEL TREATMENT STRATEGY IN HIGH-RISK NEUROBLASTOMA
The potential of XIAP antagonism as a treatment strategy for neuroblastoma has not been investigated despite neuroblastoma being an embryonal cancer with a developmental biology requiring XIAP. Here, we showed that the targeting of XIAP, and not other IAP members such as c-IAPs, was necessary to …
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Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the expression patterns of XIAP in various neoplastic thyroid disorders and determine the …
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Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
… that x-linked inhibitor of apoptosis protein (XIAP) expression inversely correlated with sensitivity of cells to therapeutic agents with various mechanisms of action, including TNF-related apoptosis inducing ligand (TRAIL), doxorubicin, cisplatin, paclitaxel, and two ErbB-targeting agents: …
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The Characterization of a Novel Complex Implicated in the Initiation of Apoptosis
… canonical apoptosis proteins. We observed that XIAP, the main caspase inhibitor in mammals, is recruited to a 5Mda complex as early as 30 minutes after stimulation of apoptosis. Furthermore, the recruitment of XIAP to the complex is dependent on the pro-apoptotic protein ARTS, as XIAP is not …
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A Comparison of Cultured Human Dermal Fibroblasts Derived from Terminal and Vellus Hair Bearing Skin. Differences in the expression of inhibitors of apoptosis proteins, oestrogen receptors, and responses to oestradiol under normal and wound induced conditions
… protein expression of Apollon, cIAP2, NAIP and XIAP and their antagonists DIABLO and Xaf1 analysed by qRT-PCR and immunocytochemistry in unwounded and mechanically wounded fibroblast cultures. Differences in proliferation, migration, viability and caspase 3 activity in the presence of …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… role of E. chaffeensis Notch stabilization of XIAP and inhibition of caspase activation. Based on the evidence collected during my research, I have concluded that a TRP120- TR Notch SLiM memetic motif directly binds Notch-1 at a region containing the LBD to activate Notch signaling. TRP120 …
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Characterisation of a protease-dependent gene regulation system for gene therapy applications
… gene X-linked Inhibitor of Apoptosis Protein (XIAP) under the control of this system was examined in comparison to constitutive XIAP expression in the 6-OHDA model. The results showed that regulating XIAP expression with this system afforded greater protection of dopamine neurons in comparison …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… protein X-linked inhibitor of apoptosis protein (XIAP). The C-terminal RING domain of MDM2 binds to the internal ribosome entry site (IRES) of the XIAP mRNA and enhances the IRES-dependent translation of XIAP, which results in increased expression of XIAP and resistance to anticancer treatment. On …
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Nanotherapies for Treating Prostate Cancer
… and X-linked inhibitor of apoptosis protein (XIAP) signaling pathways would be effective in treating prostate cancer. The effect of bicalutamide (antiandrogen) and embelin (XIAP inhibitor) on the growth of prostate cancer cells in vitro and in vivo was first examined. Embelin induced caspase 3 …
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Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
… We identified the target of Smac mimetic to be XIAP, cIAP1, and cIAP2 in both Smac mimetic induced and TNF/Smac mimetic induced apoptosis. Moreover, we were able to mimic the Smac mimetic effect by triple knockdown experiments of IAPs in TNF induced cell death. Furthermore, we identified the …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… hnRNP A1 then binds two anti-apoptotic mRNAs, XIAP and Bcl-X L , believably at Internal Ribosome Entry Sites (IRES) in the mRNAs 5‘ Untranslated Regions (UTR). The hnRNP A1-bound mRNAs are then shuttled to the cytoplasm where they are translated in a 5‘ cap-independent manner following …
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Der Einfluss von HtrA2/Omi auf AIFM1 und MIF in der Zelltodmodalität Parthanatos
… MIF. Der anfangs vermutete Einfluss des Proteins XIAP wurde durch den Inhibitor XB2d89 in Zytotoxizitätsassays untersucht. Der in der durchflusszytometrischen Untersuchung ermittelte Verlust der Membranintegrität zeigte allerdings keinen statistisch signifikanten Anstieg oder Abfall der …
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The identification of NRAGE
… tissue. NRAGE also interacted with the human XIAP in direct two-hybrid tests. The interactions observed in yeast cells were confirmed in mammalian cell culture, employing both coimmunoprecipitation and mammalian two-hybrid methods. Moreover, the results of the coimmunoprecipitation experiments …
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A PROTEIN IN SEARCH OF FUNCTION: NIPSNAP1 IN MITOCHONDRIAL BRANCHED-CHAIN AMINO ACID METABOLON, BRAIN AND APOPTOSIS
… focusing on X-linked inhibitor of apoptosis (XIAP), the most potent member of the IAP family. We cloned, overexpressed and purified the recombinant NIPSNAP1 (~30 kDa) and developed antibodies against the recombinant protein. Sedimentation velocity shows that NIPSNAP1 is a homotetramer. It is …
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Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways
… involved in the pathway, including E3s like XIAP which are also critical components of the apoptotic cascade, as well as potential endogenous inhibitors like ALAD. The data presented in this dissertation suggest a novel interaction between the 20S proteasomal core and ALAD, which results in …
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NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
… cells and cells overexpressing full-length XIAP or the BIR1/BIR2 domains of XIAP were refractory mitochondrial apoptotic events. These data suggest that caspase-mediated positive amplification of initial mitochondrial changes can determine the threshold for irreversible activation of the …
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Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury.
… adenoviral constructs containing either xiap, naip, or lacZ one week prior to QA injections (120 nmol). (Abstract shortened by UMI.)
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
… and mRNA of the IAP Survivin, cIAP1, cIAP2 and XIAP are released into the extracellular space by not only the pancreatic cancer cell line PANC-1, but also from other cancer and non-cancer cell lines. IAP release may play an important role in pancreatic cancer’s lack of response to antimetabolite …
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