Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Wingless"”.
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Regulation of Wingless secretion, distribution and signaling
<p>The evolutionarily conserved Wnt (Wingless and INT-1) family proteins are secreted cysteine-rich glycoproteins essential for embryonic patterning and adult homeostasis. Wnt signaling is highly regulated in all aspects, including the biogenesis and processing of active Wnt ligands, Wnt secretion …
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
The secreted proto-oncogene Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the …
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The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
… is the mediator of the A/P organizer, while Wingless (DWnt-l, a secreted molecule of the Wnt family) is a key mediator of the D/V organizer. In this thesis, several aspects of Wingless function in the wing imaginal disc are examined. Two regulatory mutations, spadeflag (spdfg) and …
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Odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos
<p>Here I report a molecular and genetic analysis of the pair-rule gene odd-paired (opa). Genetically, opa is essential for the appropriate level and timing of en and wg expression in all parasegments, but opa activity alone does not determine the restricted spatial domains of these genes. I …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
The secreted proto-oncogene Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the …
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Functional Analysis Of A Highly Conserved Cyclin, Cyclin Y, In Drosophila Melanogaster
… Cyclin Y is required for phosphorylation of the wingless/Wnt co-receptor, arrow/LRP6, and for full activation of the canonical wingless/Wnt pathway. CycY null Drosophila, however, do not phenocopy loss-of-function mutations in canonical wingless pathway genes, suggesting that Cyclin Y may have …
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Factors influencing populations of the fig pollinator (Liporrhopalum tentacularis) and its parasitoid (Sycoscapter sp.)
… an oviposition bout. The responses of winged and wingless foundresses to varying foundress numbers were different, because the wingless foundresses laid smaller clutches that were independent of foundress number because competition for oviposition sites was reduced. Consequently, wingless …
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Appendage development and early Distal-less regulation in arthropods: A study of the chelicerate Tetranychus urticae (Acarida)
… the candidate antero-posterior positioning genes wingless and engrailed, although one of the two engrailed paralogs I identified is reportedly expressed in posterior segmental compartments, consistent with possible conservation of Engrailed-Wingless interactions in metameric patterning and …
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The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
… required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show that the gpi-linked heparan sulfate proteoglycan Dally is released from cell membranes and …
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
… suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human macrophages in different inflammatory diseases including atherosclerosis. These observations led us to hypothesize that Wnt5a secretion/expression is related to M1 and M2 subsets in …
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Dact Family Molecules In Wnt Signaling In Mouse Development
The Wnt: Wingless-Integration) molecular signaling pathways are known to be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted …
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Phylogeography of Darlingtonea Kentuckensis and Molecular Systematics of Kentucky Cave Trechines
… of one mitochondrial (COI) and one nuclear (wingless) gene were gathered from 60 to 106 terminal taxa, including representatives of all five genera of cave trechines from Kentucky and Tennessee. Alignments were analyzed using maximum parsimony, Bayesian, and maximum likelihood methods of …
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Lost in Translation: Variations in WNT Signaling and Other Translational Changes in a Drosophila Model of ALS
… the glypican Dally like protein (Dlp)/GPC6, a wingless (Wg/Wnt) signaling regulator is insolubilized both in flies and patient tissues with TDP-43 pathology. While Dlp/GPC6 forms puncta in the Drosophila neuropil and ALS spinal cords, it is reduced at the neuromuscular synapse in flies …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
… gradually decreased during in vitro expansion. Wingless-related MMTV integration site (Wnt) is well known signaling molecules that implicated in mesenchymal differentiation during development, but the role in proliferation of hMSCs is not well known. In this study, we investigated the effect of …
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Patterning the Drosophila Embryonic Central Nervous System: Establishing Neuroblast-Specific Gene Expression and Identity
… a group of segment polarity genes---hedgehog, wingless, engrailed, and gooseberry---act in the neuroectoderm and in neuroblasts to regulate the spatial pattern of huckebein, a gene required for the proper development of identified neurons and glia. Along the dorso-ventral axis, the ventral …
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Structural Basis for Dishevelled-2 Association to the Plasma Membrane
The Wingless (Wnt) signaling pathway is one of the critical developmental pathways for control of cell differentiation, proliferation, and cell growth. The DEP domain, located on the C-terminus of Dishevelled (Dvl), plays a role in cytoplasm-membrane association, which branches the canonical and …
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Identification of echinus and characterization of its role in Drosophila eye development
… were observed between echinus and the genes wingless, enabled and expanded. An immunofluorescence assay in Drosophila S2 cell cultured demonstrated that Echinus localizes to intracellular vesicles that do not appear to be endocytic in nature, and the C-terminal region of Echinus was shown to …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
… and are independent of Perlecan’s role in Wingless signaling. Overexpression of Perlecan in motoneurons cannot rescue synaptic retraction phenotypes. Similarly, removing Perlecan specifically from neurons, glia, muscle, fat body, or hemocytes does not cause synaptic retraction, indicating …
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Genetic Profiling in Soft Tissue Sarcoma
… of developmental genes, from e.g. the Wingless and Hedgehog signaling pathways, was demonstrated. The more pleomorphic STS showed overexpression of genes involved in proliferation, adhesion, motility and protein degradation. Moreover, a prognostic signature partly characterized by …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… UCB HSPC and investigate how activation of the Wingless (Wnt) pathway via GSK-3 inhibition can provide a novel approach to improve transplantation outcomes using expanded cells. In vitro and in vivo models of HSPC function were used to evaluate the impact of expansion and GSK-3 inhibition on …
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