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Showing 1 to 20 of 98 for “"Vimentin"”.
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Isolierung und Charakterisierung von Organisationsfaktoren des Vimentin-Filamentsystems
In dieser Arbeit wurden Organisationsfaktoren des Vimentin-Filamentsystems mit Hilfe eines „Y2H“-Systems isoliert und charakterisiert. Als „Fänger“-Protein sollte die alpha-helikale zentrale Rod-Domäne von Vimentin, die den größten Teil des Moleküls darstellt und die im wesentlichen die …
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Interplay Between Keratin and Vimentin Expression in Oral Cancer
… laboratory found that inhibiting expression of vimentin, a marker of epithelial-to mesenchymal transition, inhibited cell growth and motility in vitro and in vivo. Tumors derived from vimentin knockdown cells showed features of epithelial redifferentiation and increased expression of …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
… was identified and validated as cell surface vimentin (CSV). Vimentin is a structural protein universally found in the cytosol but uniquely translocated to the cell surface in metastatic cancer stem cells (CSCs). Our first approach is to optimize the binding of peptoid JM3A on CSV using …
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Impact of Vimentin Intermediate Filaments on 3D Multicellular Collective Behavior
Vimentin, a type III intermediate filament, is an understudied component of the cytoskeletal system. However, in recent studies we can see its structural and mechanical properties aid in a cell's survival and migration. It forms a hyperelastic network and works synergistically with actin and …
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A flotillin-1 és vimentin fehérjék kölcsönhatásának vizsgálata a PP2A Bα fehérjével endotél sejtekben
A flotillin, vimentin, és PP2A B fehérjék kölcsönhatásának vizsgálata, endotél sejtek használatával. Ezen fehérjék tulajdonságait ismertettem. A fehérjéket termeltettük, majd pull down és Western blot kísérletekkel megvizsgáltuk. A kísérletek eredményét részletesen taglaltam, képekkel mellékelve.
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Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells
… Of these, the intermediate filament protein vimentin is frequently upregulated in metastatic carcinomas. Previously, microarray studies showed that the gene encoding vimentin is highly upregulated in metastatic HN12 cells compared to a related primary tumor cell line. In this study, we …
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Characterisation of human surfactant protein A and recombinant human vimentin in their modulation of HPV16 pseudovirus infection
… protein A (SP-A) and recombinant human vimentin (rhVim). Previous work suggested SP-A mediated immune recognition of HPV since SP-A-coated HPV16- PsVs enhanced viral uptake by RAW264.7 murine macrophages. These initial observations were confirmed using a murine C57BL/6 cervicovaginal …
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Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… U18666A treatment affected</p> <p>F-actin and vimentin, but not microtubules. Rhodamine-phalloidin staining</p> <p>indicated U18666A induced F-actin depolymerization. Actin repolymerized</p> <p>when cultures were shifted to leucine-starvation medium. However, this effect</p> <p>did not mediate …
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Telomerase a prognostic marker an therapeutic target
… of telomerase in regulating the expression of vimentin. Vimentin plays an important role in tumour metastasis and is used as an indicator of glioma metastasis. Inhibition of telomerase via sihTERT results in the down regulation of vimentin expression in glioma cell lines in a grade specific …
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Der monoklonale Antikörper Som5H5 : Charakterisierung seines Antigens in der Embryonalentwicklung des Hühnchens
… <br>demnach um das Intermediärfilament-Protein Vimentin des <br>Hühnchens. <br>In immunhistochemischen Färbereihen wurde mit dem <br>Som5H5-Antikörper das Auftreten von Vimentin in <br>verschiedenen Stadien der Hühnchenentwicklung dargestellt <br>und mit dem Muster eines kommerziell erhältlichen …
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The Intracellular Changes and the Localization of Core particles by Hepatitis B Virus P Protein-Deficient Mutant
… using anti-HBc antibody. Microtubules, vimentin, nuclear pore complex (NPC) were visualized using mouse anti-tubulin, mouse anti-vimentin, and mouse anti-NPC antibody, respectively. RESULTS: P-deficient mutant core particles co-localized with microtubule, NPC, and vimentin, like HBV wild …
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Biochemical and Immunocytochemical Characterization of Canine Corneal Cells Cultured in Two Different Media
… Immunocytochemical staining for pancytokeratin, vimentin, and E-cadherin was evaluated, and immunofluorescence for zonula occludens-1 was attempted. Amplification of cytokeratin 5 (CK5) mRNA was assessed by PCR. Primary presumed epithelial cells grew faster when cultured in DMEM with FBS compared …
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Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
… capsular stem cells were EMA (MUC1)+, MDM2+, Vimentin+ and Wnt1+; progenitors of the sub-capsular nephrogenic zone were MDM2+ and Wnt1+; cap mesenchymal cells were EMA (MUC1)+, CD15+, vimentin+, Wt1+, CD10+, Bcl2+, Wnt1+ and PAX2+; interstitial progenitor cells were Vimentin+, Wt1+ and …
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Identification & characterization of natural and synthetic compounds as new anticancer agents
… target of Z-ajoene is the cytoskeleton protein Vimentin. Z-ajoene interacts with Vimentin through a S–thiolation causing the disruption of Vimentin filaments and therefore an alteration of the cell morphology. Given that Vimentin is known to participate to the early stage of the metastatic …
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Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
… marker of central nervous system development), vimentin (which is ubiquitously expressed in mesenchymal cells), and the glucocorticoid receptor (GR, which is involved in the immune response, cell proliferation, and apoptosis) have been shown to interact in embryonic and undifferentiated tissues …
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O-GlcNAc-Mediated Protein-Protein Interactions in Cell Signaling
… protein-protein interactions, including vimentin, an O-GlcNAcylated intermediate filament (IF) protein. Vimentin is important for the integrity of mesenchymal cells and has been implicated in cell movement and various metastatic cancers. The purpose of vimentin glycosylation remains …
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Validierung von miRNA-Zielgen-Interaktionen und ihre Charakterisierung bei Motoneuronerkrankungen
… zwischen der miR-17-3p und dem Zielgen Vimentin, welches in Wobbler-Tieren verstärkt exprimiert ist, festgestellt werden. Weiterhin konnte gezeigt werden, dass diese miRNA das Protein- und das mRNA-Niveau von Vimentin negativ reguliert. Die verstärkte Expression und Akkumulation von …
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ROR1 and Rab27b – novel biomarkers for chemoresistance in ovarian cancer
… were also stained and scored for ROR1(and vimentin). Kaplan-Meir survival analysis was carried out to investigate the impact of ROR1 (and vimentin) on patient outcomes. HEY cells were found to be the most resistant (p<0.05) and invasive (p<0.001) while OVCAR-3 was the opposite (p<0.001). …
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Cancer cell behaviour following parasite exposure
… and the expression of two markers of metastasis: vimentin and N-cadherin. Importantly, N. brasiliensis antigen significantly lowered the expression of cell-surface vimentin, while decreasing Human Papillomavirus type16 pseudovirion internalization. In vivo infection with N. brasiliensis …
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