Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"VMH"”.
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A Molecular Dissection of the Ventromedial Hypothalamic Nucleus
<p>The ventromedial hypothalamic nucleus (VMH) plays an important role in the regulation of food intake, glucose metabolism, and body weight. However, in contrast to other hypothalamic nuclei that are also known to regulate energy homeostasis, there is a paucity of nucleus-specific marker genes for …
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The effects of chronic electrical stimulation of the ventromedial hypothalamic nucleus in the rat.
… repeated exposure to ventromedial hypothalamic (VMH) stimulation. In the first experiment, body weight, food intake, and epididymal fat pad weight were evaluated in three groups of rats receiving either VMH stimulation, no stimulation (implanted control), or stimulation to areas adjacent to the …
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Role of the ventromedial hypothalamus in control of innate defensive behaviours
… these behaviours. Ventromedial hypothalamus (VMH) is a key brain region for controlling responses to predators; it has been shown that inactivating the VMH can reduce defensive behaviours. Interestingly, activating the VMH output neurons (SF1+ cells) can produce a variety of different …
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Identification of central circuitry components mediating anorexigenic properties of oxytocin
… (MPOA) or the ventromedial hypothalamic nucleus (VMH), mediates OT-driven hypophagia in energy- and reward-related ingestive behaviors. I provide insights into mechanisms underlying OT-driven anorexia mediated by the hypothalamus by (a) defining whether OT MPOA or VMH administration affects …
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Possible role of the ventromedial hypothalamus in estrus termination following vaginocervical stimulation of the rat
… the role of the ventromedial hypothalamus (VMH) in estrus termination using sexually experienced ovariectomized female rats. First, females were administered subcutaneous injections of estradiol benzoate and progesterone before being assigned to 4 different treatment groups. The first group …
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Hypoglycemia-induced changes in glucose metabolism in the hypothalamus
… occurring in the ventromedial hypothalamus (VMH), a brain region that is responsible for initiating the counterregulatory response to hypoglycemia (4) is the most promising target. In the following studies, we utilized metabolomic (Chapter 2), transcriptomic (Chapter 3), and isotope tracer …
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Behavioral and Neurochemical Effects of Neonatal Administration of Monosodium L-Glutamate in the Mouse.
… the ventromedial nucleus of the hypothalamus. (VMH) produce overeating and obesity. Their observation served to focus attention on the central nervous system (CNS) as the site of systems that regulate food intake.
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Altered Fuel Supply and Utilization in the Hypothalamus Following Recurrent Hypoglycemia
… that local substrate concentrations in the VMH are altered by RH and are affected by glycogen availability and noradrenergic activity. The changes in local energy supply contribute to the impaired CRR seen in RH, supporting a role for altered metabolism in HAAF.
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Mechanisms of intake depression in parasitised lambs
… the activity of the ventromedial hypothalamus (VMH) using mederantil, a compound with the active ingredient brotizolam, which blocks the diazapem receptor in the VMH. The second eXI)eriment utilised loxiglumide (CR1505) which antagonises the peripheral receptor of cholecystokinin (CCK). For each …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… in neurons in the ventromedial hypothalamus (VMH); this will decrease ceramide content specifically in this brain region vital to the control of glucose homeostasis and body weight. We found that ceramide accumulation in the VMH during obesity drives glucose intolerance without changing body …
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Neuroanatomical specificity of prolactin-induced hyperphagia and expression of fos-like immunoreactivity following central administration of prolactin
… nucleus (PVN), ventromedial nucleus (VMH), and medial preoptic nucleus (MPOA) in the hyperphagic actions of PRL. Ad libitum fed virgin female rats received twice daily site-specific injections of PRL (800 ng) over a period of 10 days. Only subjects demonstrating regular vaginal …
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Exploring INSL5 and RXFP4 in the gut-brain axis and their potential role in feeding behaviour
… DRG, NG and the ventromedial hypothalamus (VMH), a known feeding centre in the brain. Transcriptomic analysis of Rxfp4-expressing cells in the hypothalamus revealed enriched expression of multiple feeding-related neuropeptides and receptors. Circuit mapping of hypothalamic Rxfp4-expressing …
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CHARACTERIZATION OF TRANSMEMBRANE PROTEIN 35 EXPRESSION: CONSIDERATIONS OF SEX AND OVARIAN HORMONES
… of TMEM35 in both the ventromedial hypothalamus (VMH) and the limbic circuit of the mouse brain. Due to the known functions of these two regions, this pattern of expression indicates possible roles of this neuropeptide in social behavior and reward processing. Interestingly, TMEM35 mRNA expression …
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Mechanisms of hypothalamic regulation of food intake in birds
… nucleus (PVN), ventromedial hypothalamus (VMH), and arcuate nucleus (ARC), were collected 5 days later. Real-time PCR was used to measure the mRNA abundance of appetite-associated neuropeptides and receptors in each nucleus. The results showed that the two lines displayed distinct gene …
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Does the Stria Terminalis Carry Information Concerning Feeding and Body Weight Regulation from the Posterodorsal Amygdala to the Hypothalamus?
… degenerating terminals in the shell of the VMH and the premammillary nuclei, indicating that the dorsal component of the stria terminalis had been severed. The results of ibotenic acid lesions of the posterodorsal amygdala are unable to be reported due to the inability to histologically …
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Mapping the neural circuits that underlie metabolic vs. emotional regulation of food-seeking behavior
… to identify a neural circuit from the VMH via aPVT<sup>CRF</sup> neurons to the NAc shell that suppresses food-seeking behaviors in the presence of predator-related odor. Next, by using in vivo single-unit recordings from projection-defined neurons in the prelimbic cortex (PL), an input …
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Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
… in the ventromedial nucleus of the hypothalamus (VMH) resulting in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy homeostasis, we employed a screen to search for genes that were dysregulated in GTG induced obese mice. In this screen, GPR7, the …
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Metabolic signalling and neuroendocrine stress responses in pregnancy
… area (LPIA), ventromedial hypothalamus (VMH) and dorsomedial hypothalamus (DMH). Supraoptic and magnocellular PVN oxytocin responses to centrally administered NPY were reduced during late pregnancy. Endogenous opioids are involved in the attenuation of HPA axis responses to orexin and NPY …
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A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… hypothalamus (DMH), ventromedial hypothalamus (VMH) and the nucleus accumbens (Acb). Excessive consumption palatable sucrose sucrose was was ameliorated in mutants by intraperitoneal administration of oxytocin (OT), a satiety promoting neuropeptide whose dysregulated release is also associated …