Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"VDAC1"”.
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VDAC1P8 as a Novel Regulatory Element in Leukemogenesis: Integrative Genomic, Epigenetic, and Functional Insights [VDAC1P8 come nuovo elemento regolatorio nella leucemogenesi: approfondimenti genomici, epigenetici e funzionali integrati]
… mammiferi sono presenti tre diverse isoforme: VDAC1, VDAC2 e VDAC3. Pur condividendo un'alta omologia di sequenza, queste isoforme presentano funzioni e caratteristiche distinte. In particolare, VDAC1 è frequentemente sovraespresso nei tumori, ed uno degli aspetti più studiati è la sua …
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The impact of glucotoxicity on pancreatic β-cell function
… are associated with increased level of VDAC1 and reduced level of VDAC2 accompanied with marked reduction of GSIS. Similar to glucose, 2-deoxy-glucose also increased the expression of VDAC1. Addition of glycogen synthase kinase 3β (GSK-3β) inhibitor reversed the alteration in VDAC1/VADC2 …
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Regolazione trascrizionale delle isoforme VDAC umane: analisi dei loro profili di espressione, dell'attività del promotore e dei regolatori trascrizionali
… famiglia multigenica che include tre isoforme (VDAC1-3) codificate da tre diversi geni nucleari. Nonostante esse condividano un’elevata similarità nella sequenza e nella struttura, studi funzionali fatti negli ultimi anni sulle proteine VDAC suggeriscono che ciascuna isoforma svolga ruoli …
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Protein Misfolding and Aggregation in Neurodegeneration: In Vitro And In Vivo Study Cases
… and sporadic ALS. The mitochondrial porin VDAC1 has been proposed as a binding target of SOD1 mutant forms to mitochondria. By affinity studies we found that VDAC1 protein specifically binds SOD1-G93A but not wild type SOD1. Notably, it is known that the N-Terminal end of Hexokinase 1 …
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Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
… 2 (GOT2) and voltage-dependent anion channel 1 (VDAC1) were validated as potential markers of MPTP-induced toxicity using western blot analysis. In parallel, a study of the mitochondrial phosphoproteome was undertaken. Despite the limitations of detection methods, a change in the phosphorylation …
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VDAC and SOD1: two major players in mitochondrial metabolism and in ALS
… is able to forms smaller pores compared to VDAC1, under physiological condition of pH. Another point examined here has been the gating of VDAC1. This protein, in vitro, shows the important feature of gating the pore in dependence of high voltage applied. It is believed that the N-terminal …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… voltage-dependent gating protein 1 (VDAC1). Subsequent VDAC1 activation and autophagic cell death was observed. Downregulation of VDAC1 ameliorated the cytotoxic effect of OSW-1 in melanoma, indicating that VDAC1 was critical to mediating OSW-1’s activity. Studies with OSW-1 resistant …
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Caratterizzazione del ruolo della Superossido Dismutasi 1 (SOD1) in relazione al metabolismo mitocondriale
… parte favorito dalla presenza della proteina VDAC1 (Voltage Dependent Anion Channel). Essa, localizzata sulla membrana mitocondriale esterna, assicura la sua permeabilità, favorendo gli scambi di metaboliti e ioni tra il mitocondrio e il citosol. In S.cerevisiae la delezione del gene che …
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Inter-Organellar Nucleic Acid Communication by a Mitochondrial tRNA Regulates Nuclear Transcription
… of mito-tRNA-Asn and NARS2 was dependent on the VDAC1 mitochondrial channel and importin-α nuclear transport factor, respectively. Mito-tRNA-Asn promoted the interaction of NARS2 with histone deacetylase 2 (HDAC2) and repressed HDAC2 association with chromatin. Accordingly, inhibiting …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
… to the voltage dependent calcium channel 1 (VDAC1) binding to Bax. We were able to provide important data relevant to future experimental researchers such as on the possibility of Bax to cross biological membranes and the most relevant amino acid residues in VDAC1 that interact with Bax. </p>
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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem
… a significant decrease in mRNA levels for VDAC1 isoform, suggesting that Pb decreases VDAC protein expression through decreased transcription. A proteomics approach was then used to confirm that Pb exposure during development results in changes in proteins involved in energy metabolism in …
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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem
… a significant decrease in mRNA levels for VDAC1 isoform, suggesting that Pb decreases VDAC protein expression through decreased transcription. A proteomics approach was then used to confirm that Pb exposure during development results in changes in proteins involved in energy metabolism in …
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Formazione di proteine canale: dal mitocondrio a SARS-CoV-2. Caratterizzazione funzionale e strutturale attraverso l'uso di tecniche respirometriche e di dinamica molecolare
… lavoro di tesi, viene approfondito il ruolo che VDAC1 può avere nella regolazione delle funzioni di respirazione mitocondriale, attraverso specifiche tecniche di respirometria. In maniera analoga verrà analizzato anche il ruolo degli aggregati di α-sinucleina e della tossina MPP+, entrambe …
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Analisi elettrofisiologica delle proteine VDAC umane incorporate nei nanodischi e indagine sui residui di cisteina dell'isoforma 3 VDAC nella funzionalità mitocondriale e nel tamponamento dei ROS
… esistono tre diverse isoforme, conosciute come VDAC1, VDAC2 e VDAC3. Pur condividendo un'alta omologia di sequenza, le tre isoforme presentano funzioni e caratteristiche diverse. La prima parte di questa tesi di dottorato si focalizza sull'analisi elettrofisiologica delle proteine VDAC prodotte …