Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"UTP"”.
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USIMPL: An Extension of Isabelle/UTP with Simpl-like Control Flow
… verification that builds on Foster’s Isabelle/UTP with features of Schirmer’s Simpl in order to achieve a modular, scalable framework for deductive proofs of program correctness utilizing Hoare logic and Hoare-style algebraic laws of programming.
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Il nucleotide extracellulare UTP: induzione della migrazione di cellule staminali emopoietiche CD34+
… la capacità dei nucleotidi extracellulari ATP ed UTP di promuovere, in associazione alla chemochina CXCL12, la migrazione di cellule staminali umane CD34+. E’ così emerso che la stimolazione con UTP è in grado di incrementare significativamente la migrazione dei progenitori emopoietici in risposta …
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How do disclosures of tax uncertainty to tax authorities affect reporting decisions? : evidence from Schedule UTP
… Uncertain Tax Position Statement (Schedule UTP) to examine the effect of mandatory disclosures of tax uncertainty to tax authorities on firms' reporting decisions. Schedule UTP requires firms to disclose federal income tax positions to the Internal Revenue Service that have been classified …
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Einfluß von extrazellulären Nukleotiden auf den eosinophilen Granulozyten
… daß im entzündlichen Gewebe hohe ATP- und UTP-Spiegel vorliegen. Ich habe daher in dieser Arbeit die biologische Aktivität von Nukleotiden in eosinophilen Granulozyten, sowie die Beteiligung der verschiedenen Purinorezeptoren untersucht. Im Rahmen dieser Arbeit konnte erstmals der Nachweis …
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Extracellular Nucleotides Induce Transient Elevation of Cytosolic Calcium in Articular Chondrocytes
… concentration of cytosolic free calcium. ATP and UTP induced large transient elevations of calcium in the majority of cells tested (71 of 83 cells and 82 of 147 cells, respectively). In contrast, UDP produced a modest increase of calcium in 21 of 92 cells. ATP, UTP and UDP demonstrated homologous …
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THE ROLE OF P2Y RECEPTORS IN HUMAN VASCULAR SMOOTH MUSCLE
… augmented by ATP in SV cells only. Surprisingly, UTP and UDP reduced the PDGF mediated response in both IMA and SV cells using pH]-thymidine incorporation, a colorimetric proliferation assay and cell counting as indexes of mitogenesis. 2MeSADP and AR-C67085MX were ineffective, ruling out the …
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Cytoplasmic RNA-dependent RNA-synthesis in maturing chicken erythrocytes.
… primer dependent enzyme activity, incorporating UTP, CTP and to a lesser extent ATP and GTP into homopoly-ribonucleotide material. The ribosome-bound enzyme preparation demonstrated in addition, the synthesis of heteropolyribonucleotide material. A complementary DNA copy of chicken globin mRNA …
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Effector Response of the Aspartate Transcarbamoylase From Wild Type Pseudomonas Putida and a Mutant with 11 Amino Acids Deleted at the N-terminus of PyrB.
… but also the effector binding sites for ATP, UTP and CTP at its N-terminus. In this work, 11 amino acids were deleted from the N-terminus of PyrB and the ATCase with the truncated protein was expressed in E. coli pyrB- and purified. The wild type enzyme was similarly treated. …
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A Study of the Pyrimidine Biosynthesis Pathway and its Regulation in Two Distinct Organisms: Methanococcus jannaschii and Pseudomonas aeruginosa
… enzyme by the nucleotide effectors ATP, CTP and UTP. In this research project we have genetically manipulated the M. jannaschii pyrI gene and have been able to assemble a 310 kDa E. coli like enzyme. By using the second methionine in the sequence we have shown that the enzyme from this organism …
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Mitogene Effekte extrazellulärer Nukleotide in humanen Mesangialzellen
… konnte gezeigt werden, dass extrazelluläres ATP, UTP und verschiedene weitere Nukleotide zu einer deutlichen Steigerung der DNS-Synthese führen. <br>ATP hat die Rolle eines Komitogens, da ATP alleine nicht wohl aber in Kombination mit PDGF den ganzen Zellzyklus aktiviert, inklusive Steigerung der …
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An in vitro system for studying the mechanism of action of thyroid hormones
… hormones had no effect on the incorporation of UTP-³H into nuclear RNA which is evidence that the primary site of action of the hormones is in the cytoplasm, i.e., the conversion of IMP to AMP and to GMP. The net effect is to maintain a high adenine nucleotide/guanine nucleotide ratio. The …
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High Frequency Ethernet Cabling Analysis and Optimization
… and predicting NEXT in unshielded twisted pair (UTP) using Category 6 cables as an example. The results obtained from the evaluation were used to provide crosstalk parameters for fast NEXT prediction in Category 6 (UTP) cables. The research used the measured NEXT of three Category 6 (UTP) cables …
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The role of the P2Y2 nucleotide receptor in salivary gland regeneration
… receptor equipotently activated by ATP and UTP, is upregulated in a variety of tissues, including salivary gland epithelium, in response to injury or stress and is proposed to play important roles in the regeneration of a variety of tissues. The results presented in this dissertation …
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Charakterisierung von purinergen Rezeptoren an kultivierten Podozyten der Maus
Extrazelluläre Nukleotide wie ATP und UTP sind wichtige Regulatoren glomerulärer Funktionen. In der vorliegenden Arbeit wurde die Reaktion von kultivierten Mauspodozyten auf purinenerge Agonisten mit der Saug-Elektroden Technik und intrazellulärer Ca2+-Messung (Fura 2) beobachtet, die eine …
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Characterization of the regulatory domain of the mammalian multifunctional De Novo pyrimidne biosynthetic enzyme CAD
… pathway. It undergoes feedback inhibition by UTP and activation by PRPP, a purine precursor that coordinates purine and pyrimidine biosynthesis, and by cAMP-dependent protein kinase phosphorylation. Several lines of evidence have demonstrated that the carboxyl end (B3) of the CPSase molecule …
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Effect of aflatoxin on mitochondrial transcription and translation
… In the assay system used the incorporation of ³H-UTP into acid-insoluble product was inhibited 52% by actinomycin D (50µg/ml) and the labeled product was sensitive to pancreatic RNase. Aflatoxin B₁ inhibited in vitro mitochondrial ³H-UTP incorporation only 12% at high concentrations (0.4 mM or 130 …
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Characterization of Moraxella bovis Aspartate Transcarbamoylase
… ATCase holoenzyme is inhibited by CTP > ATP > UTP. The Km for aspartate is 1.8 mM and the Vmax 1.04 µmol per min, where the Km for carbamoylphosphate is 1.05 mM and the Vmax 1.74 µmol per min.
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A verified compiler for Handel-C
… context of the Unifying Theories of Programming (UTP). Our UTP denotational semantics not only provided a model for our theory (hence, proving its consistency) but also allowed us to prove all the axioms in the compilation framework.
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… β2 adrenergic receptors and Gq-coupled UTP-binding P2Y purinergic receptors on H9c2 cells. Activation of the adenosine A1 receptor with CPA (N(6)-cyclopentyladenosine) provided significant protection against hypoxia-induced cell death in these cells, as did opening of a BKCa channel with …
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Clinical and Biological Aspects of Cardiovascular microRNA
… inflammation in response to extracellular ATP/UTP. In Study I and II, we found that cardiac-enriched miRNAs are increased 100-3000 fold within 12 h following onset of symptoms in patients with myocardial infarction and that the levels of two specific miRNAs, miR-208b and-499-5p, could be used …
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