Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Tyk2"”.
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Role of Tyk2 in the Development of Beige Cells
… previously discovered that Tyrosine Kinase 2 (Tyk2), an important mediator of cytokine signaling, promotes the development of classical brown adipose tissue. Due to the lack of functional BAT, Tyk2-knockout (Tyk2-/-) mice become grossly obese with age and develop several symptoms of the …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… cancer. First, we investigated the role of Tyk2 tyrosine kinase in the pathogenesis of breast cancer. Here we show for the first time that compared with wild type mice, Tyk2 -/- mice show increased tumor growth rate as well as metastatic disease and splenomegaly when inoculated with 4T1 …
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Analysis of Human Interferon Signaling and its Regulation
… active Janus kinases JAK1 and tyrosine kinase 2 (TYK2) phosphorylate signal transducer and activator of transcription 1 (STAT1) and STAT2, which act as a transcription factor together with IFN-regulatory factor 9 (IRF9) to induce antiviral IFN-stimulated genes (ISGs). Unraveling the complex and …
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Modulation der IL-6-abhängigen Signaltransduktion durch die Protein-Tyrosinphosphatase SHP2
… deficient in Jak1, Jak2 or tyrosine kinase 2 (Tyk2) were stimulated with IL-6/soluble IL-6R complexes it was found that only in Jak1-, but not in Jak2- or Tyk2-deficient cells, SHP2 activation was greatly impaired. It is concluded that Jak1 is required for the tyrosine phosphorylation of SHP2, …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
… Second, PAO inhibits the activation of JAK1 and TYK2, probably due to the oxidation of vicinal thiol groups. Thereby, the activation of the STATs is inhibited. Although in many studies PAO is used as a phosphatase inhibitor, comparative studies with pervanadate do not support this function in our …
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Charakterisierung der Interaktion von gp130 und Jak1
… was used to show that Jak1, Jak2 and Tyk2 have an influence on the surface expression of gp130. Not its kinase activity, but the 3-dimensional structure of Jak1 seems to be responsible for this effect. The upregulation seems to be dependend on internalization, because after mutation of …
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Die Regulation der Expression des humanen Oncostatin-M-Rezeptors durch Januskinasen
… case of the OSMR, activation of Jak1, Jak2 and Tyk2 have been reported. Apart from their function in OSM signal transduction, a novel role of Jaks could be established in the present study: Upon heterologous expression of the OSMR in several cell lines, its surface expression was significantly …
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Relevanz der Transmembran- und Intrazellulärregion von gp130, LIFR und OSMR für deren Liganden-induzierte Signaltransduktion
… LIFR recruits the Janus kinases Jak1, Jak2 and Tyk2; the membrane distal tyrosine residues are sufficient for activation of the transcription factors STAT1 and STAT3. The OSMR in contrast recruits via its cytoplasmatic tyrosine residue 861 specifically the adapter protein Shc. Point mutation of …
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Untersuchungen zur gp130/Jak1-Interaktion
… kinases of the Janus family (Jak1, Jak2 and Tyk2). Since Jak1 plays the most important role the interaction of gp130 with Jak1 was investigated by means of mutagenesis of both molecules. The minimal binding region of Jak1 to gp130 was restricted to the membrane proximal 68 amino acids. W666 …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… a common missense mutation P1104A in a protein TYK2 was discovered as the first genetic predisposing factor to TB in humans. TYK2 P1104A selectively impairs IL-23-dependent IFN-γ production by lymphocytes.In light of these findings, I hypothesized that a partial impairment of IFN-γ immunity due …
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Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10
… Nachfolgend werden die Januskinasen Jak1 und Tyk2 und die Transkriptionsfaktoren Stat3 und Stat1 durch Phosphorylierung aktiviert. Die Folgen dieser Kaskade sind die Transkription verschiedener Gene, deren Endprodukte die Wirkung von IL-10 vermitteln. Da die Transkriptionsfaktoren Stat3 und …
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Das Tyrosin 759 des Signaltransduktors gp130 in der IL-6-abhängigen Proliferation von Prä-B-Zellen
… th gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3. SHP2 …
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Early life phenotypes of type 1 diabetes genetic risk
… D metabolism CYP2R1 gene and the gene encoding TYK2 known for its susceptibility to infections. Examination of longitudinal phenotypes identified that infancy growth is influenced by genes with a key role in innate immunity, e.g. IFIH1. The strongest associations were found between skinfold …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
… associated with the Janus kinases Jak1, Jak2 and Tyk2. Additionally, the intracellular part of gp130 displays six tyrosine motifs. The four membrane distal tyrosine motifs are able to recruit the STAT factors STAT1 and STAT3. Once recruited, STAT factors are phosphorylated, dimerise and …
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Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling
… data suggests the potential role of JNK and TYK2 in mediating these interactions, respectively, and thus my work has provided preliminary, albeit testable, hypotheses for elucidating the possible mechanisms responsible for this rewiring of the ERK pathway. My work has also identified the …