Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Tyk2"”.
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Role of Tyk2 in the Development of Beige Cells
… previously discovered that Tyrosine Kinase 2 (Tyk2), an important mediator of cytokine signaling, promotes the development of classical brown adipose tissue. Due to the lack of functional BAT, Tyk2-knockout (Tyk2-/-) mice become grossly obese with age and develop several symptoms of the …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… cancer. First, we investigated the role of Tyk2 tyrosine kinase in the pathogenesis of breast cancer. Here we show for the first time that compared with wild type mice, Tyk2 -/- mice show increased tumor growth rate as well as metastatic disease and splenomegaly when inoculated with 4T1 …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… a common missense mutation P1104A in a protein TYK2 was discovered as the first genetic predisposing factor to TB in humans. TYK2 P1104A selectively impairs IL-23-dependent IFN-γ production by lymphocytes.In light of these findings, I hypothesized that a partial impairment of IFN-γ immunity due …
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Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10
… Nachfolgend werden die Januskinasen Jak1 und Tyk2 und die Transkriptionsfaktoren Stat3 und Stat1 durch Phosphorylierung aktiviert. Die Folgen dieser Kaskade sind die Transkription verschiedener Gene, deren Endprodukte die Wirkung von IL-10 vermitteln. Da die Transkriptionsfaktoren Stat3 und …
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Early life phenotypes of type 1 diabetes genetic risk
… D metabolism CYP2R1 gene and the gene encoding TYK2 known for its susceptibility to infections. Examination of longitudinal phenotypes identified that infancy growth is influenced by genes with a key role in innate immunity, e.g. IFIH1. The strongest associations were found between skinfold …
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Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling
… data suggests the potential role of JNK and TYK2 in mediating these interactions, respectively, and thus my work has provided preliminary, albeit testable, hypotheses for elucidating the possible mechanisms responsible for this rewiring of the ERK pathway. My work has also identified the …