Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 4344 for “"Tumor"”.
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
… manifestations can vary from indolent localized tumor to widespread metastases. This heterogeneity is also observed at the molecular level both inter- and intra-patient. Intra-patient heterogeneity in the clinical setting of men with castration resistant prostate cancer (CRPC) might be …
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Tetracycline in Tumor
The attraction of the tetracycline antibiotic for any rapidly growing tissue has been repeatedly observed. This phenomenon is shown by a yellow golden fluorescence of the tissue when placed under an ultraviolet light. The cause of this phenomenon is not known, but is thought to be an …
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Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity
… immunity cannot only function as an extrinsic tumor suppressor, but also shape tumor immunogenicity. These observations led to the development of the cancer immunoediting hypothesis that stresses the dual host-protective and tumor-sculpting actions of immunity on developing cancers. We …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… and colon cancer; moreover, it functions as a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In this study, we show that a putative tumor suppressor, miR-145, is regulated through the phosphoinositide-3 kinase (PI-3K)/Akt and p53 pathways. Importantly, p53 …
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Targeting Tumor Metabolism, Optimizing the tumor microenvironment for radio- and immunotherapy combinations
Contains fulltext : 310749.pdf (Publisher’s version ) (Open Access)
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Modeling and computer simulation of tumor growth and tumor response to radiotherapy
… it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed …
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Noninvasive Assessment of Tumor Hypoxia Using MRI in Clinical and Preclinical Tumor Models
Tumor oxygenation influences response to radiation and plays important roles in malignant progression, angiogenesis and metastasis. While methods are available to quantitatively map pO2 dynamics in preclinical studies, new techniques are needed to noninvasively characterize tumor hypoxia and …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
… considered as a late event in the primary tumor process. Recent evidence suggests that tumor cells dissemination may occur when the tumor is at a size that does not normally warrant a systemic treatment. Current breast cancer models developed as part of the Cancer Intervention and …
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Priming systemic anti-tumor immunity via in situ immunomodulation of the tumor microenvironment
… in a subset of cancer patients by driving tumor-directed immune responses. However, many patients do not benefit from such immunotherapies due to immune resistance mechanisms or severe inflammatory adverse events resulting in treatment discontinuation. Direct intratumoral injection of …
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The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… cells.</p> <p>However, IL-8 is also produced by tumor-associated stromal cells. In bone marrow derived stromal cells (HS5), I demonstrated a feed forward loop occurs as was observed in tumor cells. HS5 conditioned media increased Src activity in PCa cells. By silencing IL-8 in HS5 cells, Src …
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A three-dimensional in vitro tumor model representative of the in vivo tumor microenvironment
… reproduce the complexities of the in vivo tumor microenvironment with reductionist-based two-dimensional in vitro cell culture models has been a notable deterrent in identifying therapeutic agents that reliably translate to in vivo animal and human clinical trials. In an effort to address …
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Targeting Nanoparticles to Tumor Vasculature
Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use escape mechanisms against chemotherapeutic agents as frequently as tumor cells …
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Tumor suppressor pathway in myocardium
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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NMR imaging of tumor angiogenesis
… the US annually. A common feature of most human tumors is their ability to induce the proliferation of new blood vessels, i.e. angiogenesis. Considerable evidence now exists which demonstrates that these tumor vessels are associated with a distinct range of morphological and physiological …
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Antibody engineering for tumor immunotherapy
… is the retention time of antibody in the tumor relative to normal tissue. In this Thesis, we have attempted to elucidate the mechanisms that are most influential to improving antibodies as cancer therapeutics. Carcinoembryonic antigen (CEA) has long been identified as a tumor-associated …
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Intra-tumor heterogeneity and evolution
… many cancers are extremely hard to treat. Tumors likely resist treatment because each tumor is heterogeneous, and can evolve. Although tumor evolution has long been appreciated, it remains incompletely understood. In this thesis, I will explore two questions related to cancer heterogeneity …
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Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and 18F Misonidazole PET in Murine Tumor Models
http://pubs.rsna.org/doi/full/10.1148/radiol.2015150416
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Enhancing Adoptive Cell Therapy By Augmenting Fitness and Anti-Tumor Function of Tumor-Infiltrating Lymphocytes
… offers an <em>in vivo</em> approach to activate tumor-specific T cells, albeit in some cases, this modality does not create a sufficiently robust anti-tumor response. Thus, <em>ex vivo </em>approaches employing manipulation of immune cells, such as Adoptive Cell Therapy (ACT) using autologous …
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