Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"Transmigration"”.
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Aliens en route : European transmigration through Britain, 1836-1914
… of transport and maritime studies that shows how transmigration has been under appreciated by both maritime and migrants historians alike.
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… endocytic vesicles that coalesce into transmigration pores, through which leukocytes transmigrate without disrupting EC junctions. The contribution of CAM-mediated endocytosis to the formation of docking sites and vesicular structures supporting TEM was explored in this study. Results …
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Transmigration and its centre-regional context : the case of Riau and South Kalimantan Provinces, Indonesia
This thesis analyses transmigration policy in Indonesia within the context of centre and regional relationships. The evidence from Riau and South Kalimantan suggests that as a consequence of the unequal relationship between the centre and the regions, the implementation of transmigration policy has …
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Transmigration and its centre-regional context : the case of Riau and South Kalimantan Provinces, Indonesia
This thesis analyses transmigration policy in Indonesia within the context of centre and regional relationships. The evidence from Riau and South Kalimantan suggests that as a consequence of the unequal relationship between the centre and the regions, the implementation of transmigration policy has …
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Negotiating community amongst spatial and identity boundaries : the case of "unity in diversity" in the transmigration settlement of Mopugad, Indonesia
… the islands of the archipelago. Known as transmigration, the program resettled people from Java and Bali, two islands experiencing overpopulation, urbanization and increasing poverty, to the "Outer Islands" of Sumatra, Kalimantan, Sulawesi, the Moluccas and Papua. One of the objectives of …
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Development and Characterisation of a Vessel-On-a-Chip Model of Inflammation and Inflammatory Haemostasis
… thesis, an organ-on-a-chip model of immune cell transmigration was developed and characterised. The OrganoPlate (Mimetas) was used to develop an inflammation-on-a-chip model consisting of a vessel of human umbilical vein endothelial cells (HUVEC) against a 3D extracellular matrix (ECM). …
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Development of a novel in vitro model to study the tryptic : endothelial cells, monocytes and flow
… of a novel in vitro model of monocytes transmigration under flow and use in the study of early molecular events of atherogenesis. In this work, we focused on how endothelial dysfunction, specifically mediated by disturbed flow from atherosusceptible regions of the vasculature, is both …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… an early event in tumor cell (TC) adhesion and transmigration across vascular barriers. But how glycocalyx of TC affects TC adhesion and transmigration is unclear. Whether or not glycocalyx can be a target for tumor metastasis is also understudied. Therefore, the 2D BBB generated from HCMECs was …
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Akkumulation von T-regulatorischen Zellen im humanen Pankreaskarzinom durch selektive Tumorendothel vermittelte Adhärenz- und Transmigrationssteigerung
… und in vivo zu selektiv verstärkter Adhäsion und Transmigration von Tregs durch Tumorendothel führte. Die Treg selektive Tumorinfiltration wurde in vitro und in vivo unter anderem durch Bindung von CD62L, ß-7 Integrin und CD166 an ihre tumorendothelial exprimierten Bindungspartner MAdCAM-1, …
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The Drivers of Government Megapolicies: Internal Settler Colonisation in Indonesia
… this model manifests in context-specific ways. Transmigration is the world’s largest and longest-running population resettlement programme and a megapolicy par excellence. I analyse archival sources on transmigration from the ISEAS Library and National Library of Australia. The case demonstrates …
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Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade
… the process. In this initial study, neutrophil transmigration was successfully reduced by 66% using protein synthesis inhibitors, a combination of puromycin and anisomycin. Our strategy, if fine-tuned, could form the basis of a new clinical strategy for the prevention of ARDS.
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Engineered microvasculature platforms to study tumor-host-matrix interactions during metastatic seeding
… was a critical prerequisite for successful transmigration, as well as basement membrane breaching. Combined with validation from in vivo metastasis assays, we find that tumor beta-1 integrin is a critical mediator of extravasation and metastases formation. Furthermore, we demonstrate the …
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Einfluss des Leukotrienrezeptorantagonisten Montelukast auf die Chemotaxis eosinophiler Granulozyten durch Endothelzellen
… hiernach die Aktivierung und damit auch die Transmigration über kompetitive Blockade des CysLT1-Rezeptors aufheben. Diese Hypothese setzt die Expression des Leukotrienrezeptors auf Eosinophilen voraus. Mit dem Nachweis der mRNA für den Leukotrienrezeptor konnten wir Hinweise für dessen …
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Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
… α3 promoted the polarization, proliferation, and transmigration of Th17 cells, and integrin α3-deficiency enhanced the retention of CD4+ T cells in the perivascular space of the blood-brain barrier. Notably, differential RNA-seq expression analysis revealed that Th17 cells continuously depend on …
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U0126, MEK1/2 inhibitor, Induces Adhesion Molecules Expression in Human Blood Cells
… adhesion molecule play crucial roles in monocyte transmigration and adherence to endothelial cells, causing inflammatory responses in vascular lesion. MAPKinase pathway has been known to be activated in inflammatory responses. In this study, we investigated the expression of adhesion molecule by …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
… dynamic imaging techniques. We found that MSC transmigration is associated with both leukocyte-like and novel mechanisms, including nonapoptotic migratory blebbing. In the fourth chapter, we address the importance of non-endothelial factors in MSC trafficking to inflamed tissues, including …
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A Microsystems Approach for Drug Assessment
… designed in this work is made of a silicon-based transmigration well with a 30µm-thick membrane and 8µm pores. This platform includes a deep microfluidic channel on the back-side sealed with a glass wafer. Using this platform, the migratory behavior of highly metastatic breast cancer cells, …
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Flow-induced mechanotransduction in cell-cell junctions of endothelial cells
… rapid junction disassembly in the leukocyte transmigration and junction formation in subconfluent cells.
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Funktion von NF-kappa B für die Differenzierung lymphoider Zellen und die inflammatorische Aktivierung von Endothelzellen
… einen Einfluss auf die in vitro Adhäsion und Transmigration von Monozyten.
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Developing In Vitro and In Vivo Models for Lyme Neuroborreliosis (LNB)
… required for the blood-brain barrier (BBB) transmigration of B. burgdorferi. Second, we established a middle-aged mouse model for studying neuroinflammation associated with LNB. Last, we further characterized a Caenorhabditis elegans (C. elegans) model to study B. burgdorferi-associated …
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