Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Translational regulation"”.
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Translational regulation in aggressive B-cell lymphomas
… new possibilities to explore mechanisms of regulation beyond the level of transcription. Ribo-Seq is a technique combining ribosome footprinting with deep sequencing of mRNA fragments that allows to map the position of translating ribosomes with single nucleotide precision. Here I …
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Translational Regulation of the C-Jun Proto-Oncogene
… oncogenes such as <em>ras</em> and <em>src</em>. Regulation of <em>c-jun</em> activity has been studied at the level of transcription, dimerization, DNA binding and post-translational modification. I report here that the <em>c-jun</em> proto-oncogene can also be regulated at the translational …
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Translational Regulation in the 5′UTR of Enteroviruses
… AUG (uAUG), where UP is encoded. Analysis of the translational landscape of infected cells, through profiling of initiating ribosomes, demonstrated that both the uAUG and uuAUG codons can be used as sites of translation initiation. Using luciferase reporters, we determined the efficiency of …
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Translational regulation by short RNAs in mammalian cells
… of animals is thought to depend upon the regulation of gene expression and not the number of genes in a genome. Gene expression is a highly conserved process in which genes encoded by DNA are transcribed in the nucleus into messenger RNA, spliced, and exported to the cytoplasm, where they …
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RNA Localization and Translational Regulation on the Endoplasmic Reticulum
… cellular mechanism for the spatiotemporal regulation of protein expression and serves important roles in oogenesis, embryogenesis, cell fate specification, and synapse formation. Signal sequence-encoding mRNAs are localized to the endoplasmic reticulum (ER) membrane by either of two …
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Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
… (TGF-β) receiving attention for its up-regulation in the metastatic tumor microenvironment. TGF-β facilitates EMT through a variety of mechanisms but a prominent feature of TGF-β induced EMT is the activation of the transcription factor zinc finger E-box-binding homeobox 1 (Zeb1). …
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Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation
<p>The regulation of protein synthesis is an important aspect of the control of gene expression in neurons and is thought to contribute to neurologic diseases such as Fragile X mental retardation syndrome. We demonstrate that several neuronal RNA-binding proteins implicated in human disease are …
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Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
Regulation of the amount and activity of Binding Immunoglobulin Protein (BiP) contributes to protein-folding homeostasis. BiP’s abundance is modulated transcriptionally by the canonical unfolded protein response (UPR). Conversely, a metazoan-specific, endoplasmic reticulum (ER)-resident, Fic domain …
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Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… class of small RNAs, microRNAs (miRNAs), which translationally repress the production of proteins by binding to target sites on messenger RNA (mRNA). MiRNAs provide a sophisticated way to adjust protein levels in a spatiotemporal manner. One miRNA may control several mRNAs, including …
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Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
The epitranscriptome -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --
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Fragile X Mental Retardation Protein Induces Synapse Loss Through Acute Postsynaptic Translational Regulation
… RNA-binding protein that plays a complex role in translational regulation. FMRP may be an important regulator of dendritic protein synthesis, which occurs at or near synapses in response to synaptic activity. Many types of long-term synaptic change require local protein synthesis for their …
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Post-translational Regulation of Plant Fatty Acid Desaturases as Expressed in Saccharomyces cerevisiae
… BF3. These differences are attributed to post-translational modification and have been shown to be controlled by an Nterminal element. I attempted to determine specific amino acids important for regulation, and further characterize the mechanism contributing to the differences. Through …
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Global transcriptional, post-transcriptional, and translational regulation during soybean seed and seedling development
The regulation of gene expression is maintained in a highly organized fashion to ensure specific genes are expressed at the appropriate levels during soybean seed and seedling developmental stages. To define the developmental shifts in gene expression and begin to understand the gene regulatory …
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The role of RNA localization and translational regulation in Drosophila germ cell determination
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Novel insights into the post-translational regulation of an ER localised ubiquitin conjugating enzyme
Ube2J1 is an enzyme that helps cells degrade misfolded proteins at the endoplasmic reticulum. This study shows it is controlled by several signalling pathways, and regulated by previously unidentified mechanisms. Ube2J1 also boosts replication of Vesicular Stomatitis Virus when active. These …
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Post Translational Regulation of AID Targeting to Both Strands of a Transcribed DNA Substrate
… underscores the importance of understanding its regulation throughout the genome. Action of AID on genes outside of the Ig loci can lead to genomic instability. Hyperactivity of AID has been shown to cause chromosomal translocations and other oncogenic malignancies. Loss of AID can lead to …
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
Major depressive disorder (MDD) is a leading cause of disability worldwide, with nearly one-third remaining treatment-resistant. Chronic stress is a major risk factor for MDD, whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid …
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Molecular requirements for FMRP and RNA helicase MOV10 in the translational regulation of co-bound mRNAs
… However, FMRP's role in microRNA-mediated translational regulation has remained unclear. In this work, we studied the interaction of FMRP with RNA helicase MOV10. The purpose is to gain insight into how the formation of the FMRP-MOV10 RiboNucleoProtein (RNP) complex can facilitate or …
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