Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 169 for “"Transcriptomic analysis"”.
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Transcriptomic analysis of pancreatic cells in zebrafish
… the first part of my thesis was to determine the transcriptomic signatures of each pancreatic cell type in zebrafish in order to identify novel cell type-specific regulatory genes that might be crucial for their differentiation and/or physiology. Pancreatic acinar cells, ductal cells as well as …
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Transcriptomic analysis of sugar accumulation in sorghum
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Streamlining and standardizing transcriptomic analysis in Amgen process development
… and synthesizing biological data; such as transcriptomic (gene expression), proteomic (protein levels), or metabolomic (metabolite levels). This thesis describes a streamlined workflow for analyzing transcriptomic data. This streamlined workflow not only reduced the barrier to conducting …
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Transcriptomic Analysis for the Identification and Prioritization of Treatment of Abdominal Aortic Aneurysms
Abdominal aortic aneurysms are pathological dilations of the abdominal aorta, characterized by a high mortality rate, and a lack of effective prognostic predictors. As the disease progresses, the aortic wall becomes significantly degraded and eventually the structure is compromised, leading to …
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Transcriptomic analysis of metabolic processes in near-isogenic and inbred purple corn pericarp
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-08-01
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Resolving Cell Fate: Experimental, computational and mathematical methods in single cell transcriptomic analysis
… unprecedented granularity. A comprehensive analysis of FLK1+ cells harvested from gastrulating murine embryos was performed. In-silico reconstruction of pseudo-temporal and pseudo-spacial relations were demonstrated. Using prior knowledge of known driver genes deeper substructure was …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
… gene expression. Cell-type based gene network analysis further demonstrated that common signalling pathways and biological processes converged on cell types with enriched expression patterns of ASD risk genes. Through comparative analysis, I further identified conserved and distinct expression …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… for the further investigation and comparative analysis of the roles of each HIF-α isoform in-vivo in the syngeneic KaLwRij mouse model.
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… impairments. The study investigated single-cell transcriptomics and DNA methylation changes as potential drivers of persistent cellular dysfunction after radiation exposure, specifically concentrating on the CA1-3 regions of the hippocampus and the prefrontal cortex due to their role in cognitive …
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Spatial transcriptomic analysis of low-grade intestinal T-cell lymphoma and lymphoplasmacytic inflammatory bowel disease in cats
… from cats with LGITL and IBD using spatial transcriptomics, formalin-fixed paraffin-embedded cat jejunum and ileum samples were used, six with a diagnosis of LGITL and six with a diagnosis of IBD. Endoscopy biopsies and full-thickness biopsy and necropsy samples were included. Three ileum …
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Transcriptomic analysis of the response of the lactic acid bacteria Lactococcus piscium for the identification of possible adaptive genes during thermal shock in cold and warm temperatures
Psychrotrophic lactic acid bacteria (LAB) play a versatile role in research, food, farming and medicinal applications, but also play a role as a source of food spoilage. The effects of temperature changes has yet to be studied in depth. In this study, to analyze in a transcriptome level, cold and …
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Two strategies to deepen knowledge the antibiotic resistance related traits in Italian MDR Staphylococci: comparative transcriptomic of two DAP-R/DAP-S MRSA isogenic couples and CRISPR system characterization of pathogenic S. epidermidis
… gene acquisition by S. aureus. A comparative transcriptomic analysis by RNA-seq and bioinformatic of two Methicillin-Resistant S. aureus isogenic pairs, the characterization of the CRISPR-Cas system and phage infection sensitivity tests of ten Italian pathogenic clinical MDR S. epidermidis …
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Decoding the Transcriptional Specificity of Auxin Signaling: A Synthetic Biology Approach
… we developed an open-source, R-based analysis pipeline to process flow cytometry data generated by protoplast transient expression assays. This reproducible workflow automates transformation-based reporter analysis, streamlining quantification of gene expression and effector function …
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IMPACTS OF TROPICAL PEAT-FOREST SMOKE: URBAN PM2.5 AND TOXICITY IMPLICATIONS
… differentiated at air-liquid interface (S-ALI). Transcriptomic analysis identifies 273 dysregulated genes involving >60 signaling pathways. An alveolar-endothelial co-culture model further demonstrates epithelial exposure to PM2.5 reduces angiogenic ability of endothelial cells through bystander …
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Transcriptiome analysis of a migraine model
… included Aldh1a1 and Slc7a2. A comparative transcriptomic analysis offered insights for migraine therapies.
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Elucidating the underlying mechanisms of diabetic endotheliopathy using patient specific induced pluripotent stem cells
… of diabetic vasculopathy. Here we utilize transcriptomic and proteomic technologies to assess patient-specific iPS-ECs from diabetic (DiPS-ECs) and non-diabetic (NiPS-ECS) donors in order to investigate the mechanisms driving endotheliopathy in diabetes. <br/><br/>Our in vitro and in vivo …
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Targeting DNA Repair in Prostate Cancer: Therapeutic Combinations & Disease Models
… cell cycle progression signatures. Cell cycle analysis demonstrated G2/M accumulation, providing indications of delayed cell cycle progression due to DNA damage in the combination treatment. With regards to ATM inhibition, AR-null prostate cancer cell lines were observed to be highly sensitive …
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Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
… microscopic tumor lesions. Through genomic and transcriptomic analyses, we pinpointed the importance of macrophages, particularly those expressing high levels of CSF1R, in these microscopic metastatic focal lesions. We conducted macrophage- targeted immunotherapy using anti-CSF1R. Treatment of …
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GENOMIC AND PHYSIOLOGICAL INSIGHTS INTO BACTERIAL HEAVY METAL RESISTANCE MECHANISMS FOR ENVIRONMENTAL DECONTAMINATION
… wastewaters; (2) Genome sequencing and transcriptomic analysis of Rhodococcus erythropolis strain SC26 provide insights into its Cr(VI) reduction pathways; (3) Characterization of Cd resistance and plant growth-promoting (PGP) bacteria contributes to knowledge of plant-microbial …
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