Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"Toxicity testing"”.
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Novel approaches to toxicity testing in Daphnia magna
… mechanistic information for ecotoxicological testing. In this thesis, metabolomics is explored as a novel method for toxicity testing using Daphnia magna. Initially I evaluated the potential application of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) based …
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Development of methodology for community level toxicity testing using the fathead minnow seven day survival-growth impairment test
Single species toxicity tests are widely used to assess the potential effects of a toxicant on aquatic life. Increasingly, it is necessary to understand how the results of these tests relate to toxicant effects in natural communities. This dissertation presents the methodology and validation for a …
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Sacrifice or Salvation: How can Animal Lives be Spared and Human Health Improved by Toxics Reform?
… between animal cognition, the use of animals in toxicity testing, and the proliferation and impacts of harmful chemicals in our society. It asks how, in light of the most current research on animal sentience and the ethics of responsibility, a reorientation of chemical testing at a theoretical, …
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Development of an embryo-larval chronic toxicity test using the sea urchins Tripneustes gratilla and Echinometra mathaei
Toxicity tests use organisms to assess the effects of the bioavailable fraction of toxicants in effluents and environmental media, such as water and sediment. Test organisms must be highly sensitive and ecologically relevant. Gametes of the sea urchins Echinometra mathaei and Tripneustes gratilla …
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Ecotoxicological Evaluation of Hollow Fill Drainages in Low Order Streams in the Appalachian Mountains of Virginia and West Virginia
… water/sediment chemistry, acute water column toxicity testing using <i>Ceriodaphnia dubia</i>, chronic sediment toxicity testing using <i>Daphnia magna</i>, benthic macroinvertebrate surveys, and <i>in situ</i> Asian clam (<i>Corbicula fluminea</i>) toxicity testing. Common significant …
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Properties of Waste Resulting from Arsenic Removal Processes in Drinking Water Treatment
… was leached to the liquid portion over time. Toxicity testing was performed on the residuals at 20% and 100% after two months and six months of storage. Bench-scale sand drying beds were used to dewater residuals, and the leachates were analyzed to determine if arsenic leached from residuals. …
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Entwicklung eines Hepatozytenbioreaktors zur Anwendung in der Toxikologie und Metabolismusforschung
New approaches for in vitro testing of hepato-mediated toxicity are undertaken to offer alternatives to in vivo animal testing. The described bioassay for hepato-mediated toxicity testing is based on a small scale hepatocyte-bioreactor with pig hepatocytes connected to a silicon sensor based …
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Xenobiotic metabolism and zebrafish (danio rerio) larvae
… due to the application of this organism to toxicity testing and ecotoxicology. Genes similar to mammalian cytochrome P450 (CYP) 1A1, CYP2B6, CYP3A5 and UDP-lucuronosyl-transferase (UGT) 1A1 were demonstrated to be expressed during normal embryonic development, with increased expression post …
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Negative phototaxis of mosquito larvae as a potential tool in the rapid biological monitoring of aquatic wastes (Diptera: Culicidae)
A little-known approach to toxicity testing--based on negative phototaxis of larval <u>Aedes aegypti</u>--was investigated as a contribution to the search for rapid methods applicable to the field of water pollution control. Zinc and copper were the toxicants tested. All tests were conducted with a …
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The Survival and Growth of Fish in a Settled Industrial-Domestic Effluent
Selected aspects of the literature on the toxicity to fish of metal mixtures in the absence and presence of organic matter are reviewed. A continuous-flow tank apparatus for long-term toxicity testing of a humus tank effluent (Minworth Sewage Works, Birmingham) is described. The 50 and 95 …
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Toxicant-releasing substrates: a new method for delivering copper to microbial communities in SITU
… to those generated using standard, laboratory toxicity testing protocols during a summer and winter experiment. Chemical-releasing substrates were successfully used to deliver copper to periphyton communities in a predictable manner, over a broad range of doses, and at fairly constant rates …
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Pretreatment and biodegradation of wastewater from a textile dyeing and finishing industry
… to complete organic removal as well as remove toxicity and metals. The wastewater from the textile dyeing and finishing industry studied was not treated efficiently and often failed effluent toxicity and metals tests. In this research project, various pretreatment alternatives were studied in …
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Chemical, Toxicological, and Microbial Characterization of New Orleans Sediments Following Hurricane Katrina
… after the storm, sediment was collected and toxicity was tested using Japanese medaka (Oryzias latipes) embryos. Sediments with the highest contaminant levels showed the highest embryonic mortality and most delayed development. However, no sediment caused an increased mutant frequency. When …
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Analysis of Zero-Heavy Data Using a Mixture Model Approach
… is motivated from problems of chronic toxicity testing which has a data set that contains a high proportion of zeroes. The analysis of chronic test data is complicated because there are two different sources of zeroes: mortality and non-reproduction in the data. So researchers have to …
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DRUG TOXICITY STUDIES BASED ON VIRE2-GFP MOBILITY INSIDE PLANT CELLS
Testing the toxicity of a drug candidate is an essential process for drug development. Any failure to detect severe toxicity or side effect timely would certainly lead to health concerns and economic loss. From the period between 1953 and 2014, a total of four hundred and sixty-one drugs were …
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Separation of gliadin peptides for investigation of the injurious agent(s) in gluten sensitive enteropathy
… generation of celiac active peptides for future toxicity testing.
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Characterization of a new miniaturized hollow-fiber bioreactor for cultivation of cell lines and primary cells to improve cytostatic drug testing in vitro
… use of the hollow-fiber bioreactor as a tool for toxicity testing was investigated, as current models for toxicity as well as efficacy testing of drugs in vitro allow only limited conclusions with regard to the in vivo situation. Examples of the drawbacks of current test systems are the lack of …
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Combined effects of bioavailable organic contaminants in the aquatic environment.
… overcome many of the challenges associated with toxicity testing of hydrophobic substances, which can bias the interpretation of toxicity data. The present study investigated the feasibility of coupling silicone rubber passive sampling devices (SR-PSDs) with bioassay techniques for both chemical …
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Overcoming the seasonal variations in fitness of the amphipod Corophium Volutator as an environmental toxicology test species using laboratory cultured specimens.
… in the fitness of C. volutator may make toxicity testing impossible during summer months. C. volutator were cultured in the laboratory to determine if variations in the fitness of wild C. volutator could be overcome with the use of cultured specimens. Adult and neonate C. volutator were …
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Leveraging cell micropatterning technology for rapid cell-based assessment of chemical toxicity and population variation in toxicity susceptibility
… presents a unique and costly challenge to toxicity testing in the 21 st century. In recent years, the United States has seen large coordinated efforts across governmental agencies to shift from expensive and slow traditional in vivo tests to more affordable and higher throughput in vitro …
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