Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 209 for “"TRP"”.
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Molecular Determinants of TRP Channel Gating
<p>Transient Receptor Potential (TRP) ion channels are a family of proteins that contribute to a myriad of physiological functions. They have been extensively studied since their discovery 35 years ago; however, there are still many questions regarding the mechanisms by which they function. This …
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Group III mGluR8 negatively modulates TRP channels
… this could occur through modulation of TRP channels on nociceptors. The following studies used a multifaceted approach to examine the interaction between group III mGluRs (mGluR8) and two TRP channels: TRPV1 and TRPA1. In the first study, we examined the interaction between group III …
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Modulation of synaptic transmission by TRP channels
… sensory receptors, Transient Receptor Potential (TRP) channels, are expressed not only at peripheral terminals, but also at the central terminals of sensory neurons. While the role of these channels at the periphery is detecting environmental stimuli, their function at central terminals is not …
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ATP, TRP channels and airway neuronal sensitisation
… roles of ATP and transient receptor potential (TRP) channels in chronic cough by working with primary bronchial epithelial cells (PBECS) and an in-Vitro human sensory neuronal model differentiated from human dental pulp stem cells termed peripheral neuronal equivalents (PNEs). TRP channels are …
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Eisenia hortensis Detects Chemesthetic Irritants through TRP Channels
… a common Transient Receptor Potential 1 (TRPA1) channel agonist, we hypothesized that earthworms possess TRPA1-like channels. We examined whether the earthworm Eisenia hortensis possesses TRPA1-like channels, as well as other TRP channel members. We assessed whether E. hortensis could …
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Gating Mechanisms of The Canonical Trp Channel Isoform Trpc4
… by Transient Receptor Potential Canonical (TRPC) proteins play important roles in regulatory and pathophysiological processes. These channels are known to be activated downstream from phospholipase C (PLC) signaling. However, the mechanism by which the PLC pathway activates TRPC4/C5 remains …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functions. TRPVanilloid 1 and TRPVanilloid 4 are proposed to be involved in inflammation-induced pain. TRPV1 is extensively studied and it is specifically involved in inflammatory thermal hypersensitivity. …
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Chemesthesis in the Earthworm, Lumbricus terrestris: The search for TRP Channels
… to humans. Currently, there are no reports of TRP channels in earthworms. Earthworms, including Lumbricus terrestris, aerate and enrich soil providing a suitable habitat for plants. Hence, chemicals in the soil which repel earthworms could have deleterious effects on plant growth. Allyl …
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Distribution and function of TRP ion channels in primary sensory neurons
… of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The CB1 receptor agonists anandamide and HU210 …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… <p>An abundance of research implicating TRP channels in rheumatoid arthritis synovial fibroblasts pathogenic phenotype has accumulated over the past decade. Studies of the rheumatoid synovium demonstrate the expression of several of these channels including TRPV1, TRPV2, TRPV4, TRPA1, …
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Role of Trp Channels In Mediating The Calcium Signaling Response of Brain Endothelial Cells to Mechanical Stretch
… Antagonist of transient receptor potential (TRP) channel subfamilies, TRPC and TRPP, demonstrated a reduction of the stretch-induced Ca<sup>2+</sup> influx. RNA silencing directed at individual TRP channel subtypes revealed that TRPC1 and TRPP2 largely mediate the stretch-induced …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… that a non-specific cation channel of the TRP family could be involved. In Chapter 4, commencing with a list of 14 TRP channels that share several of the above properties, ICC and flow cytometry experiments are presented that indicate that the DAG-sensitive channels TRPC6 and TRPA1 are …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… that a non-specific cation channel of the TRP family could be involved. In Chapter 4, commencing with a list of 14 TRP channels that share several of the above properties, ICC and flow cytometry experiments are presented that indicate that the DAG-sensitive channels TRPC6 and TRPA1 are …
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Untersuchungen des adjuvanten Effekts des viralen Tegumentproteins VP22 auf die Induktion Melanom-spezifischer cytotoxischer T-Zellen in C57BL/6 Mäusen nach DNA-Immunisierung
… durch zytotoxische T Zellen, die spezifisch das TRP-2 Differenzierungsantigen erkennen, zerstoert werden. Im Rahmen der vorliegenden Arbeit sollte daher eine TRP-2 DNA-Vakzine hergestellt und die Aktivierung TRP-2-spezifischer T-Zellen in der C57BL/6 Maus nach DNA Immunisierung evaluiert werden. …
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The Overexpression of a Feedback -Insensitive Anthranilate Synthase in Arabidopsis and Tobacco
… synthase (AS) is the controlling enzyme of the Trp biosynthetic pathway. The activity of AS is feedback inhibited by Trp and its analogs such as 5-methyl Trp (5-MT). Trp analogs are toxic to cells because they cause false feedback inhibition of AS and hinder the normal production of Trp. A …
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Evolution of the structure and function of vertebrate brain gonadotropin-releasing hormone
… generated against mammalian GnRH, Gln⁸-GnRH and Trp⁷,Leu⁸-GnRH and assessing luteinizing hormone (LH)-releasing activity of fractions in a chicken dispersed anterior pituitary cell bioassay. Five GnRH molecular forms have thusfar been structurally characterized in vertebrate brain. In mammals a …
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Characterization of effect of tryptophan ontrp repressor subunit association using fluorescence spectroscopy
trp repressor is an allosteric protein which regulates the expression of the trp operon in E. coli. Binding of tryptophan to trp repressor causes it to bind with high affinity to trp operator DNA. The active form of the protein is accepted to be dimeric. Preliminary results from our lab and others …
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