Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"TPH2"”.
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
… of the second isoform of tryptophan hydroxylase (TPH2) has brought renewed interest to this field as the majority of this second isoform is centrally expressed and it contains an additional 41 amino acids at the N-terminus compared to TPH1, the peripheral enzyme. To increase the understanding of …
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Cocaine Dependence: The Role of Serotonin Genes In
… 2C and tryptophan hydroxylase 1 and 2 (TPH1 and TPH2). We predicted that attentional bias and impulsivity would be higher in cocaine dependent individuals who had lower serotonin function. In the current study, we found a significant association between TPH2 genotype and attentional bias for the …
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The effect of genotype on attention bias in rhesus macaques, Macaca mulatta, as a welfare indicator.
… and long allele), tryptophan hydroxylase 2 (TPH2; short and long allele), monoamine oxidase A (MAOA; 5-, 6- and 7-repeat allele) and mu-opioid receptor (OPRM1; C and G allele). Additionally, sequencing was utilised to identify novel SNPs in the dopamine receptor D4 (DRD4). The 5-HTTLPR …
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The Molecular Evolution of the Serotonin System in Macaques (MACACA): a Detailed Survey of Four Serotonin-Related Genes
… functioning and behavior: HTR1A, HTR1B, TPH2, and SLC6A4. I examine the pattern of genetic variation within and between several species of macaque, and, using an approach based on molecular evolutionary theory, discern which evolutionary force – positive selection, balancing selection, …
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The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
… the functioning of tryptophan hydroxylase 2 (TPH2), the rate limiting enzyme in the biosynthesis of serotonin, on interindividual differences in the startle response was investigated in three different age samples: children, young adults and older adults. There was a sex × TPH2 genotype …
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Autismikirjon häiriöiden prenataaliset riskitekijät ja niiden hypoteettiset vaikutusmekanismit
… kannalta olennaisten geenien (TPH1 ja TPH2) ilmenemiseen. Retinoiinihappo-estradioliteoriassa kolmen endogeenisen kemiallisen aineen (retinoiinihappo [RA], estradioli ja human alpha-fetoprotein [HAFP]) keskinäinen tasapaino vaikuttaa olennaisesti sikiönkehityksen kulkuun: RA vakuttaa …
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Exploring combined effects of arsenic and selenium exposure on larval zebrafish (Danio rerio)
… (Sncgb, otpa, robo2, th1), serotonergic (pet1, tph2), and motor neuron (pax2a) was observed following arsenic exposure. At the same time, co-treatment with As + Se 25 µg/L partially restored nrf2a expression (p < 0.05). These findings highlight the potential for naturally co-occurring Se to …
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Quantitative Genexpressionsanalyse im respiratorischen Netzwerk an Mausmodellen für das Rett-Syndrom
… auf Grin1 (P7), Grin2a (P7), Gabrb1 (P7), Tph2 (P7), Ddc (P40), Slc6a4 (P7), Htr4 (P7) und als Aktivator auf Grin2d (P7), Drd4 (P7), Oprm1 (P40) wirken könnte. Sehr starke Evidenzen weisen daraufhin, dass Htr5b und Foxp2 ebenfalls Zielgene von MeCP2 sind und dass MeCP2 supprimierend auf …
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Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
… and the 5-HT producing enzymes, TPH1 and TPH2 as well as DDC. Cellular localization for 5-HT1A, 5-HT1D and 5-HT2A were observed in both β- and α-cells; while 5-HT2B was only present in β-cells. Agonists targeting these four receptors were able to either inhibit or stimulate insulin …
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Sex Differences and the Role of the Serotonin System in Early Life Stress-Induced Ethanol-Motivated Behaviors in Adulthood
… Chemogenetic activation of DRN 5-HT neurons in Tph2-iCre rats reduced responding for both natural and EtOH reward and elevated punished responding for EtOH, indicating a causal connection between DRN 5-HT signaling and acute responding to rewards and punishment. Collectively, our findings reveal …