Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"TGF-alpha"”.
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… of eicosanoids in the mitogenic actions of TGF$\alpha$ on granulosa cells during follicular development, as well as its involvement in the regulation of urokinase plasminogen activator, an enzyme playing an important role in tissue remodelling. Granulosa cells from the first (F1), fifth, and …
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Network analyses for functional genomic screens in cancer
… and its ligand, transforming growth factor alpha (TGF[alpha]) are clinically relevant to gastric cancer. We use an shRNA screen and Prize Collecting Steiner Forest (PCSF) algorithm to discover the pathway regulating TGF shedding. This pathway identifies common regulators of TGF[alpha] …
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Integrin Alpha Subunit Ratios, Cytoplasmic Domains, and Growth Factor Synergy Regulate Muscle Proliferation, Differentiation, and Signaling
… was addressed by ectopic expression of integrin alpha subunits in primary quail skeletal muscle. Ectopic expression of either the human or $\alpha$5 or the chicken $\alpha$6 subunit produced contrasting phenotypes. The $\alpha$5 transfected myoblasts remain in the proliferative phase and are …
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Growth-factor-induced mitogenesis: Trafficking determinants of the cellular response
… system. The mitogenic responses elicited by EGF, TGF$\alpha$, and an EGF-variant (Y13G) which possess different surface binding affinities and altered intracellular fates, are compared in distinct experimental scenarios, with or without ligand replenishment. Our results show that cellular uptake …
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Altered estrogen receptor and transforming growth factor pathways in models of estrogen-autonomous and of antiestrogen-resistant MCF-7 human breast cancer cells
… pathway and the transforming growth factor (TGF) pathways during this progression. MCF-7 cells maintained long-term in steroid-deprived conditions exhibited a decreased growth reliance on estrogen despite elevated levels of estrogen receptor. Antiestrogen sensitivity was maintained and …
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Charakterisierung der Helicobacter pylori-assoziierten Magenadenokarzinogenese am Tiermodell des Mongolischen Gerbils: Rolle der cag-Pathogenitätsinsel bei der Induktion präkanzeröser Prozesse.
… Beteiligung des EGF-Rezeptors sowie des Liganden TGF-alpha bei der Aktivierung der Gastrinexpression nachgewiesen werden. Das von H. pylori induzierte, aus der Epithelzelle der Magenmukosa sekretierte Chemokin IL-8 bewirkt im Tiermodell eine frühe Infiltration von immunreaktiven Zellen, sowie die …
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Notch Signaling in Human Neuroblastoma Cells
Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, …