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Showing 1 to 20 of 132 for “"TGF beta"”.

  1. TGF-beta signaling at the cellular junctions

    Dudu, VeronicaTechnische Universität Dresden

    … I have studied transforming growth factor-beta (TGF-beta) signal from the secreting to the receiving cells in the developing wing epithelial cells and at the neuromuscular junctions. Cell culture studies have suggested that cells modulate morphogenetic signaling by expressing the receptors …

    qucosa-diss

  2. Involvement of TGF-beta in skin photoaging

    Choi, Won Seon, 1975-Massachusetts Institute of Technology2005

    … this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major hallmark of photoaging. However, the mechanisms by which UV radiation causes solar …

    mit Repository record

  3. TGF-beta und Empfindlichkeit für NO-abhängige Apoptose

    Moosmann, Nicolas

    … apoptotischen Zelltod induzieren. Dabei spielt TGF-beta eine zentrale Rolle. 48-stündige Einwirkung von TGF-beta auf nicht-transformierte NRK-Fibroblasten steigert deren normalerweise niedrige Empfindlichkeit gegenüber NO. 208 F Fibroblasten lassen sich nicht gegenüber der Apoptoseinduktion …

    freiburg-diss Repository record

  4. TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION

    FISICHELLA, VINCENZOUniversità degli studi di Catania2017

    … macular degeneration (AMD) using amyloid-beta (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats …

    catania Repository record

  5. Knochenneubildung durch induktive Implantate der TGF-Beta-Familie : eine tierexperimentelle Studie zum Synergismus von BMP-2-Mutanten und TGF-Beta bei der heterotopen Osteoinduktion

    Janke, Carsten Theodor WilhelmUniversität Würzburg

    … Einfluss des Faktors „Transforming growth factor beta 1“ auf das physiologische Remodelling des Knochens sind durch zahlreiche In-vitro- und In-vivo-Untersuchungen belegt. Die gentechnische Modifikation der N-terminalen Aminosäuresequenz von rekombinantem, im bakteriellen System (E. coli) …

    wurz-thes Repository record

  6. Die Entwicklung der Pankreasfibrose im TGF-beta-1-transgenen Tiermodell

    Ruf, Doris AnneUniversität Ulm

    ulm-diss Repository record

  7. TGF-beta in chronic sinus diseases: from immuneregulation to remodeling

    VAN BRUAENE, NICHOLASGhent University. Faculty of Medicine and Health Sciences2012

    ghent Repository record

  8. TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor

    Wu, MinWake Forest University2011

    TGF-beta activated kinase-1 (TAK1) encoded by the MAP3K7 gene is a serine/threonine protein kinase that functions in the regulation of cell proliferation, apoptosis, differentiation and/or inflammation. Genetic studies have shown that hemizygous deletion of the MAP3K7 gene is frequent (32%) in …

    wfu Repository record

  9. Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis

    Zavala Góngora, RicardoUniversität Würzburg

    … zur Steuerung von Entwicklungsvorgängen ist das TGFβ/BMP-System, das aus strukturell verwandten Zytokinen der TGFβ (transforming growth factor β) bzw. BMP (bone morphogenetic protein)-Familie, oberflächenständigen Rezeptoren der TGFβ-Rezeptorfamilie (Typ I und Typ II) und intrazellulären …

    wurz-thes Repository record

  10. Phosphorylation and activation of transforming growth factor beta (TGF-[beta]) receptor kinases

    Chen, FengMassachusetts Institute of Technology1996

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.

    mit Repository record

  11. Modulation of TGF-beta and extracellular matrix in retionic acid-induced cleft palate

    Degitz, Sigmund Jay, Jr.University of Illinois at Urbana-Champaign2011

    The morphologic findings of altered mesenchymal organization and delayed elevation of the palatal shelves indicate RA-induced changes in palatal shelf extracellular matrix. The patterns of localization of collagen I, III, and IV, fibronectin, tenascin, laminin and hyaluronate were investigated in …

    uiuc Repository record

  12. Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells

    Lutz, MarionUniversität Würzburg

    Transforming growth factor-ß (TGF-ß) is a multifunctional cytokine that is engaged in regulating versatile cellular processes that are pivotal for development and homeostasis of most tissues in multicellular organisms. TGF-ß signal transduction is initially propagated by binding of TGF-ß to …

    wurz-thes Repository record

  13. Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression

    Lee, Jason Dole2009

    … among women. The transforming growth factor-beta (TGF-β) pathway is an important modulator of breast cancer progression, acting in a tumor suppressing fashion in early carcinogenesis but switching in a poorly understood fashion to a promoter of cancer progression in later stages. …

    duke Repository record

  14. Proliferation von Lungenfibroblasten in vitro unter dem Einfluss von ionisierender Strahlung bzw. von TGF-Beta 1

    Moeller, AntjeUniversität Würzburg

    … kommen. Bei diesen Prozessen scheint TGF-b1, welches durch ionisierende Strahlung aktiviert werden kann, eine entscheidende Rolle zu spielen. Wir untersuchten anhand von Rattenlungenfibroblasten Zellzyklusveränderungen nach Bestrahlung, die eventuell TGF-b1 vermittelt sind. Es wurden …

    wurz-thes Repository record

  15. Klonierung und Charakterisierung von Rezeptorkinasen der EGF- und TGF-Beta-Familie des kleinen Fuchsbandwurmes Echinococcus multilocularis

    Kroner, AntjeUniversität Würzburg

    … der EGF Familie, eine Serin- Threoninkinase der TGF- Familie sowie ein intrazellulärer Signaltransduktionsfaktor der Smad- Familie aus dem Fuchsbandwurm Echinococcus multilocularis charakterisiert. Mittels degenerativer PCR und 3´/ 5´-RACE Methoden konnten drei E. multilocularis cDNAs …

    wurz-thes Repository record

  16. Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma

    Abbood, L2021

    … trauma. IL-8 as a pro-inflammatory cytokine and TGF-β as a pleiotropic cytokine with a potent regulatory activity were investigated for their potential as early biomarkers. The availability of such biomarkers will aid in patient stratification, thus enabling prioritisation of such patients for …

    salford Repository record

  17. SYK promotes TGF-beta-induced P-body clearance in breast cancer cells through the enhancement of autophagy

    Hardy, Shana D

    … in breast cancer cells. I discovered that TGF-β, a known driver of EMT, promotes P-body formation in breast cancer cells and that this increase correlates with the induction of EMT. Also, when mRNA-decapping enzyme 1A, DCP1A, is over-expressed, which results in the formation of aberrant …

    purdue-thes Repository record

  18. The Role of Extracellular Matrix Rigidity and Altered microRNA Expression In TGF-beta-Mediated Breast Cancer Progression

    Taylor, Molly AnnCase Western Reserve University School of Graduate Studies2013

    … poorly defined. Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that functions to suppress tumorigenesis in mammary epithelial cells (MECs). Interestingly, mammary tumorigenesis converts TGF-beta from a tumor suppressor to a tumor promoter through molecular …

    ohiolink Repository record

  19. The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study

    이, 현수2015

    … blot analysis 5 G. Incubation with exogenous TGF-ß1 6 H. Statistical analysis 6 RESULTS 7 A. Cell viability assay 7 B. The effect of LLLT on the expression of mRNA of TGF-ß/smad signaling molecules 9 C. The effect of LLLT on the protein expression of TGF-ß/smad signaling …

    ajou Repository record

  20. Requirement of Baboon/dsmad2-Mediated Tgf-Beta/activin Signaling for Post-Mitotic Neuronal Development in the Drosophila Brain

    Zheng, XiaoyanUniversity of Illinois at Urbana-Champaign2015

    … involvement of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. Interestingly, this stage-specific Babo/dSmad2 signaling appears to accelerate maturation and morphogenesis of post-mitotic neurons …

    uiuc Repository record

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