Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 316 for “"TCR"”.
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A Single Cell Approach to TCR Signal Strength
… release of cytolytic granules. T cell receptor (TCR) recognition of foreign peptides presented by Class I MHC molecules stimulates naïve CD8+ T cell differentiation to effector cells and triggers the cytolytic activity of effector CTLs. Signal transduction downstream of the TCR is a highly …
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How TCR signal strength controls CTL polarisation for target killing
… of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide chain loaded into a major-histocompatability complex, triggering signalling, inducing the CTL to attach and kill target cells. Key stages in this attack are the initial conjugation followed by polarisation and …
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… cells. The studies presented here establish that TCR and cytokines have distinct and complementary roles in promoting inhibitory receptor expression. In vitro, IL-27, type I IFN, and IFN-g induced expression of PD-L1 and Sca-1 on naïve murine CD4+ and CD8+ T cells in the absence of TCR …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… However, it remains unknown how T cell receptor (TCR) engagement impacts the self-renewal capacity of Tpex in settings of continued antigen exposure. Given that many cancer cells lack antigens capable of effectively engaging with TCRs, it is important to understand whether and how TCR engagement …
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Σχεδιασμός και σύνθεση πεπτιδομιμητικών μορίων με βάση το τριμοριακό σύμπλοκο MHC-πεπτίδιο-TCR
… της μυελίνης και του Υποδοχέα των Τ-κυττάρων (TCR). Στην παρούσα διατριβή, πραγματοποιήθηκε λεπτομερής χαρτογράφηση των αλληλεπιδράσεων που λαμβάνουν χώρα κατά τη δημιουργία του τριμοριακού συμπλόκου HLA- πεπτιδίου αντιγόνο-TCR, η οποία θα μπορούσε να δώσει τα απαραίτητα χαρακτηριστικά για τον …
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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… expression of antigen-specific T cell receptor (TCR) genes is a promising approach for immunotherapy against infectious diseases and cancers. A key to the efficient application of this approach is the rapid and specific isolation and cloning of TCRs. Current methods are often labor-intensive, …
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Experimental Characterization of Heat Transfer and Fluid Flow in TCR Fuel Elements under Varying Operational Conditions
… <p>The Transformational Challenge Reactor (TCR) marks a significant leap forward in nuclear reactor innovation, focusing on modular construction, high efficiency, and improved safety. This research explores the coupled behavior of heat transfer and fluid flow within the TCR's 3D-printed …
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The Role of TCR Specificity in the Regulation of the Immune Response to Self and Commensal Antigens
ABSTRACT OF THE DISSERTATION The Role of TCR Specificity in the Regulation of the Immune Response to Self and Commensal Antigens by Stephanie K. Lathrop Doctor of Philosophy in Biology and Biomedical Sciences: Immunology) Washington University in St. Louis, 2010 Dr. Chyi-Song Hsieh, Chairperson The …
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Experimental Investigation And Performance Analysis Of The Transformational Challenge Reactor (Tcr) System Under Various Temperature And Pressure Conditions
<p>The Transformational Challenge Reactor (TCR) represents a significant advancement in nuclear reactor technology, taking into consideration modularity, efficiency, and safety. This study explores the coupling between thermal behavior and the coolant gas flow behavior of the TCR’s 3D-printed …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… signal is mediated via the T cell receptor (TCR) following its interaction with the peptide presented on class-I major histocompability complex (MHC-I) molecules. The second signal is delivered via the co-stimulatory receptors upon recognition of their ligands on antigen presenting cells. …
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Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
… they rarely express a T cell receptor (TCR), but are often positive for CD4 and produce cytotoxic proteins such as perforin and Granzyme B, but in the absence of CD8, questioning the origin and pathogenesis of this malignancy. Expression of NPM-ALK in mice from the T-cell specific CD4 …
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Study of the intracellular trafficking of the pre-T-cell receptor and its role in T-cell lineage commitment
… capacity of the T-cell antigen receptor (TCR) is tested. One such checkpoint is the generation of the clonotypic chains of the two TCR variants (αβ-TCR or γδ-TCR) by V(D)J recombination. Importantly, the TCRα chain is rearranged only after correct TCRβ expression, which requires the latter …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… specific way through their T-cell Receptors (TCR). As the genetic sequence encoding for the TCR is the result of somatic recombination, the TCR sequence varies from T-cell to T-cell, making it a functional barcode. The collection of TCRs present in an individual is known as a TCR repertoire, …
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Transcription Coupled DNA Repair in Saccharomyces Cerevisiae: the Interplay of Facilitators and Repressors
… chemical adducts. Transcription coupled repair (TCR) is a subpathway of NER dedicated to rapid removal of lesions in the transcribed strand of actively transcribed genes. The TCR mechanism in bacteria has been relatively well elucidated. However, TCR in eukaryotic cells appears to be extremely …
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
… (pMHC) molecules through their T Cell Receptor (TCR). The recognition of antigenic pMHC by the TCR is an extremely sensitive and specific process, discriminating as few as a single antigenic pMHC from the self majority while remaining tolerant to uninfected cells. This unique sensitivity and …
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IDENTIFICATION OF CDC7 AS A NEW REGULATOR OF T CELL ACTIVATION
… was designed to identify novel mediators of TCR signalling. A library of kinase inhibitors was screened for their effects on suppressing activation in several T cell populations. The screening assay was able to identify inhibitors of canonical kinases of TCR signalling and kinases that were …
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Engineering the T Cell Receptor to Protect Host Cells in Superantigen-Induced Septic Shock
… populations by crosslinking a T cell receptor (TCR) with a class II major histocompatability complex (pMHC) product on the host cell surface, thus circumventing the normal recognition of intracellularly-processed antigens. Because SAgs can bind to many different TCRs, SAg engagement of T cells …
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Structure, Function and Engineering of Peptide -Mhc Binding Receptors
… peptide-MHC ligand was explored using various TCR mutants engineered by yeast display. Previous work in the lab showed that mutations in the CDR3 regions of the TCR could generate higher-affinity, peptide-specific TCR variants. In contrast, other CDRs (CDR1, and especially CDR2) of the TCR are …
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High-throughput tools for decoding T cell receptor specificity
… antigens through their T cell receptors (TCRs). These receptors bind to peptides presented by major histocompatibility complex (pMHC) proteins, driving immune responses in cancer, infection, and autoimmunity. Understanding how TCRs recognize antigens is crucial for developing cancer …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative effects, …
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