Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 266 for “"TAT"”.
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Interactions between the TatBC complex and Tat signal peptides during protein transport by the bacterial Tat pathway
The Tat and Sec pathways operate in parallel to translocate proteins across the prokaryotic cytoplasmic membrane and the thylakoid membrane of plant chloroplasts. Unlike the Sec pathway, which translocates unfolded proteins, substrates of the Tat system are transported in a folded state. In …
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MOLECULAR MECHANISM OF HIV-1 TAT INDUCED NEURONAL DYSFUNCTION
… genes. In here, we examined the impact of HIV-1 Tat on CREB-BDNF pathway and whether Tat is using this pathway to cause neuronal deregulation.
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Tat signal peptide recognition during protein maturation and export
… has an N-terminal signal peptide harbouring a Tat (twin-arginine translocation) motif, which follows closely the consensus S/T-R-R-x-F-L-K. As with other proteins transported via the Tat pathway, NapA needs to be fully folded, and cofactor insertion needs to be completed, prior to export. This …
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Silent leges inter arma. Von der Tat bis zur Verurteilung
… zählen der historische Kontext des Falls, der Tatbestand des Mordes und der Ablauf des damaligen Gerichtsverfahrens. Darüber hinaus wird das römische Recht mit dem heutzutage in Deutschland geltenden Strafrecht verglichen. Und zu guter Letzt wird hier die Glaubwürdigkeit verschiedener …
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Characterization of anti-DNA antibody with Tat peptide sequence in CDR
"Tat 펩티드가 삽입된 항-DNA 항체 구조의 생화학적 특성 항-DNA 항체인 3D8 단일 가닥 가변부위 (single chain variable fragment: scFv)는 핵산결합능 및 가수분해활성이 있으며, 3D8 VL 단독부위만으로도 핵산 결합능 및 가수분해능을 발휘한다. 또한 3D8 scFv는 세포막 침투능이 있어서, 세포막을 투과한 후, 세포질에 위치하게 되고, 결국은 세포사멸을 유도한다고 알려져 있다. 본 연구에서는 3D8 scFv의 핵산가수분해 활성은 그대로 유지하면서, 세포막 투과 후 핵으로 이동할 수 있는 …
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Der Proteintransport in Rhodobacter capsulatus und Escherichia coli über das Tat-Transportsystem
… Zustand werden sie posttranslational über den Tat-Weg (twin arginine translocation) in das Periplasma transloziert. Charakteristisch für die Tat-Substrate ist das Doppelarginin-haltige S-R-R-x-F-L-K-Konsensusmotiv in der Signalsequenz. Das Tat-Translokon wird in E. coli von den Membranproteinen …
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HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
… proteins, gp120 (a viral envelope protein) and tat (a protein that upregulates transcription of viral genes). We have studied the effects of gp120 and tat on signaling and production of inflammatory cytokines by Human Pulmonary Artery Endothelial Cells (HPAEC). HPAEC were stimulated at varying …
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Probing the role of Tat proofreading chaperones in the assembly of molybdoenzymes
<br/>The twin-arginine (Tat) system is a specialised translocation machine found in prokaryotes and chloroplasts which serves to export fully folded proteins across the cytoplasmic membrane. Proteins are specifically targeted to this system by N-terminal signal peptides which bear a conserved …
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Untersuchungen zur Rolle des HIV-1-Tat-Proteins in der AIDS-assoziierten Vaskulopathie
… wird gezeigt, dass das regulatorische HIV-1-Tat-Protein und das inflammatorische Zytokin TNF-a synergistisch die Adhäsion der promonozytären Zelllinie U937 und von PBMZ an humane mikrovaskuläre Endothelzellen (HMVEZ) erhöht. Die adhäsionsfördernde Wirkung wurde selektiv bei HIV-1-Tat …
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Recombinant Expression, Purification, and Characterization of an HIV-1 Tat-Human Cyclin T1 Chimera
… requires the interaction of the viral protein Tat with the trans-activation response (TAR) stem-loop of the long-terminal repeat (LTR) portion of nascent viral RNA. The production of viable transcripts is enhanced dramatically by the interaction of HIV-1 Tat with the host protein human Cyclin …
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Evolution psychodynamique à moyen terme du processus vocationnel chez le grand adolescent. Le TAT
… thirty 18years aged adolescents with help of the TAT. These subjects were again tested in a second time, 4 years later. What evolution between 18 and 22 years?
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
… The long-term depression (LTD)-blocking peptide Tat-GluR2 was utilized to investigate whether the expression of cannabinoid-induced LTD (CB-LTD) is required for the cannabinoid impairment of acquisition and consolidation of contextual fear memory. HU210 reduced freezing throughout the test phase …
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Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
… Zellen innerhalb weniger Wochen nach Transplantation in den (apoptotischen) Zelltod mündet, wurden im Rahmen der vorliegenden Arbeit kultivierte NPC in vitro mit dem membranpermeablen und anti-apoptotischen Fusionsprotein TAT-Bcl-xL transduziert. Ziel dieser Dissertationsarbeit war die …
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CANNABINOID MODULATION OF HIV-1 TAT-STIMULATED ADHESION OF MACROPHAGE-LIKE CELLS TO THE EXTRACELLULAR MATRIX
… factors such as the regulatory protein Tat which acts as a chemoattractant for monocytes while also promoting the adhesion of leukocytes to the extracellular matrix (ECM). We have shown that one of the major features of the Tat protein is that it promotes cytoskeletal rearrangement …
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Role of Sub-Cellular Localization and Cellular Factors In Regulation of HIV-1 Tat Protein Stability
<p>Human Immunodeficiency Virus (HIV) -1 Tat protein plays an indispensable role in viral gene transcription. Tat is reported to produce a favorable environment for viral replication by modulating a variety of cellular processes. A vast amount of literature is available on the function and effects …
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