Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1548 for “"T cells"”.
-
Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… is believed that myelin sheath-targeting CD4 T-cells are important mediators of this disease. While it is known that CD8 T-cells are present, oligoclonally expanded and are the predominant T-cell population in the MS CNS lesion, their antigen specificity and function remains to be elucidated. …
-
The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection
… a complex process by diverse populations of cells, that can be harnessed for tumor immunotherapies and vaccinations. Vaccinia virus (VV) is the most studied member of the poxvirus family and is responsible for the successful elimination of smallpox worldwide. It is unique among well-studied …
-
Phospholipase D Signaling in T Cells
… PLD signaling in regulatory and non-regulatory T cells. Inhibition of TCR induced PLD signal preferentially suppressed the growth of non-regulatory T cells while allowing the proliferation of regulatory T cells in the presence of exogenous IL-2. Based on this observation, we hypothesized that PLD …
-
Cd56-Specific T Cells: Using Genetically Engineered T Cells to Redirect Specificity to A T Cell Expressed Antigen
… for applying CARs to new targets. Using T cells to target a T cell expressed antigen, such as CD56, seems counterintuitive in that the T cells would be susceptible to self-targeting a.k.a. fratricide. However, we expand CD56-specific CAR<sup>+</sup> T cells that co-express the CD56 antigen. …
-
Cell Biology of Foxp3+ Regulatory T Cells
<p>T cells play a central role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising …
-
Signalling reactions of PI3Kgamma in T cells
… The involvement of PI3Ks in the activation of T cells is clearly demonstrated and so far mostly related to the PI3K class IA enzymes (alpha, beta and delta isoforms), but it was found that PI3Kgamma, the single member of class IB PI3K, is also involved in the regulation of activation-induced …
-
Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… part, attributed to an increase in regulatory T cells associated with ATR treatment. An increase in regulatory T cells has never been described in association with ATR exposure and could help to explain ATR-mediated immune dysfunction.
-
Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… part, attributed to an increase in regulatory T cells associated with ATR treatment. An increase in regulatory T cells has never been described in association with ATR exposure and could help to explain ATR-mediated immune dysfunction.
-
The role of the class III phosphoinositide 3-kinase VPS34 in regulatory T cells and activated CD8+ T cells
… we explored whether VPS34 is critical for immune cells by generating conditional knockout mice where exon 21 of Pik3c3 (the VPS34 gene) is deleted specifically in regulatory T (Treg) cells or activated CD8+ T cells, respectively. We found that mice with VPS34-deficient Treg cells died within 6 …
-
TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
Antigen presentation to T cells results in their activation through T Cell Receptor (TCR) stimulation, resulting in sustained elevation of cytosolic Ca2+ concentration critical for T cell activation. Sustained Ca2+ signals are important for the activation of Nuclear Factor of Activated T cells …
-
How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… whether tolerance is achieved or not, are CD4+ T cells that can recognize peptides presented on allogeneic (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T cells can …
-
Blimp-1 Regulates Terminal Differentiation of T Cells
… of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral transduction neither dramatically altered secretion of IFN-ã …
-
On Modeling HIV Infection Of Cd4+ T Cells
… model for the interaction of HIV with CD4+ T cells in vivo and define possible parameters and effects of said parameters on the model. We then examine a newer, more simplified model for the interaction of HIV with CD4+ T cells that also considers four populations: uninfected T cells, latently …
-
Ex Vivo Induction of Human Regulatory T Cells
<p>Regulatory T cells (Tregs) are indispensable in the human immune system in the maintenance of self-tolerance and immune homeostasis. The dysregulation of Treg number and/or function plays a critical role in the pathogenesis of cancer, allergy and human autoimmune pathologies such as multiple …
-
Immunomodulatory effect of pneumolysin upon CD4 T cells
… of the pneumococcal toxin, pneumolysin, upon the cells at the heart of the adaptive immune response; the CD4 T cell. I generated purified pneumolysin and a purified pneumolysin mutant called F433 to allow me to examine this potential effect. I found that pneumolysin inhibits in vitro antigen …
-
Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic T cells (CTL). Only T cells isolated from the SF of many RA patients were anergic upon their activation in vitro by stimulation of the T cell receptor and the co-stimulatory receptor CD28 which means that these T …
-
Activation of Helper T Cells by Immune Complexes
Made available in DSpace on 2014-12-14T13:28:19Z (GMT). No. of bitstreams: 1 7913431.pdf: 3767142 bytes, checksum: fb9a97e5c018f0d12b03d1089470af50 (MD5) Previous issue date: 1978
-
CD4+ T cells in the pathogenesis of visceral leishmaniasis
… is dependent on Th1 (IFNγ producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill the intracellular parasites. Despite there being an expansion of CD4+ T cells and an increase in pro-inflammatory molecules in the spleen, humans with active visceral leishmaniasis …
-
Pten Signaling in Regulatory T Cells and Inflammatory Disease
Regulatory T (Treg) cells suppress CD4+ T cell responses during homeostasis and inflammation to prevent autoimmunity and other immune disorders. Although the transcriptional and epigenetic programs impacting Treg cell function have been extensively studied, the signaling and metabolic pathways …
Page 1 of 78