Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"T cell function"”.
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Engineering Antibodies to Control T Cell Function
… a yeast display system was used to show that a T cell receptor ligand (scFv-KJ16) expressed on the surface of yeast was capable of inducing T cell activation. These findings suggest that the yeast display system can be used to discover novel polypeptides that regulate biological functions through …
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The Role of Drak2 in T Cell Function and Autoimmunity
… to limit immune responses and ensure that immune cells target foreign pathogens and not healthy cells of the body. However, some immune cells can escape these checkpoints and attack the body’s healthy cells, leading to tissue destruction and devastating autoimmune disorders. For example, multiple …
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The role of hypoxia in T cell function and immunotherapy
… a high local metabolic demand depletes immune cells of key metabolites including oxygen. Tumour hypoxia is particularly hostile to antitumour cytotoxic CD8+ T cell function by repressing clonal expansion and by eliciting immune checkpoint mechanisms. However, T cells cultured ex vivo at low …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation …
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Cytotoxic T cell function in solid tumors: principles and implications for immunotherapy
Contains fulltext : 145309.pdf (Publisher’s version ) (Open Access)
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The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Function and Metabolism
… (CRF) is a key indicator of the health and function of several bodily systems, but it is unknown how CRF impacts the function of specific immune cells such as cytotoxic CD8+ T cells (Tc). Tc utilize cytokines, such as interferon-γ (IFN-γ), to orchestrate cell mediated responses to viral …
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
… system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process is known as degranulation. In this study, I aimed to establish the CRISPR-Cas9 gene editing technology in primary T cells and to optimise …
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LINE1 MODULATE HUMAN T CELL FUNCTION BY REGULATING PROTEIN SYNTHESIS DURING LIFE SPAN
Le cellule T costituiscono una popolazione che cambia in composizione e funzione durante la vita umana per rispondere efficacemente a vari ambienti e sfide immunitarie. Le cellule T neonatali rappresentano una popolazione distinta di cellule T naïve ad attivazione rapida, prevalentemente composta …
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Defining How Polymorphisms at the Slam Family Locus Affect NK and T Cell Function
… Cs1, are involved in regulating several immune functions such as cellular activation, cytokine secretion, cytotoxicity, and apoptosis. Thus, it is not surprising that dysregulation of this family of receptors is associated with disease states such as systemic lupus erythematosus (SLE) and …
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Study and Therapeutic Interference of T Cell Function in Pressure Overload-induced Heart Failure
… HF were unsuccessful, possibly due to redundant functions of individual cytokines. We attempted to identify and exploit better targets in cardiac inflammation so as to enable an immunotherapy of HF. We linked T cells with HF development in the gold-standard mouse model of HF and in human HF …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
T cells, in particular CD8+ T cells, play a critical role in maintaining immune homeostasis and in eliminating cancerous cells. In recent years it has emerged that cellular metabolism is a central regulator of T cell fate and function. T cell metabolic profiles rapidly fluctuate following T cell …
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Dysregulated B Cells in Relapsing Remitting Multiple Sclerosis and Their Impact on T-Cell Function
… of the central nervous system. The role of B cells in the pathoetiology of MS is substantiated by cell depletion therapies but is not well understood. We hypothesized that B cells from MS patients would secrete more pro-inflammatory cytokines and support T cell responses to self-antigens and …
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Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
The human macrophage cell line U937 was investigated as an in vitro model for human macrophage function in mycobacterial infections. This involved evaluating the ability of differentiated U937 cells to phagocytose Mycobacterium tuberculosis, control intracellular mycobacterial growth, and present …
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Investigation of endogenous and adoptively transferred T cell function in a genetic mouse model of lung adenocarcinoma
… other immunotherapeutic modalities like adoptive cell therapy (ACT). The reasons for these low response rates are not well understood, suggesting an improved understanding of the mechanisms which shape a tumor immune response and promote T cell dysfunction is needed. Toward these ends, we first …
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Role of HAART in reconstituting T-cell function and HIV inhibitory activity in the female genital tract during chronic HIV infection
Includes abstract. Includes bibliographical references.
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… of protein kinase B(PKB)on developmental and functional aspects of T cells, we have generated transgenic mouse lines expressing a constitutively active form of PKB (myrPKB) in early stages of T cell development.Peripheral CD4+ T cells from PKB tg mice are hyperreactive, more efficient in …
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T-cells in COPD to help or harm? A study of T-cells in COPD patients and related aspects of T-cell function in vitro
… forward. Neutrophils, macrophages, T-cells and epithelial cells are considered major players in the inflammation. This thesis focuses on T-cells and the occurrence of T-cell populations in BAL, blood and peripheral lung tissue from COPD patients. In addition, T-cell responses to smoke …
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Induction of Stronger and Long Lasting Vaccine Immunity to Tuberculosis
… for macrophage-mediated priming of CD4 and CD8 T cells respectively through MHC-II and MHC-I pathways. Furthermore, BCG reduces the expression of MHC-II in macrophages of mice after infection, through Toll-like receptor-1/2 (TLR-1/2) mediated signaling. In my first aim, I hypothesized that …
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Biomechanical regulation of T cells: The cytoskeleton at the nexus of force and function
… to this response are T lymphocytes - immune cells that orchestrate the immune response and directly eliminate infected or malignant cells. T cell function is intricately linked to their cytoskeleton, a dynamic network of protein filaments, consisting of actin, microtubules, and intermediate …
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