Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 186 for “"T cell activation"”.
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RNA Dynamics in T Cell Activation
<p>Eukaryotic cells employ multiple posttranscriptional mechanisms to fine tune gene expression programs in response to external signals. Regulation of messenger RNA and microRNA by RNA-binding proteins is critical to the control of this process. Hence, disruptions of RNA regulatory processes …
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Multi-scale models of T cell activation
… underlying the adaptive immune response: the activation of T cells. The specific objectives are: 1) develop efficient and versatile computational frameworks to study multi-scale biological systems in silico; 2) obtain mechanistic insights into how T cells are triggered in vivo. The first …
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Decoding CD4+ T cell activation by multi-modal phenotyping
The activation of CD4+ T cells is strongly implicated in the biology of immune-mediated diseases, yet the molecular and functional mechanisms governing this process remain incompletely understood. With the explosion of profiling and functional genomic methods in the last decade, it is now feasible …
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Rare event simulation for probabilistic models of T-cell activation
… is critical for our survival. One of the major cell types involved in these decisions are the so called T-cells, which are specialized white blood cells with a detection mechanism that is not fully explained until now. There is not a one to one specificity between T-cells and antigens. T-cells …
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Cd4 T Cell Activation And Ox40 Agonist Immunotherapy In Tuberculosis
… (Mtb) infection millions of effector T cells traffic to the lungs, but relatively few find antigen and become activated. We used an antigen receptor reporter mouse (Nur77-GFP) infected with Mtb to distinguish recently activated CD4 T cells from others in the lungs. Recently activated …
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The Function of LAT in T Cell Activation and Autoimmunity
<p>LAT (linker for activation of T cells) is an important transmembrane adaptor protein in TCR-mediated signaling. Upon TCR engagement, LAT associates with multiple proteins which allows for the activation of downstream signaling pathways. The interaction between LAT with phospholipase C …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
The activation of naïve CD4+ T cells by antigen presenting cells is a critical step in the response of the immune system to foreign pathogens and in its acclimation to host tissues. Activation of naïve T cells proceeds through TCR engagement and is further augmented by CD28 costimulation: ensuring …
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Redox Regulation of T cell Activation and Function During Viral Infection
… of reactive oxygen intermediates (ROI) during T cell activation and the importance of their regulation during an immune response. ROI generated in response to receptor stimulation play an important role in mediating cellular responses. We have examined the importance of reversible cysteine …
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The role of the adapter protein TSAd in T cell activation
Introduction: T cells are a part of the adaptive immune system, which is designed to attack pathogens in the body. T cells recognize antigen presented by HLA molecules on the surface of antigen presenting cells (APC) through their T cell receptor. Conjugation formation between T cells and APC turns …
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IDENTIFICATION OF CDC7 AS A NEW REGULATOR OF T CELL ACTIVATION
… was screened for their effects on suppressing activation in several T cell populations. The screening assay was able to identify inhibitors of canonical kinases of TCR signalling and kinases that were not previously characterised in TCR signalling. Through the screening assay, a dual inhibitor …
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The Initial Events of T-Cell Activation in Realistic Model Systems
T cells are part of the cellular component of the adaptive immune system and specifically recognise foreign antigens in the body. They use their membrane-bound T-cell receptor (TCR) to bind small peptide antigens presented within the major histocompatibility complex (pMHC) on the surface of antigen …
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
… an increase in the percentage of CD4⁻ CD8⁻ T cells and a decrease in the percentage of CD4⁺CD8⁺ T cells in the thymus. In addition, such treatment also caused an increase in the percentage of CD4⁺ T cells without significantly affecting the CD8⁺ T cells in the thymus. However, when total …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… the differentiation of germinal center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. Germline BCL6-deficient mouse models limit our ability to study BCL6 …
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The Role of T Cell Receptor: Peptide MHC Affinity in T Cell Activation
… without the need for stabilization, using a T cell display system. T cells bearing the newly isolated TCR bound pepMHC and were activated in the absence of co-receptor. This result demonstrates the feasibility of engineering full-length TCRs on the surface of T cells using a retroviral vector.
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PIP5-Kinase Dependent PIP2 Generation Impairs T Cell Activation by Rigidifying the Actin Cortex
Antigen-specific activation of T cells is initiated by the interaction of T cell receptors (TCRs) with the peptide-loaded MHC complex on antigen presenting cells (APCs). A specialized junction, the immunological synapse (IS), is formed at the T cell-APC interface, where cell surface receptors, …
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Actin Regulatory Dynamics Required for T Cell Activation: A Quantitative and Systems-Level Perspective
T cell activation occurs through interaction with an antigen-presenting cell (APC). Upon activation, signaling ensues with the coordination of dozens of diverse signaling molecules in space and time, a feature of cell signaling we call ‘spatiotemporal patterning’. We performed a systems-scale …
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Applying single-molecule localisation microscopy to achieve virtual optical sectioning and study T-cell activation
… imaging of fluorescently-tagged proteins in live cells with a precision well below that of the diffraction limit. As a single-molecule technique, it has also introduced a new quantitative approach to fluorescence microscopy. In the Part A of this thesis, the design and building of three SMLM …
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Not-so-innocent bystanders? Investigating non-antigen specific CD8+ T cell activation in autoimmune prognosis
… a novel gene expression signature in T cells predictive of clinical outcome in anti-neutrophil cytoplasmic antibodies-associated vasculitis, systemic lupus erythematosus, Crohn’s disease, and ulcerative colitis that is not associated with diagnosis. Two modules (corresponding to sets of …
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Study of T cell activation and migration at the single-cell and single-molecule level
T cells are required by their immunological roles to recirculate in the body and migrate to tissue sites, a journey that exposes them to distorting forces and physical obstacles that hinder their movement. Therefore, they must possess appropriate deformability to accommodate and adapt to these …
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